Blar i St. Olavs hospital på forfatter "Wasner, Kobi"
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Mitochondrial Mechanisms of LRRK2 G2019S Penetrance
Delcambre, Sylvie; Ghelfi, Jenny; Ouzren, Nazzima; Grandmougin, Lea; Delbrouck, Catherine; Seibler, Philip; Wasner, Kobi; Aasly, Jan; Klein, Christine; Trinh, Joanne; Pereira, Sandro L; Grünewald, Anne (Peer reviewed; Journal article, 2020)Several mutations in leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson's disease (PD). The most common substitution, G2019S, interferes with LRRK2 kinase activity, which is regulated by autophosphorylation. ...