Blar i Institutt for bioingeniørfag på forfatter "Carlson, Joseph W."

Viser treff 1-4 av 4

    • Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance 

      Pietilä, Elina A.; Gonzalez-Molina, Jordi.; Moyano-Galceran, Lidia; Jamalzadeh, Sanaz; Zhang, Kaiyang; Lehtinen, Laura; Turunen, S Pauliina; Martins, Tomás A; Gultekin, Okan; Lamminen, Tarja; Kaipio, Katja; Joneborg, Ulrika; Hynninen, Johanna; Hietanen, Sakara; Grénman, Seija; Lehtonen, Rainer; Hautaniemi, Sampsa; Carpén, Olli; Carlson, Joseph W.; Lehti, Kaisa (Peer reviewed; Journal article, 2021)
      Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains elusive. Our results show that platinum-chemotherapy itself ...

    • FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation 

      Gultekin, Okan; Gonzalez-Molina, Jordi; Hardell, Elin; Moyano-Galceran, Lidia; Mitsios, Nicholas; Mulder, Jan; Kokaraki, Georgia; Isaksson, Anders; Sarhan, Dhifaf; Lehti, Kaisa; Carlson, Joseph W. (Peer reviewed; Journal article, 2021)
      Uterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown heterogeneous effects in sarcoma patients. With the goal of ...

    • Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells 

      Gonzalez-Molina, Jordi; Kirchhof, Katharina Miria; Rathod, Bhavik; Moyano-Galceran, Lidia; Calvo-Noriega, Maria; Kokaraki, Georgia; Bjørkøy, Astrid; Ehnman, Monika; Carlson, Joseph W.; Lehti, Kaisa (Journal article; Peer reviewed, 2022)

    • MMP14 expression and collagen remodelling support uterine leiomyosarcoma aggressiveness 

      Gonzalez-Molina, Jordi; Hahn, Paula; Falcão, Raul Maia; Gultekin, Okan; Kokaraki, Georgia; Zanfagnin, Valentina; Braz Petta, Tirzah; Lehti, Kaisa Irene; Carlson, Joseph W. (Peer reviewed; Journal article, 2023)
      Fibrillar collagen deposition, stiffness and downstream signalling support the development of leiomyomas (LMs), common benign mesenchymal tumours of the uterus, and are associated with aggressiveness in multiple carcinomas. ...