Blar i Fakultet for medisin og helsevitenskap (MH) på tidsskrift "BMC Cancer"
Viser treff 1-20 av 25
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Angiogenesis and radiological tumor growth in patients with glioblastoma
(Journal article; Peer reviewed, 2018)Background The preoperative growth of human glioblastomas (GBMs) has been shown to vary among patients. In animal studies, angiogenesis has been linked to hypoxia and faster growth of GBM, however, its relation to the ... -
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model
(Journal article; Peer reviewed, 2016)Background: Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, ... -
The association of women’s birth size with risk of molecular breast cancer subtypes: a cohort study
(Peer reviewed; Journal article, 2021)Background: Because birth size appears to be positively associated with breast cancer risk, we have studied whether this risk may differ according to molecular breast cancer subtypes. Methods: A cohort of 22,931 women born ... -
Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer
(Peer reviewed; Journal article, 2023)Background The low level of circulating tumor DNA (ctDNA) in the blood is a well-known challenge for the application of liquid biopsies in early-stage non-small cell lung cancer (NSCLC) management. Studies of metastatic ... -
Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches
(Peer reviewed; Journal article, 2022)Background Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may ... -
Cancer patients' knowledge about their disease and treatment before, during and after treatment: a prospective, longitudinal study
(Journal article; Peer reviewed, 2018)Background Knowledge about disease and treatment is necessary before patients can consent to treatment. One of the few established instruments for evaluating whether sufficient information has been provided, is the EORTC ... -
Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized
(Journal article; Peer reviewed, 2018)Background The relationship between cholesterol and prostate cancer has been extensively studied for decades, where high levels of cellular cholesterol are generally associated with cancer progression and less favorable ... -
Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients
(Journal article; Peer reviewed, 2019)Background The expression of microRNAs (miRNAs) is a promising prognostic and diagnostic tool in hepatocellular carcinoma (HCC). Here we performed small RNA sequencing (sRNA-seq) of tissue, serum and serum exosomes to ... -
Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model
(Journal article; Peer reviewed, 2011)Background Multiple myeloma is an incurable disease requiring the development of effective therapies which can be used clinically. We have elucidated the potential for manipulating the cAMP signaling pathway as a target ... -
Downstaging and survival after Neoadjuvant chemotherapy for bladder cancer in Norway; a population-based study
(Peer reviewed; Journal article, 2022)Background Neoadjuvant chemotherapy (NAC) before radical cystectomy is associated with pathological downstaging (DS) and improved overall survival (OS) in patients with muscle-invasive bladder cancer (MIBC). Population-based ... -
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells
(Journal article; Peer reviewed, 2017)Background: The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a ... -
The impact of age on rectal cancer treatment, complications and survival
(Peer reviewed; Journal article, 2022)Background The number of older patients with rectal cancer is increasing. Treatment outcome discrepancies persist, despite similar treatment guidelines. To offer the oldest patients optimal individually adjusted care, ... -
Long term trends of breast cancer incidence according to proliferation status
(Peer reviewed; Journal article, 2022)Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. ... -
Long-term trends in colorectal cancer: incidence, localization, and presentation
(Peer reviewed; Journal article, 2020)Background The purpose of this study was to assess trends in incidence and presentation of colorectal cancer (CRC) over a period of 37 years in a stable population in Mid-Norway. Secondarily, we wanted to predict the ... -
Longitudinal minimal residual disease assessment in multiple myeloma patients in complete remission - results from the NMSG flow-MRD substudy within the EMN02/HO95 MM trial
(Peer reviewed; Journal article, 2022)Background Multiple myeloma remains an incurable disease with multiple relapses due to residual myeloma cells in the bone marrow of patients after therapy. Presence of small number of cancer cells in the body after cancer ... -
MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
(Journal article; Peer reviewed, 2017)Background The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with ... -
Metabolic characterization of triple negative breast cancer
(Journal article; Peer reviewed, 2014)Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ... -
Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study
(Journal article; Peer reviewed, 2019)Background The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ... -
Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges
(Peer reviewed; Journal article, 2022)Background Few studies have addressed colon cancer surgery outcomes in an unselected cohort of octogenarian patients. The present study aimed to evaluate the relative survival of octogenarian patients after a major resection ... -
Post-treatment work patterns amongst survivors of lymphoma treated with high-dose chemotherapy with autologous stem-cell transplantation
(Peer reviewed; Journal article, 2021)Background This study describes post-treatment work patterns in lymphoma survivors treated with high-dose chemotherapy with autologous stem-cell transplantation (HDT-ASCT). It aims to identify determinants for labour force ...