Blar i St. Olavs hospital på forfatter "Opdahl, Signe"
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The association of women’s birth size with risk of molecular breast cancer subtypes: a cohort study
Sandvei, Marie Søfteland; Opdahl, Signe; Valla, Marit; Lagiou, Pagona; Vesterfjell, Ellen Veronika; Rise, Tor Vikan; Overrein, Tina Syvertsen; Skjervold, Anette Hansen; Engstrøm, Monica J; Bofin, Anna M.; Vatten, Lars J. (Peer reviewed; Journal article, 2021)Background: Because birth size appears to be positively associated with breast cancer risk, we have studied whether this risk may differ according to molecular breast cancer subtypes. Methods: A cohort of 22,931 women born ... -
Birth size after embryo cryopreservation: larger by all measures?
Landsverk, Eirik; Westvik-Johari, Kjersti; Romundstad, Liv Bente Bergem; Opdahl, Signe (Peer reviewed; Journal article, 2023)STUDY QUESTION Are the changes in birthweight after frozen and fresh embryo transfer associated with corresponding changes in other measures of foetal growth and placental efficiency? SUMMARY ANSWER Although placental ... -
The challenges of selective fertility and carryover effects in within-sibship analyses: the effect of assisted reproductive technology on perinatal mortality as an example
Westvik-Johari, Kjersti; Håberg, Siri Eldevik; Lawlor, Deborah A.; Romundstad, Liv Bente Bergem; Bergh, Christina; Wennerholm, Ulla-Britt; Gissler, Mika; Henningsen, Anna-Karina A.; Tiitinen, Aila; Pinborg, Anja; Opdahl, Signe (Peer reviewed; Journal article, 2023)Background Within-sibship analyses show lower perinatal mortality after assisted reproductive technology (ART) compared with natural conception (NC), a finding that appears biologically unlikely. We investigated whether ... -
DTX3 copy number increase in breast cancer: a study of associations to molecular subtype, proliferation and prognosis
Valla, Marit; Opdahl, Signe; Ytterhus, Borgny; Bofin, Anna M. (Journal article; Peer reviewed, 2021)Purpose The degree of cell proliferation is important for subclassifcation of breast cancers into prognostic and therapeutic groups. DTX3 has been identifed as a driver of proliferation in luminal breast cancer. In this ... -
Long term trends of breast cancer incidence according to proliferation status
Klæstad, Elise; Opdahl, Signe; Raj, Sunil Xavier; Valla, Marit; Bofin, Anna M. (Peer reviewed; Journal article, 2022)Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. ... -
Mortality among young adults born preterm and early term in 4 Nordic nations
Risnes, Kari; Bilsteen, Josephine Funck; Brown, Paul; Pulakka, Anna; Andersen, Anne-Marie Nybo; Opdahl, Signe; Kajantie, Eero Olavi; Sandin, Sven (Peer reviewed; Journal article, 2021)Importance Adverse long-term outcomes in individuals born before full gestation are not confined to individuals born at extreme gestational ages. Little is known regarding mortality patterns among individuals born in the ... -
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes
Klæstad, Elise; Opdahl, Signe; Engstrøm, Monica J; Ytterhus, Borgny; Wik, Elisabeth; Bofin, Anna Mary; Valla, Marit (Peer reviewed; Journal article, 2020)Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 ... -
Risk of Hypertensive Disorders in Pregnancy After Fresh and Frozen Embryo Transfer in Assisted Reproduction: A Population-Based Cohort Study With Within-Sibship Analysis
Petersen, Sindre Hoff; Westvik-Johari, Kjersti; Spangmose, Anne Lærke; Pinborg, Anja Bisgaard; Romundstad, Liv Bente Bergem; Bergh, Christina; Åsvold, Bjørn Olav; Gissler, Mika; Tiitinen, Aila; Wennerholm, Ulla-Britt; Opdahl, Signe (Peer reviewed; Journal article, 2022)Background: Frozen embryo transfer (frozen-ET) is increasingly common because of improved cryopreservation methods and elective freezing of all embryos. Frozen-ET is associated with higher risk of hypertensive disorders ... -
Risk of ovarian cancer in women who give birth after assisted reproductive technology (ART)—a registry-based Nordic cohort study with follow-up from first pregnancy
Sandvei, Marie Søfteland; Pinborg, Anja; Gissler, Mika; Bergh, Christina; Romundstad, Liv Bente Bergem; van Leeuwen, Flora E.; Spaan, Mandy; Tiitinen, Aila; Wennerholm, Ulla-Britt; Henningsen, Anna-Karina; Opdahl, Signe (Peer reviewed; Journal article, 2022)Background There is concern that assisted reproductive technology (ART) may increase ovarian cancer risk, but previous studies are inconclusive. We compared ovarian cancer risk for women who gave birth after ART vs ... -
Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety
Westvik-Johari, Kjersti; Lawlor, Deborah; Romundstad, Liv Bente Bergem; Bergh, Christina; Wennerholm, Ulla-Britt; Gissler, Mika; Henningsen, Anna-Karina Aaris; Håberg, Siri Eldevik; Tiitinen, Aila; Spangmose, Anne Lærke; Pinborg, Anja Bisgaard; Opdahl, Signe (Peer reviewed; Journal article, 2022)Main Outcome Measure(s) Stillbirth (fetal death before and during delivery) and neonatal death (live born with death 0–27 days postpartum). Result(s) Overall, 17,123 (0.37%) singletons were stillborn and 7,685 (0.17%) ... -
Separating parental and treatment contributions to perinatal health after fresh and frozen embryo transfer in assisted reproduction: A cohort study with within-sibship analysis
Westvik-Johari, Kjersti; Romundstad, Liv Bente; Lawlor, Deborah A.; Bergh, Christina; Gissler, Mika; Henningsen, Anna-Karina A.; Håberg, Siri Eldevik; Wennerholm, Ulla-Britt; Tiitinen, Aila; Pinborg, Anja; Opdahl, Signe (Peer reviewed; Journal article, 2021)Background Compared to naturally conceived children, adverse perinatal outcomes are more common among children born after assisted reproductive technology with fresh embryo transfer (fresh-ET) or frozen embryo transfer ... -
Visual and digital assessment of Ki-67 in breast cancer tissue - a comparison of methods
Skjervold, Anette Hansen; Pettersen, Henrik P Sahlin; Valla, Marit; Opdahl, Signe; Bofin, Anna Mary (Peer reviewed; Journal article, 2022)Background In breast cancer (BC) Ki-67 cut-off levels, counting methods and inter- and intraobserver variation are still unresolved. To reduce inter-laboratory differences, it has been proposed that cut-off levels for ...