Blar i Institutt for bioingeniørfag på forfatter "Lehtinen, Laura"
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Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality
Jukonen, Joonas; Moyano-Galceran, Lidia; Höpfner, Katrin; Pietilä, Elina A.; Lehtinen, Laura; Huhtinen, Kaisa; Gucciardo, Erika; Hynninen, Johanna; Hietanen, Sakari; Grénman, Seija; Ojala, Päivi M.; Carpén, Olli; Lehti, Kaisa (Peer reviewed; Journal article, 2021)Erythropoietin producing hepatocellular (Eph) receptors and their membrane-bound ligands ephrins are variably expressed in epithelial cancers, with context-dependent implications to both tumor-promoting and -suppressive ... -
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance
Pietilä, Elina A.; Gonzalez-Molina, Jordi.; Moyano-Galceran, Lidia; Jamalzadeh, Sanaz; Zhang, Kaiyang; Lehtinen, Laura; Turunen, S Pauliina; Martins, Tomás A; Gultekin, Okan; Lamminen, Tarja; Kaipio, Katja; Joneborg, Ulrika; Hynninen, Johanna; Hietanen, Sakara; Grénman, Seija; Lehtonen, Rainer; Hautaniemi, Sampsa; Carpén, Olli; Carlson, Joseph W.; Lehti, Kaisa (Peer reviewed; Journal article, 2021)Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains elusive. Our results show that platinum-chemotherapy itself ...