Blar i Institutt for kjemi på forfatter "Karlsen, Morten"
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Economical Synthesis of 13C-Labeled Opiates, Cocaine Derivatives and Selected Urinary Metabolites by Derivatization of the Natural Products
Karlsen, Morten; Liu, Huiling; Johansen, Jon Eigill; Hoff, Bård Helge (Journal article; Peer reviewed, 2015)The illegal use of opiates and cocaine is a challenge world-wide, but some derivatives are also valuable pharmaceuticals. Reference samples of the active ingredients and their metabolites are needed both for controlling ... -
Synthesis of 13C-labeled drugs of abuse as internal standards for reducing differences in ion suppressing/alteration effects in LC/MS-MS quantification
Karlsen, Morten (Doktoravhandlinger ved NTNU, 1503-8181; 2014:351, Doctoral thesis, 2014)Stable isotope labelled internal standards (SIL ISs) are often used when legal and illegal drugs are analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Ideally an IS behaves identically as its corresponding ... -
Synthesis of [13C4]-labeled ∆9-tetrahydrocannabinol and 11-nor-9-carboxy-∆9-tetrahydrocannabinol as internal standards for reducing ion supressing/alteration effects in LC/MS-MS quantification
Karlsen, Morten; Liu, Huiling; Johansen, Jon Eigill; Hoff, Bård Helge (Journal article; Peer reviewed, 2014)(−)-Δ9-Tetrahydrocannabinol is the principal psychoactive component of the cannabis plant and also the active ingredient in some prescribed drugs. To detect and control misuse and monitor administration in clinical ...