Browsing Fakultet for medisin og helsevitenskap (MH) by Title
Now showing items 9680-9699 of 15693
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N-3 Polyunsaturated Fatty Acids in Health and Disease - Clinical and Molecular Aspects
(Doktoravhandlinger ved NTNU, 1503-8181; 2009:119, Doctoral thesis, 2009) Omega-3 Flerumettede Fettsyrer og Helse – Kliniske og Molekylære Aspekter Omega-3 fettsyrer tilhører gruppen essensielle fettsyrer. Det betyr at vi ikke kan lage dem selv, men at de må tilføres gjennom kosten, ... -
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2
(Journal article; Peer reviewed, 2017)Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ... -
N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients
(Peer reviewed; Journal article, 2022)Despite the growing number of the vaccinated population, COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health burden. Obesity, a metabolic syndrome affecting one-third ... -
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
(Peer reviewed; Journal article, 2020)Background More than 170 post-transcriptional RNA modifications regulate the localization, processing and function of cellular RNAs, and aberrant RNA modifications have been linked to a range of human diseases. The RNA ... -
Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host TMPRSS2
(Peer reviewed; Journal article, 2021)SARS-CoV-2 and its vaccine/immune-escaping variants continue to pose a serious threat to public health due to a paucity of effective, rapidly deployable, and widely available treatments. Here, we address these challenges ... -
Naloksonnesespray – biotilgjengelighet og opptaksmønster i en fase 1-studie
(Journal article; Peer reviewed, 2019)Kameratredning med nalokson i nesespray kan forebygge dødsfall ved opioidoverdoser. For å få best mulig opptak av nalokson i nesen må sprayen gis med et lavt volum med høy medikamentkonsentrasjon. Målet med studien var å ... -
Naloxone for opioid overdose - Pharmacological aspects and dosing in clinical practice
(Doctoral theses at NTNU;2020:236, Doctoral thesis, 2020)Dødsfall fra opioidoverdoser er et stort folkehelseproblem og utdeling av nesespray med motgiften nalokson var foreslått som et tiltak for å redde liv. I 2012 fantes det ingen godkjente nesesprayer på markedet. Istedenfor ... -
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
(Peer reviewed; Journal article, 2020)Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body. ... -
Nanomaterials - Toxic or Therapeutic?
(Master thesis, 2020)Nanomaterialer (NMer), slik som nedbrytningsprodukter av plast og konstruerte medikament leveringspartikler, både slippes ut i miljøet og administreres til mennesker i økende grad. Dette gjør at man stiller spørsmål ved ... -
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles
(Journal article, 2015)The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ... -
Nanoparticle Dynamics in Composite Hydrogels Exposed to Low-Frequency Focused Ultrasound
(Peer reviewed; Journal article, 2023)Pulsed focused ultrasound (FUS) in combination with microbubbles has been shown to improve delivery and penetration of nanoparticles in tumors. To understand the mechanisms behind this treatment, it is important to evaluate ... -
Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach
(Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery
(Journal article, 2015)Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ... -
Nanoparticles, ultrasound and microbubble mediated drug delivery in cancer models
(Doctoral theses at NTNU;2020:97, Doctoral thesis, 2020)Denne avhandlingen omhandler forbedring av kreftbehandling gjennom økt levering av cellegift til kreftvev ved bruk av nanopartikler eller ultralyd kombinert med mikrobobler. Ved å kapsle cellegift inn i nanopartikler kan ... -
Nanoplastics - A Potential Threat To Human Health?
(Master thesis, 2019)Den økende bruken av nanomaterialer i alt fra forbruksprodukter til medisiner har ført til en økende offentlig interesse for hvilke følger eksponeringen kan ha for mennesker og helse. Det å forstå hvilke inflammatoriske ... -
Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells
(Peer reviewed; Journal article, 2022)So far, the human health impacts of nano- and microplastics are poorly understood. Thus, we investigated whether nanoplastics exposure induces inflammatory processes in primary human monocytes and monocyte-derived dendritic ... -
Nanostructured lipid carriers for controlled and triggered drug delivery : synthesis and advanced characterisation
(Master thesis, 2016)The emerging field of nanomedicine allows development of targeted drug delivery systems that improves the efficiency and bioavailability of important therapeutics in the clinic. Translation of engineered nanoparticles for ... -
Narcissism in patients admitted to psychiatric acute wards: its relation to violence, suicidality and other psychopathology
(Journal article; Peer reviewed, 2008)Background: The objective was to examine various aspects of narcissism in patients admitted to acute psychiatric wards and to compare their level of narcissism to that of an age- and gendermatched sample from the general ... -
A Narrative Case Study of How Individuals Construct Meaning Concerning Their Situation Through Their Meetings with Work Counsellors
(Journal article; Peer reviewed, 2023)Unemployed individuals with health problems may need extensive work counselling to return to work. Narrative meaning-making processes provide possibilities for healing and change; however, we do not know enough about how ... -
Narrative exposure therapy for refugees and asylum seekers diagnosed with PTSD – a randomized controlled multicenter treatment study
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:321, Doctoral thesis, 2014)