Blar i Fakultet for medisin og helsevitenskap (MH) på tidsskrift "Scientific Reports"

Viser treff 1-20 av 153

    • 5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication 

      Prikrylova, Terezia; Robertson, Julia; Ferrucci, Francesca; Konorska, Dorota Joanna; Aanes, Håvard; Manaf, Adeel; Zhang, Beibei; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Gilljam, Karin Margaretha; Løvkvam-Køster, Caroline; Otterlei, Marit; Dahl, John Arne; Enserink, Jorrit; Klungland, Arne; Robertson, Adam Brian (Journal article; Peer reviewed, 2019)
      In most mammalian cells, DNA replication occurs once, and only once between cell divisions. Replication initiation is a highly regulated process with redundant mechanisms that prevent errant initiation events. In lower ...

    • A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders 

      Schou, Morten Brix; Sæther, Sverre Georg; Drange, Ole Kristian; Brenner, Eiliv; Crespi, Joan Vidal; Eikenes, Live; Mykland, Martin Syvertsen; Pintzka, Carl Wolfgang Schøyen; Håberg, Asta; Sand, Trond; Vaaler, Arne; Kondziella, Daniel (Peer reviewed; Journal article, 2019)
      The clinical significance of anti-neuronal antibodies for psychiatric disorders is controversial. We investigated if a positive anti-neuronal antibody status at admission to acute psychiatric inpatient care was associated ...

    • Abdominal adipose tissue and liver fat imaging in very low birth weight adults born preterm: birth cohort with sibling-controls 

      Kuula, Juho; Lundbom, Jesper; Hakkarainen, Antti; Hovi, Petteri; Hauta-alus, Helena; Kaseva, Nina; Sandboge, Samuel; Björkqvist, Johan; Eriksson, Johan; Pietiläinen, Kirsi H.; Lundbom, Nina; Kajantie, Eero Olavi (Peer reviewed; Journal article, 2022)
      Preterm birth at very low birth weight (VLBW, < 1500 g) is associated with an accumulation of cardiovascular and metabolic risk factors from childhood at least to middle age. Small-scale studies suggest that this could ...

    • Accurate determination of marker location within whole-brain microscopy images 

      Tyson, Adam L.; Vélez-Fort, Mateo; Rousseau, Charly V.; Cossell, Lee; Tsitoura, Chryssanthi; Lenzi, Stephen C.; Obenhaus, Horst-Andreas; Claudi, Federico; Branco, Tiago; Margrie, Troy W. (Journal article; Peer reviewed, 2022)

    • Action Representation in the Mouse Parieto-Frontal Network 

      Tombaz, Tuce; Dunn, Benjamin Adric; Hovde, Karoline; Cubero, Ryan John Abat; Mimica, Bartul; Mamidanna, Pranav; Roudi, Yasser; Whitlock, Jonathan (Peer reviewed; Journal article, 2020)
      The posterior parietal cortex (PPC) and frontal motor areas comprise a cortical network supporting goal-directed behaviour, with functions including sensorimotor transformations and decision making. In primates, this network ...

    • Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls 

      Ness, Henning Ofstad; Ljones, Kristine; Gjelsvik, Randi H; Tjønna, Arnt Erik; Malmo, Vegard; Nilsen, Hans-Olav; Hollekim-Strand, Siri Marte; Dalen, Håvard; Høydal, Morten (Peer reviewed; Journal article, 2022)
      This study evaluated acute cardiac stress after a high-intensity interval training session in patients with type 2 diabetes (T2D) versus healthy controls. High intensity aerobic exercise was performed by 4 × 4-min intervals ...

    • Adaptation, psychometric properties and factor structure of the Spanish Quality in Psychiatric Care-Outpatient Staff (QPC-OPS) instrument 

      Tomás-Jiménez, Manuel; Roldán-Merino, Juan; Sanchez-Balcells, Sara; Schröder, Ingrid Agneta; Lundqvist, Lars-Olov; Puig-Llobet, Montserrat; Moreno-Poyato, Antonio R.; Domínguez del Campo, Marta; Lluch-Canut, Maria Teresa (Peer reviewed; Journal article, 2022)
      Quality of care is a multidimensional concept that should include the perspectives of all parties involved. There are few instruments with adequate psychometric properties for the assessment of the quality of psychiatric ...

    • Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA 

      Dunwell, Thomas L.; Dailey, Simon C.; Ottestad, Anine Larsen; Yu, Jihang; Becker, Philipp W.; Scaife, Sarah; Richman, Susan D.; Wood, Henry M.; Slaney, Hayley; Bottomley, Daniel; Yang, Xiangsheng; Xiao, Hui; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Dai, Hong Yan; Fu, Guoliang (Peer reviewed; Journal article, 2021)
      Liquid biopsy testing utilising Next Generation Sequencing (NGS) is rapidly moving towards clinical adoption for personalised oncology. However, before NGS can fulfil its potential any novel testing approach must identify ...

    • Additive manufacturing of laminar flow cells for single-molecule experiments 

      Ahmadi, Arash; Till, Katharina; Hafting, Yngve; Schuttpelz, Mark; Bjørås, Magnar; Glette, Kyrre; Tørresen, Jim; Rowe, Alexander D.; Dalhus, Bjørn (Journal article; Peer reviewed, 2019)
      A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling ...

    • Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability 

      Booth, James; Špírek, Mário; Lobie, Tekle Airgecho; Skarstad, Kirsten Jane; Krejci, Lumir; Bjørås, Magnar (Peer reviewed; Journal article, 2020)
      Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance development. Here, we show that the intracellular pH of Escherichia coli equilibrates to the ...

    • Arabidopsis myrosinases link the glucosinolate-myrosinase system and the cuticle. 

      Ahuja, Ishita; de Vos, RCH; Rohloff, Jens; Stoopen, G; Halle, Kari Krizak; Ahmad, SJN; Hoang, Linh; Hall, RD; Bones, Atle M. (Journal article; Peer reviewed, 2016)
      Both physical barriers and reactive phytochemicals represent two important components of a plant’s defence system against environmental stress. However, these two defence systems have generally been studied independently. ...

    • Assessing mechanisms of frequency discrimination by comparison of different measures over a wide frequency range 

      Moore, Brian C. J.; Swarnalatha Nagaraj, Vinay (Peer reviewed; Journal article, 2023)
      It has been hypothesized that auditory detection of frequency modulation (FM) for low FM rates depends on the use of both temporal (phase locking) and place cues, depending on the carrier frequency, while detection of FM ...

    • Assessing short-term risk of ischemic stroke in relation to all prescribed medications 

      Janszky, Imre; Vardaxis, Ioannis; Lindqvist, Bo Henry; Horn, Jens; Brumpton, Ben Michael; Strand, Linn Beate; Bakken, Inger Johanne Landsjøåsen; Alsnes, Ingvild Vatten; Romundstad, Pål Richard; Ljung, Rickard; Mukamal, Kenneth J.; Sen, Abhijit (Peer reviewed; Journal article, 2021)
      We examined the short-term risk of stroke associated with drugs prescribed in Norway or Sweden in a comprehensive, hypothesis-free manner using comprehensive nation-wide data. We identified 27,680 and 92,561 cases with a ...

    • The association between body mass index, abdominal fatness, and weight change and the risk of adult asthma: a systematic review and meta-analysis of cohort studies 

      Parasuaraman, Ganeshkumar; Ayyasamy, Lavanya; Aune, Dagfinn; Sen, Abhijit; Nagarajan, Ramya; Rajkumar, Prabhu; Velusamy, Saravanakumar; Manickam, P.; Sivaprakasam, Satish (Peer reviewed; Journal article, 2023)
      Obesity has been associated with increased risk of adult asthma, however, not all studies have found a clear association between overweight and the incidence of asthma, and data on other adiposity measures have been limited. ...

    • Association between depression symptoms and moderately increased levels of the inflammation marker albuminuria is explained by age and comorbidity 

      Romundstad, Solfrid; Hynnekleiv, Torfinn (Peer reviewed; Journal article, 2022)
      The study aimed to examine whether there are associations between depression symptoms and levels of the inflammation marker albuminuria. The 8303 participants in this cross-sectional study were subjects from the second ...

    • Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort 

      Paulsen, Benedikte; Gran, Olga Vikhammer; Severinsen, Marianne T.; Hammerstrøm, Jens; Kristensen, Søren Risom; Cannegieter, Suzanne C.; Skille, Hanne; Tjønneland, Anne; Rosendaal, Frits; Overvad, Kim; Næss, Inger Anne; Hansen, John-Bjarne; Brækkan, Sigrid K. (Peer reviewed; Journal article, 2021)
      Smoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the ...

    • Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy 

      Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Taraldsen, Maria Dalen; Gigante, Bruna; Follestad, Turid; Røsjø, Helge Rørvik; Omland, Torbjørn; Wiseth, Rune; Madssen, Erik; Bye, Anja (Peer reviewed; Journal article, 2023)
      Lipid-rich coronary atherosclerotic plaques often cause myocardial infarction (MI), and circulating biomarkers that reflect lipid content may predict risk of MI. We investigated the association between circulating microRNAs ...

    • Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study 

      Jiang, Lin; Sun, Yi-Qian; Langhammer, Arnulf; Brumpton, Ben Michael; Chen, Yu; Nilsen, Tom Ivar Lund; Leivseth, Linda; Wahl, Sissel Gyrid Freim; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)
      Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported ...

    • Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets 

      Papoutsoglou, Georgios; Karaglani, Makrina; Lagani, Vincenzo; Thomson, Naomi; Røe, Oluf Dimitri; Tsamardinos, Ioannis; Chatzaki, Ekaterini (Peer reviewed; Journal article, 2021)
      COVID-19 outbreak brings intense pressure on healthcare systems, with an urgent demand for effective diagnostic, prognostic and therapeutic procedures. Here, we employed Automated Machine Learning (AutoML) to analyze three ...

    • Automated segmentation of endometrial cancer on MR images using deep learning 

      Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Solteszova, Veronika; Zanna, Antonella; Fasmer, Kristine Eldevik; Krakstad, Camilla; Lundervold, Arvid; Lundervold, Alexander Selvikvåg; Salvesen, Øyvind; Erickson, Bradley J.; Haldorsen, Ingfrid S (Peer reviewed; Journal article, 2021)
      Preoperative MR imaging in endometrial cancer patients provides valuable information on local tumor extent, which routinely guides choice of surgical procedure and adjuvant therapy. Furthermore, whole-volume tumor analyses ...