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dc.contributor.authorMauland, Karen Klepsland
dc.contributor.authorEng, Øyvin Andre Solberg
dc.contributor.authorYtre-Hauge, Sigmund
dc.contributor.authorTangen, Ingvild Løberg
dc.contributor.authorBerg, Anna
dc.contributor.authorSalvesen, Helga
dc.contributor.authorSalvesen, Øyvind
dc.contributor.authorKrakstad, Camilla
dc.contributor.authorTrovik, Jone
dc.contributor.authorHøivik, Erling Andre
dc.contributor.authorWerner, Henrica Maria Johanna
dc.contributor.authorMellgren, Gunnar
dc.contributor.authorHaldorsen, Ingfrid S.
dc.date.accessioned2018-04-16T08:34:59Z
dc.date.available2018-04-16T08:34:59Z
dc.date.created2018-02-01T08:40:29Z
dc.date.issued2017
dc.identifier.citationOncoTarget. 2017, 8 (62), 105184-105195.nb_NO
dc.identifier.issn1949-2553
dc.identifier.urihttp://hdl.handle.net/11250/2494166
dc.description.abstractDespite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution quantified by computed tomography (CT), in relation to tumor characteristics and outcome. 227 EC patients with preoperative abdominal CT scans were included. Total abdominal fat volume (TAV), subcutaneous abdominal fat volume (SAV) and visceral abdominal fat volume (VAV) were quantified, and visceral fat percentage calculated (VAV%=[VAV/TAV]x100). Waist circumference (WC) and liver density (LD) were measured, and body mass index (BMI) calculated. Data for estrogen, progesterone and androgen receptor (ERα/PR/AR) expression by immunohistochemistry were available for 149 tumors, and global gene expression data for 105 tumors. High BMI, TAV, SAV, VAV and WC, and low LD, were associated with low grade endometrioid tumors and PR and AR positivity (all p≤0.03). High VAV% was associated with high age (p<0.001), aneuploidy (p=0.01) and independently predicted reduced disease-specific survival (HR 1.05, 95% CI 1.00-1.11, p=0.041). Tumors from patients with low VAV% showed enrichment of gene sets related to immune activation and inflammation. In conclusion, high VAV% independently predicts reduced EC survival. Tumors arising in patients with low VAV% show enrichment of immune and inflammation related gene sets, suggesting that the global metabolic setting may be important for tumor immune response.nb_NO
dc.language.isoengnb_NO
dc.publisherImpact Journalsnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleHigh visceral fat percentage is associated with poor outcome in endometrial cancernb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber105184-105195nb_NO
dc.source.volume8nb_NO
dc.source.journalOncoTargetnb_NO
dc.source.issue62nb_NO
dc.identifier.doi10.18632/oncotarget.21917
dc.identifier.cristin1560132
dc.description.localcodePublished by Impact Journals. Licensed under a Creative Commons Attribution 3.0 License.nb_NO
cristin.unitcode194,65,1,0
cristin.unitnameMH fakultetsadministrasjon
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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