• 53BP1 and BRCA1 control pathway choice for stalled replication restart 

      Xu, Yixi; Ning, Shaokai; Wei, Zheng; Xu, Ran; Xu, Xinlin; Xing, Mengtan; Guo, Rong; Xu, Dongyi (Journal article; Peer reviewed, 2017)
      The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated ...
    • Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells 

      Brian, Ben F; Jolicoeur, Adrienne S; Guerrero, Candace R.; Nunez, Myra G; Sychev, Zoi E; Hegre, Siv Anita; Sætrom, Pål; Habib, Nagy; Drake, Justin M; Schwertfeger, Kathryn L; Freedman, Tanya S. (Journal article; Peer reviewed, 2019)
      The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is ...