Blar i Institutt for fysikk på forfatter "Davies, Catharina de Lange"
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The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy
Yemane, Petros Tesfamichael; Åslund, Andreas; Sæterbø, Kristin Grendstad; Bjørkøy, Astrid; Snipstad, Sofie; van Wamel, Annemieke; Berg, Sigrid; Mørch, Ýrr Asbjørg; Hansen, Rune; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective ... -
The effect of ultrasound on transport of nanoparticles in an extracellular matrix phantom
Ulvik, Kim Andre (Master thesis, 2021)Kombinasjonen av cellegift med mikroboble og ultralyd har vist potensiale i å forbedre ekstravasasjon av medisiner over blodåreveggen. Derimot er penetrasjon av medisiner gjennom ekstracellulært matriks (ECM) fortsatt en ... -
The impact of tumor associated macrophages in delivery of nanoparticles to tumor cells
Lia, Marianne Elise (Master thesis, 2019)Dagens ineffektive kreftbehandlinger tas hånd om ved innkapsling av cellegift i spesialdesignede nanopartikler som en del av medisinleveringssystemer. Tumorassosierte makrofager (TAMer) kan fungere som en barriere for ... -
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model
Sulheim, Einar; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Borgos, Sven Even F.; Miletic, Hrvoje; Bjerkvig, Rolf; Davies, Catharina de Lange; Åslund, Andreas (Journal article, 2019)Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, ... -
Towards minimizing variations in the comet assay: The electric potential during electrophoresis and implications of circulating the electrophoresis solution
Rolstadaas, Linn (Master thesis, 2016)The comet assay (single cell gel electrophoresis) is a sensitive and versatile technique for measuring DNA damage and repair at the single cell level. Östling and Johanson were the first to introduce the comet assay in ... -
Treatment of Liver Metastases With Focused Ultrasound and Microbubbles in Patients With Colorectal Cancer Receiving Chemotherapy
Haram, Karin Margrete; Hansen, Rune; Bouget, David Nicolas Jean-Marie; Myhre, Ola Finneng; Davies, Catharina de Lange; Hofsli, Eva (Journal article; Peer reviewed, 2023)Objective: Pre-clinical trials have obtained promising results that focused ultrasound (FUS) combined with microbubbles (MBs) increases tumor uptake and the therapeutic effect of drugs. The aims of the study described here ... -
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking
Sofias, Alexandros Marios; Toner, Yohana C.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Soultanidis, Georgios; Elschot, Mattijs; Gonai, Haruki; Grendstad, Kristin; Flobak, Åsmund; Neckmann, Ulrike; Wolowczyk, Camilla; Fisher, Elizabeth L.; Reiner, Thomas; Davies, Catharina de Lange; Bjørkøy, Geir; Teunissen, Abraham J. P.; Ochando, Jordi; Pérez-Medina, Carlos; Mulder, Willem J. M.; Hak, Sjoerd (Journal article; Peer reviewed, 2020)Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles’ (NP) in vivo behavior is complex and the immune system’s role in their application remains elusive. At present, only ... -
Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation
van Wamel, Annemieke; Mühlenpfordt, Melina; Hansen, Rune; Healey, Andrew; Villanueva, Flordeliza S.; Kotopoulis, Spiros; Davies, Catharina de Lange; Chen, Xucai (Peer reviewed; Journal article, 2022)Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ... -
Ultrasound and magnetic resonance imaging for group stratification and treatment monitoring in the transgenic adenocarcinoma of the mouse prostate model
Fagerland, Stein-Martin Tilrum; Hill, Deborah Katherine; van Wamel, Annemieke; Davies, Catharina de Lange; Kim, Jana (Journal article; Peer reviewed, 2020)Background:The transgenic adenocarcinoma of the mouse prostate (TRAMP) is a widelyused genetically engineered spontaneous prostate cancer model. However, both thedegree of malignancy and time of cancer onset vary. While ... -
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
Haram, Karin Margrete; Snipstad, Sofie; Berg, Sigrid; Mjønes, Patricia; Rønne, Elin; Lage Fernandez, Jessica; Mühlenpfordt, Melina; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ... -
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ... -
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ... -
Ultrasound radiation force transport of drugs in tumors
Yemane, Petros Tesfamichael (Master thesis, 2013)Delivery of chemotherapeutic agents administered intravenously tosolid tumors tissue in optimal quantities is one of the challenges in theclinic. However, ultrasound improves the delivery of the chemothera-peutic agents ... -
Ultrasound Stimulated Release of Liposomes
Afadzi, Mercy (Master thesis, 2008)A prerequisite for successful cancer therapy (drug delivery) is that the cytotoxic agents reach all cancer cells and inactivates them and this requires triggerable release of liposomes in order to delivery a high local ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar; Berg, Sigrid; Hansen, Rune; Thorsen, Frits; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange; Åslund, Andreas (Journal article; Peer reviewed, 2018)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ... -
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model
Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ... -
Using atomic force microscopy and second harmonic generation to investigate the effects of ultrasound and microbubbles on the extracellular matrix in 4T1 breast tumors
Bang, Camilla (Master thesis, 2022)For å forbedre leveringen av kreftmedisin til svulster har man sett at bruken av mikrobobler kombinert med ultralyd kan ha en positiv effekt. Denne typen behandling har vist seg å kunne øke distansen legemiddelet beveger ... -
Validating the algorithms AAA and Acuros for calculation of dose from flattening filter free beams in heterogenous tissue - Application to stereotactic radiotherapy of lung tumors
Perander, Kristine (Master thesis, 2015)In radiation therapy of cancer, modeling the dose to the patient is very important. Several computational algorithms are available, where some model dose in heterogeneous tissue better than others. After implementation of ... -
Vascular characterization of tumors growing in the chorioallantoic membrane
Bye, Inger (Master thesis, 2017)The chick chorioallantoic membrane (CAM) model has been widely used to study different biological and medical processes, including angiogenic response, tumor development and drug-delivery. Such studies can be achieved ...