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dc.contributor.authorFarup, Per Grønaas
dc.contributor.authorUeland, Thor
dc.contributor.authorRudi, Knut
dc.contributor.authorLydersen, Stian
dc.contributor.authorHestad, Knut
dc.identifier.citationGastroenterology Research and Practice. 2017, 2017 .nb_NO
dc.description.abstractBackground. Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subjects with these disorders. Methods. The FGID, including irritable bowel syndrome (IBS), were classified according to the Rome III criteria, and degree of symptoms was assessed with IBS symptom severity score (IBS-SSS). A range of interleukins (IL), chemokines and growth factors, tryptophan, and kynurenine were analysed in serum and the cerebrospinal fluid (CSF), and short-chain fatty acids (SCFA) were analysed in the faeces. The results are reported as partial correlation (pc) and values. Results. Sixty-six subjects were included. IBS was associated with high levels of tryptophan () and kynurenine () and low level of IL-10 () in the CSF. IBS-SSS was associated with high tumor necrosis factor and low IL-10 in the CSF; and and and , respectively. Propionic minus butyric acid in faeces was negatively associated with IL-10 in the CSF (, ). Conclusions. FGID were associated with a proinflammatory immune activation in the central nervous system and a disturbed tryptophan metabolism that could have been mediated by the faecal microbiotanb_NO
dc.publisherHindawi Publishing Corporationnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleFunctional Bowel Disorders Are Associated with a Central Immune Activationnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalGastroenterology Research and Practicenb_NO
dc.description.localcode© 2017 Per G. Farup et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitnameMH fakultetsadministrasjon
cristin.unitnameRKBU Midt-Norge - Regionalt kunnskapssenter for barn og unge - psykisk helse og barnevern
cristin.unitnameInstitutt for psykologi

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal