• Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET 

      Henjum, Helge; Dahle, Tordis Johnsen; Mairani, Andrea; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Boer, Camilla Grindeland; Redalen, Kathrine Røe; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian Smeland (Peer reviewed; Journal article, 2023)
      Introduction Tumor hypoxia is associated with poor treatment outcome. Hypoxic regions are more radioresistant than well-oxygenated regions, as quantified by the oxygen enhancement ratio (OER). In optimization of proton ...
    • Hypoxia adapted relative biological effectiveness models for proton therapy: a simulation study 

      Garrido Hernandez, Guillermo; Henjum, Helge; Høiskar, Marte Kåstad; Dahle, Tordis Johnsen; Redalen, Kathrine; Ytre-Hauge, Kristian Smeland (Peer reviewed; Journal article, 2022)
      In proton therapy, a constant relative biological effectiveness (RBE) factor of 1.1 is applied although the RBE has been shown to depend on factors including the Linear Energy Transfer (LET). The biological effectiveness ...