Browsing Fakultet for medisin og helsevitenskap (MH) by Title
Now showing items 3257-3276 of 15826
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Direct oral anticoagulant concentrations and adherence in stroke patients
(Journal article; Peer reviewed, 2023)No therapeutic ranges linking drug concentrations of apixaban and rivaroxaban to clinical outcomes have been defined. We investigated whether direct oral anticoagulant (DOAC) concentrations among patients admitted to ... -
Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases
(Doktoravhandlinger ved NTNU, 1503-8181; 2008:232, Doctoral thesis, 2008)Direkte reparasjon av alkyleringsskader i DNA og RNA av 2-oksoglutarat- og jernavhengige dioksygenaser All informasjon nødvendig for at en levende organisme skal utvikle seg og fungere er lagret i organismens arvestoff, ... -
Direction- and Angle-Assisted Buttonhole Cannulation of Arteriovenous Fistula in Hemodialysis Patients: A Multicenter Randomized Controlled Trial
(Peer reviewed; Journal article, 2022)Rationale & objective: Arteriovenous fistula cannulation with the buttonhole technique is often preferred by patients but has been associated with an increased infection risk. Guidelines disagree on whether it should be ... -
Disability level and use of long-term care services in Norway: a nationwide registry study
(Peer reviewed; Journal article, 2024) -
Disability pension and symptoms of anxiety and depression: a prospective comparison of farmers and other occupational groups. The HUNT Study, Norway.
(Journal article; Peer reviewed, 2015)Objectives: Agriculture has undergone major changes, and farmers have been found to have a high prevalence of depression symptoms. We investigated the risk of work disability in Norwegian farmers compared with other ... -
Disabled student ambassadors promote inclusion in Norwegian higher education: building competencies and strategies for the future
(Peer reviewed; Journal article, 2023)Disabled students encounter complex barriers to participation and inclusion throughout higher education and face challenges transitioning into employment. This study has engaged eight disabled university students in ... -
Discontinuation rate of sulfasalazine, leflunomide and methotrexate due to adverse events in a real-life setting (NOR-DMARD)
(Peer reviewed; Journal article, 2023)Objectives MTX, LEF and SSZ are conventional synthetic DMARDs (csDMARDs) with a well-established role in the treatment of RA. We aimed to estimate and compare the relative risks for adverse events (AEs) and the ... -
Discovery and development of safe-in-man broad-spectrum antiviral agents
(Peer reviewed; Journal article, 2020)Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral ... -
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals
(Journal article; Peer reviewed, 2021)Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for ... -
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
(Peer reviewed; Journal article, 2022)The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ... -
Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours
(Peer reviewed; Journal article, 2023)Background: Myeloid cells play an essential role in cancer metastasis. The phenotypic diversity of these cells during cancer development has attracted great interest; however, their functional heterogeneity and plasticity ... -
Discovery of Broad-Spectrum Antiviral Agents by Drug Repurposing for Rapid Response to Emergent Viral Pandemics: Building Digital Tools to Advance Translational Research
(Master thesis, 2021)The ongoing COVID-19 pandemic caused by the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in 2019 has highlighted urgency for a more efficient and comprehensive paradigm for antiviral development. ... -
Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling
(Peer reviewed; Journal article, 2015)Discovery of efficient anti-cancer drug combinations is a major challenge, since experimental testing of all possible combinations is clearly impossible. Recent efforts to computationally predict drug combination responses ... -
Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network
(Peer reviewed; Journal article, 2022)The ongoing coronavirus disease 2019 (COVID-19) pandemic has highlighted the need to better understand virus–host interactions. We developed a network-based method that expands the severe acute respiratory syndrome ... -
Discrepancies in drug histories at admission to gastrointestinal surgery, internal medicine and geriatric hospital wards in Central Norway: A cross-sectional study
(Journal article; Peer reviewed, 2017)Objectives To compare discrepancies in drug histories among patients acutely admitted to different hospital wards, classify the discrepancies according to their potential clinical impact and identify appropriate selection ... -
The Discriminant Value of Phase-Dependent Local Dynamic Stability of Daily Life Walking in Older Adult Community-Dwelling Fallers and Nonfallers
(Peer reviewed; Journal article, 2015)The present study compares phase-dependent measures of local dynamic stability of daily life walking with 35 conventional gait features in their ability to discriminate between community-dwelling older fallers and nonfallers. ... -
Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
(Peer reviewed; Journal article, 2020)Purpose: Diffusion-weighted MRI (DW-MRI) is a contrast-free modality that has demonstrated ability to discriminate between predefined benign and malignant breast lesions. However, how well DW-MRI discriminates cancer from ... -
Disease activity during and after pregnancy in women with axial spondyloarthritis: a prospective multicentre study
(Journal article; Peer reviewed, 2018)Objective The aim was to study disease activity in women with axial spondyloarthritis (axSpA) during and after pregnancy. Methods The study included 179 pregnancies in 166 women with axSpA from a Norwegian nationwide ... -
Disease activity during pregnancy and the first year postpartum in women with systemic lupus erythematosus
(Journal article; Peer reviewed, 2017)Objective Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course ... -
Disease activity of juvenile idiopathic arthritis during and after pregnancy: A prospective multicenter study
(Journal article; Peer reviewed, 2018)Objective. To study disease activity in women with juvenile idiopathic arthritis (JIA) during and after pregnancy. There is little previous knowledge about this topic. Methods. Our study included 135 pregnancies in 114 ...