Browsing Institutt for fysikk by Journals "PLoS ONE"
Now showing items 1-18 of 18
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A high precision method for quantitative measurements of reactive oxygen species in frozen biopsies
(Journal article; Peer reviewed, 2014)Objective: An electron paramagnetic resonance (EPR) technique using the spin probe cyclic hydroxylamine 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (CMH) was introduced as a versatile method for high ... -
A simple way for targeted delivery of an antibiotic: In vitro evaluation of a nanoclay-based composite
(Journal article; Peer reviewed, 2017)The sodium-modified form of fluorohectorite nanoclay (NaFh) is introduced as a potential drug carrier, demonstrating its ability for the controlled release of the broad-spectrum antibiotic Ciprofloxacin through in vitro ... -
Automated calibration and control for polarization resolved second harmonic generation on commercial microscopes
(Journal article; Peer reviewed, 2018)Polarization-resolved second harmonic generation (P-SHG) microscopy has evolved as a promising technique to reveal subresolution information about the structure and orientation of ordered biological macromolecules. To ... -
Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels
(Journal article; Peer reviewed, 2014)A popular approach to make neocartilage in vitro is to immobilize cells with chondrogenic potential in hydrogels. However, functional cartilage cannot be obtained by control of cells only, as function of cartilage is largely ... -
Competition on the Rocks: Community Growth and Tessellation
(Journal article; Peer reviewed, 2010)Crustose lichen communities on rocks exhibit fascinating spatial mosaics resembling political maps of nations or municipalities. Although the establishment and development of biological populations are important themes in ... -
DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation
(Journal article; Peer reviewed, 2014)There is an increasing interest in achieving gene regulation in biotechnological and biomedical applications by using synthetic DNA-binding agents. Most studies have so far focused on synthetic sequence-specific DNA-binding ... -
Energy Landscape of Alginate-Epimerase Interactions Assessed by Optical Tweezers and Atomic Force Microscopy
(Journal article, 2015)Mannuronan C-5 epimerases are a family of enzymes that catalyze epimerization of alginates at the polymer level. This group of enzymes thus enables the tailor-making of various alginate residue sequences to attain various ... -
Feasibility study of the permeability and uptake of mesoporous silica nanoparticles across the blood-brain barrier
(Journal article; Peer reviewed, 2016)Drug delivery into the brain is impeded by the blood-brain-barrier (BBB) that filters out the vast majority of drugs after systemic administration. In this work, we assessed the transport, uptake and cytotoxicity of promising ... -
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers
(Journal article; Peer reviewed, 2017)Carbohydrate–protein interactions govern many crucial processes in biological systems including cell recognition events. We have used the sensitive force probe optical tweezers to quantify the interactions occurring between ... -
Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices
(Journal article; Peer reviewed, 2015)Mineralized biomaterials are promising for use in bone tissue engineering. Culturing osteogenic cells in such materials will potentially generate biological bone grafts that may even further augment bone healing. Here, ... -
Seeing a Mycobacterium-Infected Cell in Nanoscale 3D: Correlative Imaging by Light Microscopy and FIB/SEM Tomography
(Journal article; Peer reviewed, 2015)Mycobacteria pose a threat to the world health today, with pathogenic and opportunistic bacteria causing tuberculosis and non-tuberculous disease in large parts of the population. Much is still unknown about the interplay ... -
The breast cancer-associated glycoforms of MUC1, MUC1-Tn and sialyl-Tn, are expressed in COSMC wild-type cells and bind the C-type lectin MGL
(Journal article, 2015)Aberrant glycosylation occurs in the majority of human cancers and changes in mucin-type O-glycosylation are key events that play a role in the induction of invasion and metastases. These changes generate novel cancer-specific ... -
The Design of Simple Bacterial Microarrays: Development towards Immobilizing Single Living Bacteria on Predefined Micro-Sized Spots on Patterned Surfaces
(Journal article; Peer reviewed, 2015)In this paper we demonstrate a procedure for preparing bacterial arrays that is fast, easy, and applicable in a standard molecular biology laboratory. Microcontact printing is used to deposit chemicals promoting bacterial ... -
The plastoquinone pool of Nannochloropsis oceanica is not completely reduced during bright light pulses
(Journal article; Peer reviewed, 2017)The lipid-producing model alga Nannochloropsis oceanica has a distinct photosynthetic machinery. This organism possesses chlorophyll a as its only chlorophyll species, and has a high ratio of PSI to PSII. This high ratio ... -
Towards a low CO2 emission building material employing bacterial metabolism (1/2): The bacterial system and prototype production
(Journal article; Peer reviewed, 2019)The production of concrete for construction purposes is a major source of anthropogenic CO2 emissions. One promising avenue towards a more sustainable construction industry is to make use of naturally occurring mineral-microbe ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
(Journal article; Peer reviewed, 2018)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ... -
Unique photosynthetic electron transport tuning and excitation distribution in heterokont algae
(Journal article; Peer reviewed, 2019)Heterokont algae are significant contributors to marine primary productivity. These algae have a photosynthetic machinery that shares many common features with that of Viridiplantae (green algae and land plants). Here we ... -
X-ray nanoscopy of a bulk heterojunction
(Journal article; Peer reviewed, 2016)Optimizing the morphology of bulk heterojunctions is known to significantly improve the photovoltaic performance of organic solar cells, but available quantitative imaging techniques are few and have severe limitations. ...