Blar i Institutt for kjemi på forfatter "Hansen, Mari Bergan"
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Chemoenzymatic Synthesis of Synthons as Percursors for Enantiopure Clenbuterol and Other β2-Agonists
Blindheim, Fredrik Heen; Hansen, Mari Bergan; Evjen, Sigvart; Zhu, Wei; Jacobsen, Elisabeth Egholm (Journal article; Peer reviewed, 2018)Clenbuterol is a β2-agonist used in the veterinary treatment of asthma in several countries. The drug is listed on the World Antidoping Agency’s prohibited list due to its effect on increased protein synthesis in the body. ... -
Improved understanding of reagents used in the syntheses of enantiopure precursors for (S)-atenolol and (S)-metoprolol
Hansen, Mari Bergan (Master thesis, 2019)Målet med denne masteroppgaven var å undersøke effektene av de ulike reagensene brukt i syntesen av enantiomert rene forløpere, som et bidrag til økt miljøvennlighet i totalsyntesene av (S)-atenolol og (S)-metoprolol. Syntesen ... -
Lipase Catalyzed Synthesis of Enantiopure Precursors and Derivatives for β-Blockers Practolol, Pindolol and Carteolol
Gundersen, Morten Andre; Austli, Guro Buaas; Løvland, Sigrid Sløgedal; Hansen, Mari Bergan; Rødseth, Mari; Jacobsen, Elisabeth Egholm (Peer reviewed; Journal article, 2021)Sustainable methods for producing enantiopure drugs have been developed. Chlorohydrins as building blocks for several β-blockers have been synthesized in high enantiomeric purity by chemo-enzymatic methods. The yield of ...