• norsk
    • English
  • English 
    • norsk
    • English
  • Login
View Item 
  •   Home
  • Fakultet for naturvitenskap (NV)
  • Institutt for fysikk
  • View Item
  •   Home
  • Fakultet for naturvitenskap (NV)
  • Institutt for fysikk
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Degradation of the Chemotherapy Drug 5-Fluorouracil on Surfaces

Kjær, Helene
Master thesis
View/Open
12483_FULLTEXT.pdf (Locked)
12483_COVER.pdf (Locked)
URI
http://hdl.handle.net/11250/2615567
Date
2015
Metadata
Show full item record
Collections
  • Institutt for fysikk [1764]
Abstract
The catalytic effect of different materials concerning degradation of the chemo therapy drug 5-Fluorouracil (5-Fu) has been studied using X-ray Photoelectron Spectroscopy and X-ray Absorption Spectroscopy. The materials in question are commercial grade polycrystalline silver with and without a commercial quality graphene coating, polycrystalline copper (99.9% Cu), platinum (99.9% Pt) and a (111) platinum crystal. The data shows that each material affects the drug differently, but that the result is always that the fluorine atom leaves the 5-Fu molecule at body temperature, possibly indicating the formation of hydrofluoric acid. The conclusion is based on the low fluorine quantity relative to other constituents, and by the change in binding energy of some nitrogen and carbon atoms. The 5-Fu molecule was already altered well below T = -7'C on any surface except the platinum (111) crystal, where the molecule appeared to be intact until T = 0'C.
Publisher
NTNU

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit
 

 

Browse

ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDocument TypesJournalsThis CollectionBy Issue DateAuthorsTitlesSubjectsDocument TypesJournals

My Account

Login

Statistics

View Usage Statistics

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit