Browsing Fakultet for medisin og helsevitenskap (MH) by Journals "Cell"
Now showing items 1-5 of 5
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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
(Peer reviewed; Journal article, 2021)Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ... -
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.
(Peer reviewed; Journal article, 2019)Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed ... -
Large-scale two-photon calcium imaging in freely moving mice
(Journal article; Peer reviewed, 2022)We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a microscope weight below 3 g and a highly flexible ... -
Parvalbumin and Somatostatin Interneurons Control Different Space-Coding Networks in the Medial Entorhinal Cortex
(Journal article; Peer reviewed, 2017)The medial entorhinal cortex (MEC) contains several discrete classes of GABAergic interneurons, but their specific contributions to spatial pattern formation in this area remain elusive. We employed a pharmacogenetic ... -
Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing
(Journal article; Peer reviewed, 2021)The N6-methyladenosine (m6A) RNA modification is used widely to alter the fate of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse METTL16) deposits an m6A mark on the 3′ splice site ...