Blar i Fakultet for medisin og helsevitenskap (MH) på tidsskrift "Nature Communications"
Viser treff 1-20 av 73
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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
(Journal article; Peer reviewed, 2014)Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. ... -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
(Journal article; Peer reviewed, 2016)Large consortia have revealed hundreds of genetic loci associated with anthropometric traits,one trait at a time. We examined whether genetic variants affect body shape as a compositephenotype that is represented by a ... -
Activation of the hypothalamic feeding centre upon visual prey detection
(Journal article; Peer reviewed, 2017)The visual system plays a major role in food/prey recognition in diurnal animals, and food intake is regulated by the hypothalamus. However, whether and how visual information about prey is conveyed to the hypothalamic ... -
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
(Journal article; Peer reviewed, 2011)Mammals have nine different homologues (ALKBH1–9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive. It ... -
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
(Journal article; Peer reviewed, 2019)Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, ... -
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
(Peer reviewed; Journal article, 2020)Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex ... -
Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy
(Journal article; Peer reviewed, 2016)A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug–carrier association after intravenous administration is essential for efficient drug delivery to ... -
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
(Peer reviewed; Journal article, 2020)Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and ... -
Behavior-dependent directional tuning in the human visual-navigation network
(Peer reviewed; Journal article, 2020)The brain derives cognitive maps from sensory experience that guide memory formation and behavior. Despite extensive efforts, it still remains unclear how the underlying population activity unfolds during spatial navigation ... -
Behavioral decomposition reveals rich encoding structure employed across neocortex in rats
(Peer reviewed; Journal article, 2023)The cortical population code is pervaded by activity patterns evoked by movement, but it remains largely unknown how such signals relate to natural behavior or how they might support processing in sensory cortices where ... -
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism
(Peer reviewed; Journal article, 2016)Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically established and maintained by DNA methyltransferases and demethylases. Molecular mechanisms of active DNA demethylation began to surface ... -
The blood proteome of imminent lung cancer diagnosis
(Peer reviewed; Journal article, 2023)Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis in 731 smoking-matched ... -
Breast cancer quantitative proteome and proteogenomic landscape
(Journal article; Peer reviewed, 2019)In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins ... -
The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
(Peer reviewed; Journal article, 2022)Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of the UK Biobank ... -
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
(Peer reviewed; Journal article, 2021)Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ... -
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
(Journal article; Peer reviewed, 2019)The effectiveness of most cancer targeted therapies is short-lived. Tumors often developresistance that might be overcome with drug combinations. However, the number of possiblecombinations is vast, necessitating data-driven ... -
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
(Journal article; Peer reviewed, 2018)The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8+ ... -
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
(Peer reviewed; Journal article, 2020)The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at risk individuals. Here we ... -
Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci
(Peer reviewed; Journal article, 2022)Hernias are characterized by protrusion of an organ or tissue through its surrounding cavity and often require surgical repair. In this study we identify 65,492 cases for five hernia types in the UK Biobank and perform ... -
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals
(Journal article; Peer reviewed, 2021)Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for ...