Browsing Institutt for bioteknologi og matvitenskap by Title
Now showing items 61-80 of 1539
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Alginate Beads for the Treatment of Diabetes - Development of Larger Beads with Various Compartments
(Master thesis, 2016)Some diseases lead to the loss of specific types of cells and their associated products, notably type 1 diabetes, an autoimmune disease which causes the loss of the insulin producing β-cells native to the pancreas. Cell ... -
Alginate beads in the bioartificial pancreas – Investigation of properties for transplantation and stem cell differentiation
(Doctoral thesis at NTNU;2015:45, Doctoral thesis, 2015)Cell therapy of diabetes is today limited by two major obstacles preventing widespread application; graft rejection by the recipient’s immune system, and scarcity of cells suitable for transplantation. Microencapsulation ... -
Alginate Biosynthesis Factories in Pseudomonas fluorescens : Localization and Correlation with Alginate Production Level
(Journal article; Peer reviewed, 2016)Pseudomonas fluorescens is able to produce the medically and industrially important exopolysaccharide alginate. The proteins involved in alginate biosynthesis and secretion form a multiprotein complex spanning the inner ... -
Alginate Biosynthesis in Pseudomonas fluorescens SBW25: Investigating Regulatory Aspects Involving Levansucrase and c-di-GMP
(Master thesis, 2023)Alginat er en mye brukt polysakkarid i mat- og legemiddelindustrien. Den består av de kovalent bundne monomerene mannuronsyre (M) og, dens epimer, guluronsyre (G). Sammensetningen av monomerene gjør alginat allsidig, hvilket ... -
Alginate Blocks and Block Polysaccharides: A Review
(Peer reviewed; Journal article, 2023)Alginates consist of distinct blocks with different physical properties. This short review focuses on research carried out in Trondheim related to the early discovery of the block structure, their isolation, their different ... -
Alginate foams as biomaterials
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:241, Doctoral thesis, 2013)Development of biomaterials is crucial for progress in the field of tissue engineering and regenerative medicine. The intention of biomaterials is to interface with biological systems to evaluate, treat, augment or replace ... -
Alginate gels cross-linked with mixtures of calcium and chitosan oligomers: Effect on swelling properties and leakage from the gel
(Master thesis, 2016)A new alginate gelling system was recently reported where chitosan oligomers were used to cross-link alginate (poly-M) (Khong et al., 2013). These results have been followed up by determining the gel strength and syneresis ... -
Alginate gels crosslinked with chitosan oligomers - a systematic investigation into alginate block structure and chitosan oligomer interaction
(Peer reviewed; Journal article, 2021)Three alginates with fundamentally different block structures, poly-M, poly-G, and poly-MG, have been investigated upon ionic crosslinking with chitosan oligosaccharides (CHOS), using circular dichroism (CD), rheology, and ... -
Alginate gels with a combination of calcium and chitosan oligomer mixtures as crosslinkers
(Journal article, 2017)Alginates are polysaccharides that are widely used in relation to their ability to form gels. Recently we reported that alginates may also form gels with chitosan oligomers as crosslinkers (Khong, Aarstad, Skjåk-Bræk, ... -
Alginate hydrogels functionalized with β-cyclodextrin as a local paclitaxel delivery system
(Journal article, 2021)Modification of drug delivery materials with beta-cyclodextrins (β-CyD) is known to increase solubility of poorly water-soluble drugs, protect drugs from degradation and sustain release. In this study, we developed a ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
(Journal article; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood ... -
Alginate microcapsules for cell therapy : a study of functional properties of capsules made of native and enzymatically tailored alginates
(Doktoravhandlinger ved NTNU, 1503-8181; 2002:30, Doctoral thesis, 2002)Alginate-poly-L-lysine(PLL)-alginate capsules are the far most studied system for encapsulation of living cells. Immobilisation in ionically cross-linked alginate provides a simple and safe encapsulation procedure at ... -
Alginate Microcapsules for Cell Therapy: Effect of capsule composition on complement activation, cytokine secretion, and protein adsorption in a whole blood model
(Master thesis, 2012)Encapsulation of pancreatic islets in alginate microbeads and microcapsules show great promise for the treatment of Type 1 diabetes mellitus. Significant progress has been made in developing a biocompatible capsule that ... -
Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia
(Journal article; Peer reviewed, 2013)Islet transplantation in diabetes is hampered by the need of life-long immunosuppression. Encapsulation provides partial immunoprotection but could possibly limit oxygen supply, a factor that may enhance hypoxia-induced ... -
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
(Journal article; Peer reviewed, 2016)The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere ... -
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery
(Peer reviewed; Journal article, 2022)Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid ... -
Alginate modification with the coupling of primary amines relevant for nerve regeneration
(Master thesis, 2014)Alginate is a polysaccharide produced by brown seaweed and some bacteria which is highly demanded in biomedical researches. It can form a gel in presence of divalent cations which has many applications in cell based therapy. ... -
Alginate sequencing: Block distribution in alginates and its impact on macroscopic properties
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:26, Doctoral thesis, 2013) -
Alginate-b-dextran block-copolymers: preparation and solution properties
(Master thesis, 2021)Alginat produseres i rød- og brunalger og utgjør 40% av algenes tørrvekt. Biopolymeren finnes i algenes intracellulære rom hvor det fungerer som et strukturelement, tilnærmet cellulose i landplanter. Rød- og brunalger ... -
Alginate-modifying enzymes: Biological roles and biotechnological uses
(Journal article; Peer reviewed, 2015)Alginate denotes a group of industrially important 1-4-linked biopolymers composed of the C-5-epimers β-D-mannuronic acid (M) and α-L-guluronic acid (G). The polysaccharide is manufactured from brown algae where it constitutes ...