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Protein kinase C activation mediates interferon-β-induced neuronal excitability changes in neocortical pyramidal neurons
(Journal article; Peer reviewed, 2014)Background Cytokines are key players in the interactions of the immune and nervous systems. Recently, we showed that such interplay is mediated by type I interferons (IFNs), which elevate the excitability of neocortical ... -
Protein tyrosine phosphatases in multiple myeloma
(Peer reviewed; Journal article, 2020)Many cell signaling pathways are activated or deactivated by protein tyrosine phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. Even ... -
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve
(Journal article; Peer reviewed, 2017)Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for valvulopathy and aortopathy. Here we report a genome-wide association scan of 466 BAV cases and 4,660 age, sex and ... -
Proteinadsorption auf Edelstahl in der Lebensmittelindustrie - Gibt es Wege zu foulingresistenten Oberflächen?
(Journal article; Peer reviewed, 2017)Kann die Oberfläche von Edelstahl dazu beitragen, Fouling zu verhindern? Fouling, d.h. Proteinadsorption, in vielen Fällen gefolgt von Mineralablagerung, hat hohe Kosten u.a. in der Lebensmittelindustrie zur Folge. Ansätze ... -
Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines
(Journal article, 2018)Chromosome-centric Human Proteome Project aims at identifying and characterizing protein products encoded from all human protein-coding genes. As of early 2017, 19,837 protein-coding genes have been annotated in the neXtProt ... -
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia
(Peer reviewed; Journal article, 2017)Plasma cell leukemia is a rare and aggressive plasma cell neoplasm that may either originate de novo (primary PCL) or by leukemic transformation of multiple myeloma (MM) to secondary PCL (sPCL). The prognosis of sPCL is ... -
Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
(Peer reviewed; Journal article, 2022)Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry proteome-wide MR analysis based on ... -
Proteomic analysis of glycated proteins from streptozotocin-induced diabetic rat kidney
(Journal article; Peer reviewed, 2011)Glycation of proteins leading to formation of advanced glycation end products (AGEs) has been considered as one of the important causes of diabetic nephropathy. Therefore, in this study, glycated proteins were detected by ... -
Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells
(Peer reviewed; Journal article, 2023)Photochemical internalization (PCI) is a promising new technology for site-specific drug delivery, developed from photodynamic therapy (PDT). In PCI, light-induced activation of a photosensitizer trapped inside endosomes ... -
The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function
(Peer reviewed; Journal article, 2020)CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of various immune cells. The activation and functional status of CD4+ T cells is important for adequate ... -
Proteomic study of low temperature responses in strawberry cultivars (Fragaria x ananassa Duchesne) that differ in cold tolerance
(Journal article; Peer reviewed, 2012)To gain insight into the molecular basis contributing to overwintering hardiness, a comprehensive proteomic analysis comparing crowns of Fragaria × ananassa (octoploid strawberry) cultivars that differ in freezing tolerance ... -
Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
(Peer reviewed; Journal article, 2021)Background Studies have reported that the combination of some prothrombotic genotypes and overt cancer yields a synergistic effect on VTE risk. Whether individual prothrombotic genotypes or number of risk alleles in a ... -
Protobooth: Gathering and analyzing data on prototyping in early-stage engineering design projects by digitally capturing physical prototypes
(Peer reviewed; Journal article, 2021)Aiming to help researchers capture output from the early stages of engineering design projects, this article presents a new research tool for digitally capturing physical prototypes. The motivation for this work is to ... -
Protocol for a risk assessment of caffeine exposure from multiple sources
(Research report, 2020) -
Protocol for the Cognitive Interventions and Nutritional Supplements (CINS) trial: A randomized controlled multicenter trial of a brief intervention (BI) versus a BI plus cognitive behavioral treatment (CBT) versus nutritional supplements for patients with long-lasting muscle and back pain
(Journal article; Peer reviewed, 2011)Background: Brief intervention programs are clinically beneficial, and cost efficient treatments for low back pain, when offered at 8-12 weeks, compared with treatment as usual. However, about 30% of the patients do not ... -
A protocol for the development and validation of a virtual reality-based clinical test of social cognition
(Peer reviewed; Journal article, 2023)Background Impairments in social cognition are common after traumatic brain injury (TBI) and may have severe negative consequences for patients and their families. Most tests of social cognition have limited ecological ... -
Protocol for the development of a core outcome set for pelvic girdle pain, including methods for measuring the outcomes: the PGP-COS study
(Journal article; Peer reviewed, 2018)Background Pelvic Girdle Pain (PGP) is an important cause of disability and economic cost worldwide. There is a need for effective preventative and management strategies. Emerging studies measure a variety of outcomes ... -
Protocol for the Northern babies longitudinal study: predicting postpartum depression and improving parent–infant interaction with The Newborn Behavioral Observation
(Journal article; Peer reviewed, 2017)Introduction Postpartum depression (PPD) is a prevalent disorder. Studying the factors related to PPD will help to identify families at risk and provide preventive interventions. This can in turn improve the developmental ... -
Protocol for the PreventIT feasibility randomised controlled trial of a lifestyle-integrated exercise intervention in young older adults
(Peer reviewed; Journal article, 2019)Introduction The European population is rapidly ageing. In order to handle substantial future challenges in the healthcare system, we need to shift focus from treatment towards health promotion. The PreventIT project has ...