dc.contributor.author | Rhudy, Jamie L. | |
dc.contributor.author | Güereca, Yvette M. | |
dc.contributor.author | Kuhn, Bethany L. | |
dc.contributor.author | Palit, Shreela | |
dc.contributor.author | Flaten, Magne Arve | |
dc.date.accessioned | 2019-07-09T05:27:01Z | |
dc.date.available | 2019-07-09T05:27:01Z | |
dc.date.created | 2018-11-05T15:14:29Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Journal of Pain. 2018, 19 (11), 1257-1274. | nb_NO |
dc.identifier.issn | 1526-5900 | |
dc.identifier.uri | http://hdl.handle.net/11250/2603775 | |
dc.description.abstract | Expectations for pain relief and experience/conditioning are psychological factors that contribute to placebo analgesia, yet few studies have studied the physiological mechanisms underlying their effects. This study randomized 133 participants to 4 groups: an expectation only (E-only) group, a conditioning only (C-only) group, an expectation plus conditioning (E+C) group, and a natural history (NH) control group. Painful electric stimulations were delivered before and after an inert cream was applied to the site of stimulation. Pain-related outcomes (pain ratings, nociceptive flexion reflex [NFR], skin conductance response, and heart rate acceleration) were recorded after each stimulation. NFR (a measure of spinal nociception) assessed if placebo analgesia inhibited spinal processing of pain. E+C was the only manipulation that significantly inhibited pain and skin conductance response. Surprisingly, NFR was facilitated in the E+C and E-only groups. No effects were noted for C-only. Mediation analysis suggested 2 descending processes were engaged during E+C that influenced spinal nociception: 1) descending facilitation and 2) descending inhibition that was also responsible for pain reduction. These results suggest that E+C manipulations produce the strongest analgesia and have a complex influence on spinal nociception involving both inhibitory and facilitatory processes. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.title | The Influence of placebo analgesia manipulations on pain report, the nociceptive flexion reflex, and autonomic responses to pain | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1257-1274 | nb_NO |
dc.source.volume | 19 | nb_NO |
dc.source.journal | Journal of Pain | nb_NO |
dc.source.issue | 11 | nb_NO |
dc.identifier.doi | 10.1016/j.jpain.2018.04.012 | |
dc.identifier.cristin | 1627152 | |
dc.description.localcode | This article will not be available due to copyright restrictions (c) 2018 by Elsevier | nb_NO |
cristin.unitcode | 194,67,40,0 | |
cristin.unitname | Institutt for psykologi | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |