• norsk
    • English
  • English 
    • norsk
    • English
  • Login
View Item 
  •   Home
  • Fakultet for naturvitenskap (NV)
  • Institutt for fysikk
  • View Item
  •   Home
  • Fakultet for naturvitenskap (NV)
  • Institutt for fysikk
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Influence of oligoguluronates on alginate gelation and on alginate gel properties

Padoł, Anna Maria
Doctoral thesis
View/Open
Anna Maria Padoł_PhD.pdf (Locked)
Fulltext (PDF) available (14.74Mb)
URI
http://hdl.handle.net/11250/2383552
Date
2016
Metadata
Show full item record
Collections
  • Institutt for fysikk [1807]
Abstract
Alginates are very abundant material in nature, mostly known for its gelling ability. Alginate is a family of linear copolymers of β-D-mannuronic acid and α-L-guluronic acid. Due to its biocompatibility, nontoxicity and its mild ionotropic gelation it have paved the way to biomedical and pharmaceutical industries. Where they are used, as immunological isolation barriers between implant and host, functionality for cell entrapment and for controlled drug delivery. Understanding how to control its gelation kinetics and how to yield mechanical properties of alginate hydrogels, is a step to fully exploit the properties of alginates. Oligoguluronates, which are almost pure α-L-guluronic acid (above 90%), opens the possibility of such control without addition of foreign substance. In the thesis high Mw alginate samples mixed with different ratios of oligoguluronates were studied. Gelation was done by in situ technique, where calcium was introduced in an inactive form of CaEGTA, and the gelation speed and the final pH was controlled by d-gluconic acid -lactone. The thesis presents results of measurement done by dynamic light scattering, nanoindentation, small angle X-ray scattering and rheology.
Has parts
Paper 1: Padol, Anna Maria; Maurstad, Gjertrud; Draget, Kurt Ingar; Stokke, Bjørn Torger. Delaying cluster growth of ionotropic induced alginate gelation by oligoguluronate. Carbohydrate Polymers 2015 ;Volum 133. s. 126-134 http://dx.doi.org/10.1016/j.carbpol.2015.07.004 The article in is reprinted with kind permission from Elsevier, sciencedirect.com

Paper 2; A.M.Padoł, K.I.Draget, B.T.Stokke. Effects of added oligoguluronate on mechanical properties of Ca-alginateoligoguluronate hydrogels depend on chain length of the alginate. Is not included due to copyright

Paper 3: Y.Yuguchi, A.Hasegawa, A.M.Padoł, K.I.Draget, B.T.Stokke. Local structure of Ca induced hydrogels of alginate – oligoguluronate blends. Is not included due to copyright
Publisher
NTNU
Series
Doctoral thesis at NTNU;2016:59

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit
 

 

Browse

ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDocument TypesJournalsThis CollectionBy Issue DateAuthorsTitlesSubjectsDocument TypesJournals

My Account

Login

Statistics

View Usage Statistics

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit