Blar i Institutt for kjemi på forfatter "Gederaas, Odrun Arna"
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Antitumor effects of selected intermediates in synthesis of unsaturated acyl glucoside. In vitro experiments on cancer cell lines.
Gandawski, Daniel (Master thesis, 2019)I forbindelse med et pågående totalsynteseprosjekt ved NTNU ble biologisk evaluering av mellomprodukter og potensielle fettsyresubstituenter som kreftmiddel utført ved MTT-analyse. I tillegg ble syntesen av to nye ... -
Comparison Between 8-Methoxypsoralen and 5-Aminolevulinic Acid in Killing T Cells of Photopheresis Patients Ex Vivo
Holien, Toril; Gederaas, Odrun Arna; Darvekar, Sagar; Christensen, Eidi; Qian, Peng (Journal article; Peer reviewed, 2018)Background and Objective Extracorporeal photopheresis (ECP), an established modality for cutaneous T‐cell lymphoma (CTCL) and graft‐versus‐host disease, involves ex vivo treatment of isolated leukocytes of a patient with ... -
Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination
Haug, Markus; Brede, Gaute; Håkerud, Monika; Nedberg, Anne Grete; Gederaas, Odrun Arna; Flo, Trude Helen; Edwards, Victoria Tudor; Selbo, Pål Kristian; Høgset, Anders; Halaas, Øyvind (Journal article; Peer reviewed, 2018)Effective priming and activation of tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) is crucial for realizing the potential of therapeutic cancer vaccination. This requires cytosolic antigens that feed into the MHC class ... -
Synthesis and in vitro evaluation of a novel thienopyrimidine with phototoxicity towards rat glioma F98 cells
Gederaas, Odrun Arna; Sørensen, Andreas S.; Lindgren, Mikael; Melø, Thor Bernt; Altin, Dag; Flatby, Ellen M. Samdahl; Høgset, Anders; Hoff, Bård Helge (Peer reviewed; Journal article, 2022)Glioblastoma multiforme is one of the most aggressive cancer forms in humans, and has low recovery rates after surgery, ionizing radiation and chemotherapy. Therefore, there is a high interest in the development of new ... -
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling
Søgaard, Caroline Krogh; Blindheim, Augun; Røst, Lisa Marie; Petrovic, Voin; Nepal, Anala; Bachke, Siri; Liabakk, Nina-Beate; Gederaas, Odrun Arna; Viset, Trond; Arum, Carl-Jørgen; Bruheim, Per; Otterlei, Marit (Journal article; Peer reviewed, 2018)Low response rate and rapid development of resistance against commonly used chemotherapeutic regimes demand new multi-targeting anti-cancer strategies. In this study, we target the stress-related roles of the scaffold ...