Blar i Institutt for fysikk på forfatter "Redalen, Kathrine"

Viser treff 1-20 av 24

    • The 3rd ESTRO-EFOMP core curriculum for medical physics experts in radiotherapy 

      Garibaldi, Cristina; Essers, Marion; Heijmen, Ben; Bertholet, Jenny; Koutsouveli, Efi; Schwarz, Marco; Bert, Christoph; Bodale, Marin; Casares-Magaz, Oscar; Gerskevitch, Eduard; Koniarova, Irena; Korreman, Stine; Lisbona, Albert; Lopez Medina, Antonio; Maas, Ad; Moeckli, Raphaël; Moore, Margaret; Petrovic, Borislava; Piotrowski, Tomasz; Poli, Esmeralda; Prezado, Yolanda; Reynaert, Nick; Redalen, Kathrine; Stylianou Markidou, Erato; Verellen, Dirk; Jornet, Nuria; Clark, Catharine H. (Peer reviewed; Journal article, 2022)
      Purpose To update the 2011 ESTRO-EFOMP core curriculum (CC) for education and training of medical physics experts (MPE)s working in radiotherapy (RT), in line with recent EU guidelines, and to provide a framework for ...

    • An experimental strategy unveiling exosomal microRNAs 486-5p, 181a-5p and 30d-5p from hypoxic tumour cells as circulating indicators of high-risk rectal cancer 

      Bjørnetrø, Tonje; Redalen, Kathrine; Meltzer, Sebastian; Thusyanthan, Nirujah Sivarajah; Samiappan, Rampradeep; Jegershöld, Caroline; Handeland, Karianne Risberg; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Tumour hypoxia contributes to poor treatment outcome in locally advanced rectal cancer (LARC) and circulating extracellular vesicles (EVs) as potential biomarkers of tumour hypoxia and adverse prognosis have not been fully ...

    • Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer 

      Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Ert; Ree, Anne Hansen; Redalen, Kathrine (Journal article; Peer reviewed, 2019)
      As many as 30% to 40% of locally advanced rectal cancer (LARC) patients experience metastatic progression of the disease. Recognizing the potential of the genetic cargo in tumor-derived exosomes, we hypothesized that plasma ...

    • The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer 

      Meltzer, Sebastian; Kristensen, Annette Torgunrud; Abrahamsson, Hanna Josefine; Solbakken, Arne Mide; Flatmark, Kjersti; Dueland, Svein; Bakke, Kine Mari; Bousquet, Paula; Negård, Anne; Johansen, Christin; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Redalen, Kathrine; Ree, Anne Hansen (Peer reviewed; Journal article, 2021)
      Background In colorectal cancer, the inflamed tumour microenvironment with its angiogenic activities is immune- tolerant and incites progression to liver metastasis. We hypothesised that angiogenic and inflammatory factors ...

    • Comparison of Intravoxel incoherent motion imaging and multiecho dynamic contrast-based MRI in rectal cancer 

      Bakke, Kine Mari; Grøvik, Endre; Meltzer, Sebastian; Negård, Anne; Holmedal, Stein Harald; Mikalsen, Lars Tore G; Lyckander, Lars Gustav; Ree, Anne Hansen; Gjesdal, Kjell-Inge; Redalen, Kathrine; Bjørnerud, Atle (Journal article; Peer reviewed, 2019)
      Background Dynamic contrast‐based MRI and intravoxel incoherent motion imaging (IVIM) MRI are both methods showing promise as diagnostic and prognostic tools in rectal cancer. Both methods aim at measuring perfusion‐related ...

    • Corrigendum to “Circulating exosomal miR-141-3p and miR-375 in metastatic progression of rectal cancer” [Transl Oncol 12 (8) (2019) 1038-1044] 

      Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Erta; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020)

    • Development of an automated production process of [<sup>64</sup>Cu][Cu (ATSM)] for positron emission tomography imaging and theranostic applications 

      Liu, Tengzhi; Redalen, Kathrine; Karlsen, Morten (Peer reviewed; Journal article, 2022)
      Cyclotron-produced copper-64 radioisotope tracers offer the possibility to perform both diagnostic investigation by positron emission tomography (PET) and radiotherapy by a theranostic approach with bifunctional chelators. ...

    • From multisource data to clinical decision aids in radiation oncology: The need for a clinical data science community 

      Kazmierska, Joanna; Hope, Andrew; Spezi, Emiliano; Beddar, Sam; Nailon, William H.; Osong, Biche; Ankolekar, Anshu; Choudhury, Ananya; Dekker, Andre; Redalen, Kathrine; Traverso, Alberto (Journal article; Peer reviewed, 2020)
      Big data are no longer an obstacle; now, by using artificial intelligence (AI), previously undiscovered knowledge can be found in massive data collections. The radiation oncology clinic daily produces a large amount of ...

    • High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer 

      Abrahamsson, Hanna Josefine; Porojnicu, Alina Carmen; Lindstrøm, Jonas Christoffer; Dueland, Svein; Flatmark, Kjersti; Hole, Knut Håkon; Seierstad, Therese; Moan, Johan Emilian; Redalen, Kathrine; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Background:Following curative-intent neoadjuvant therapy in locally advanced rectal cancer, metastaticprogression is still dominant. We investigated if patients’circulating 25-hydroxyvitamin D [25(OH)D] levels wereassociated ...

