• A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium 

      Midttun, Øivind; Ulvik, Arve; Meyer, Klaus; Zahed, Hana; Giles, Graham G.; Manjer, Jonas; Sandsveden, Malte; Langhammer, Arnulf; Sørgjerd, Elin Pettersen; Behndig, Annelie F.; Johansson, Mikael; Freedman, Neal D.; Huang, Wen-Yi; Chen, Chu; Prentice, Ross; Stevens, Victoria L.; Wang, Ying; Le Marchand, Loïc; Weinstein, Stephanie J.; Cai, Qiuyin; Arslan, Alan A.; Chen, Yu; Shu, Xiao-Ou; Zheng, Wei; Yuan, Jian-Min; Koh, Woon-Puay; Visvanathan, Kala; Sesso, Howard D.; Zhang, Xuehong; Gaziano, J. Michael; Fanidi, Anouar; Robbins, Hilary A.; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Peer reviewed; Journal article, 2023)
      Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism increase during inflammation, particularly in response to interferon-gamma (IFN-γ). Neopterin ...
    • Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults 

      Zahed, Hana; Johansson, Mattias; Ueland, Per Magne; Midttun, Øivind; Milne, Roger L.; Giles, Graham G.; Manjer, Jonas; Sandsveden, Malte; Langhammer, Arnulf; Sørgjerd, Elin Pettersen; Grankvist, Kjell; Johansson, Mikael; Freedman, Neal D.; Huang, Wen-Yi; Chen, Chu; Prentice, Ross; Stevens, Victoria L.; Wang, Ying; Le Marchand, Loic; Wilkens, Lynne R.; Weinstein, Stephanie J.; Albanes, Demetrius; Cai, Qiuyin; Blot, William J.; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Shu, Xiao-Ou; Zheng, Wei; Yuan, Jian-Min; Koh, Woon-Puay; Visvanathan, Kala; Sesso, Howard D.; Zhang, Xuehong; Gaziano, J. Michael; Fanidi, Anouar; Muller, David; Brennan, Paul; Guida, Florence; Robbins, Hilary A. (Peer reviewed; Journal article, 2021)
      Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin ...
    • Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts 

      Wang, Ying; Lopera, Esteban; Namba, Shinichi; Kerminen, Sini; Tsuo, Kristin; Läll, Kristi; Kanai, Masahiro; Zhou, Wei; Wu, Kuan-Han; Favé, Marie-Julie; Bhatta, Laxmi; Awadalla, Philip; Brumpton, Ben Michael; Deelen, Patrick; Hveem, Kristian; Faro, Valeria Lo; Mägi, Reedik; Murakami, Yoshinori; Sanna, Serena; Smoller, Jordan W.; Uzunovic, Jasmina; Wolford, Brooke N.; GBMI, .; Willer, Cristen; Gamazon, Eric R.; Cox, Nancy J.; Surakka, Ida; Okada, Yukinori; Martin, Alicia R.; Hirbo, Jibril B. (Peer reviewed; Journal article, 2023)
      Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data ...