Blar i Institutt for materialteknologi på tidsskrift "European Journal of Medicinal Chemistry"
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A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation
(Peer reviewed; Journal article, 2023)The colony-stimulating factor 1 receptor (CSF1R) plays an important role in the regulation of many inflammatory processes, and overexpression of the kinase is implicated in several disease states. Identifying selective, ... -
Identification of fused pyrimidines as interleukin 17 secretion inhibitors
(Journal article; Peer reviewed, 2018)Inhibiting the interleukin 17 pathway is of interest in a number of autoimmune diseases. Herein, 42 fused pyrimidines have been evaluated as interleukin 17 secretion inhibitors using a phenotypic assay with peripheral ... -
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland
(Peer reviewed; Journal article, 2024)The colony-stimulating factor 1 receptor (CSF1R) is an attractive target for inflammation disorders and cancers. Based on a series of pyrrolo[2,3-d]pyrimidine containing two carbo-aromatic rings, we have searched for new ...