    • Hypoxia adapted relative biological effectiveness models for proton therapy: a simulation study 

      Garrido Hernandez, Guillermo; Henjum, Helge; Høiskar, Marte Kåstad; Dahle, Tordis Johnsen; Redalen, Kathrine; Ytre-Hauge, Kristian Smeland (Peer reviewed; Journal article, 2022)
      In proton therapy, a constant relative biological effectiveness (RBE) factor of 1.1 is applied although the RBE has been shown to depend on factors including the Linear Energy Transfer (LET). The biological effectiveness ...

    • Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms 

      Liu, Tengzhi; Karlsen, Morten; Karlberg, Anna Maria; Redalen, Kathrine (Peer reviewed; Journal article, 2020)
      Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid tumor environment, associated with malignant progression, radiotherapy resistance, and poor prognosis. One method to detect tumor ...

    • Immunogenic cell death by neoadjuvant oxaliplatin and radiation protects against metastatic failure in high-risk rectal cancer. 

      Bains, Simer Jit; Abrahamsson, Hanna Josefine; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Objective High rates of systemic failure in locally advanced rectal cancer call for a rational use of conventional therapies to foster tumor-defeating immunity. Methods We analyzed the high-mobility group box-1 ...

    • Learning radiation oncology in Europe: Results of the ESTRO multidisciplinary survey 

      Bibault, Jean-Emmanuel; Franco, Pierfrancesco; van Elmpt, Wouter; Thorwarth, Daniela; Schmid, Maximilian P; Rouschop, Kasper M; Spalek, Mateusz; Mullaney, Laura; Redalen, Kathrine; Dubois, Ludwig; Verfaille, Christine; Eriksen, Jesper Grau (Journal article; Peer reviewed, 2018)
      Introduction Radiotherapy education can be very different across Europe, despite the publication of the ESTRO core curricula in 2011. The purpose of the current study is to map the different RO European education systems, ...

    • Markers of mitochondrial metabolism in tumor hypoxia, systemic inflammation, and adverse outcome of rectal cancer 

      Bousquet, Paula; Meltzer, Sebastian; Sønstevold, Linda; Esbensen, Qin Ying; Dueland, Svein; Flatmark, Kjersti; Sitter, Beathe; Bathen, Tone Frost; Seierstad, Therese; Redalen, Kathrine; Eide, Lars; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and ...

    • MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts 

      Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Grøndahl, Aurora Rosvoll; Winter, René; Negård, Anne; Holmedal, Stein Harald; Meltzer, Sebastian; Ree, Anne Hansen; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Futsæther, Cecilia Marie (Peer reviewed; Journal article, 2021)
      Background Tumor delineation is time- and labor-intensive and prone to inter- and intraobserver variations. Magnetic resonance imaging (MRI) provides good soft tissue contrast, and functional MRI captures tissue properties ...

    • Potential of Deep Learning in Quantitative Magnetic Resonance Imaging for Personalized Radiotherapy 

      Gurney-Champion, Oliver J.; Landry, Guillaume; Redalen, Kathrine; Thorwarth, Daniela (Peer reviewed; Journal article, 2022)
      Quantitative magnetic resonance imaging (qMRI) has been shown to provide many potential advantages for personalized adaptive radiotherapy (RT). Deep learning models have proven to increase efficiency, robustness and speed ...

    • Professional quality of life and burnout among medical physicists working in radiation oncology: The role of alexithymia and empathy 

      Di Tella, Marialaura; Tesio, Valentina; Bertholet, Jenny; Gasnier, Anne; Gonzalez del Portillo, Elisabet; Spalek, Mateusz; Bibault, Jean-Emmanuel; Borst, Gerben; Van Elmpt, Wouter; Thorwarth, Daniela; Mullaney, Laura; Redalen, Kathrine; Dubois, Ludwig; Chargari, Cyrus; Perryck, Sophie; Petit, Steven; Lybeer, Myriam; Castelli, Lorys; Franco, Pierfrancesco (Peer reviewed; Journal article, 2020)
      Background and purpose The professional quality of life of radiation oncology professionals can be influenced by different contributing factors, including personality traits. Alexithymia involves deficits in emotion ...

    • Quantitative imaging for radiotherapy purposes 

      Gurney-Champion, Oliver J.; Mahmood, Faisal; van Schie, Marcel; Julian, Robert; George, Ben; Philippens, Marielle E.P.; van der Heide, Uulke A.; Thorwarth, Daniela; Redalen, Kathrine (Peer reviewed; Journal article, 2020)
      Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. ...

    • Semi-automatic tumor segmentation of rectal cancer based on functional magnetic resonance imaging 

      Knuth, Franziska Hanna; Grøndahl, Aurora Rosvoll; Winter, René; Torheim, Turid Katrine Gjerstad; Negård, Anne; Holmedal, Stein Harald; Bakke, Kine Mari; Meltzer, Sebastian; Futsæther, Cecilia Marie; Redalen, Kathrine (Peer reviewed; Journal article, 2022)
      Background and purpose Tumor delineation is required both for radiotherapy planning and quantitative imaging biomarker purposes. It is a manual, time- and labor-intensive process prone to inter- and intraobserver ...

    • Sex differences and tumor blood flow from dynamic susceptibility contrast MRI are associated with treatment response after chemoradiation and long-term survival in rectal cancer 

      Bakke, Kine Mari; Meltzer, Sebastian; Grøvik, Endre; Negård, Anne; Holmedal, Stein Harald; Gjesdal, Kjell-Inge; Bjørnerud, Atle; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020)
      Sex differences, tumor vascularity, and blood flow seen on multiecho dynamic contrast–based MRI scans enabled prediction of treatment response and overall survival in patients with rectal cancer. Background: MRI is the ...