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dc.contributor.authorBar, Nadav
dc.contributor.authorRadde, Nicole
dc.date.accessioned2015-09-30T07:18:03Z
dc.date.accessioned2015-10-28T12:12:04Z
dc.date.available2015-09-30T07:18:03Z
dc.date.available2015-10-28T12:12:04Z
dc.date.issued2009
dc.identifier.citationBMC Systems Biology 2009, 3nb_NO
dc.identifier.issn1752-0509
dc.identifier.urihttp://hdl.handle.net/11250/2358319
dc.description.abstractBackground: Feed composition has a large impact on the growth of animals, particularly marine fish. We have developed a quantitative dynamic model that can predict the growth and body composition of marine fish for a given feed composition over a timespan of several months. The model takes into consideration the effects of environmental factors, particularly temperature, on growth, and it incorporates detailed kinetics describing the main metabolic processes (protein, lipid, and central metabolism) known to play major roles in growth and body composition. Results: For validation, we compared our model's predictions with the results of several experimental studies. We showed that the model gives reliable predictions of growth, nutrient utilization (including amino acid retention), and body composition over a timespan of several months, longer than most of the previously developed predictive models. Conclusion: We demonstrate that, despite the difficulties involved, multiscale models in biology can yield reasonable and useful results. The model predictions are reliable over several timescales and in the presence of strong temperature fluctuations, which are crucial factors for modeling marine organism growth. The model provides important improvements over existing models.nb_NO
dc.language.isoengnb_NO
dc.publisherBioMed Centralnb_NO
dc.titleLong-term prediction of fish growth under varying ambient temperature using a multiscale dynamic modelnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-09-30T07:18:03Z
dc.source.volume3nb_NO
dc.source.journalBMC Systems Biologynb_NO
dc.identifier.doi10.1186/1752-0509-3-107
dc.identifier.cristin346301
dc.description.localcode© 2009 Bar and Radde; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO


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