Now showing items 21-40 of 554
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Addressing uncertainty in genome-scale metabolic model reconstruction and analysis
(Peer reviewed; Journal article, 2021)The reconstruction and analysis of genome-scale metabolic models constitutes a powerful systems biology approach, with applications ranging from basic understanding of genotype-phenotype mapping to solving biomedical and ... -
An adjustable algal chloroplast plug-and-play model for genome-scale metabolic models
(Peer reviewed; Journal article, 2020)The chloroplast is a central part of plant cells, as this is the organelle where the photosynthesis, fixation of inorganic carbon, and other key functions related to fatty acid synthesis and amino acid synthesis occur. ... -
Aerobic and anoxic biodegradability of amines applied in CO2-capture
(Journal article; Peer reviewed, 2017)Integrated and sustainable waste handling is becoming essential in large scale employment of amine-based post combustion CO2 capture and storage (CCS). We have previously proven the feasibility of biological nitrogen removal ... -
Algal Carotenoids: Chemistry, Sources, and Application
(Peer reviewed; Journal article, 2023)Recently, the isolation and identification of various biologically active secondary metabolites from algae have been of scientific interest, with particular attention paid to carotenoids, widely distributed in various ... -
Alginate and tunicate nanocellulose composite microbeads – Preparation, characterization and cell encapsulation
(Peer reviewed; Journal article, 2022)Alginate has been used for decades for cell encapsulation. Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production. We prepared ... -
Alginate Biosynthesis Factories in Pseudomonas fluorescens : Localization and Correlation with Alginate Production Level
(Journal article; Peer reviewed, 2016)Pseudomonas fluorescens is able to produce the medically and industrially important exopolysaccharide alginate. The proteins involved in alginate biosynthesis and secretion form a multiprotein complex spanning the inner ... -
Alginate Blocks and Block Polysaccharides: A Review
(Peer reviewed; Journal article, 2023)Alginates consist of distinct blocks with different physical properties. This short review focuses on research carried out in Trondheim related to the early discovery of the block structure, their isolation, their different ... -
Alginate gels crosslinked with chitosan oligomers - a systematic investigation into alginate block structure and chitosan oligomer interaction
(Peer reviewed; Journal article, 2021)Three alginates with fundamentally different block structures, poly-M, poly-G, and poly-MG, have been investigated upon ionic crosslinking with chitosan oligosaccharides (CHOS), using circular dichroism (CD), rheology, and ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
(Journal article; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood ... -
Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia
(Journal article; Peer reviewed, 2013)Islet transplantation in diabetes is hampered by the need of life-long immunosuppression. Encapsulation provides partial immunoprotection but could possibly limit oxygen supply, a factor that may enhance hypoxia-induced ... -
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
(Journal article; Peer reviewed, 2016)The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere ... -
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery
(Peer reviewed; Journal article, 2022)Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid ... -
Alginate-modifying enzymes: Biological roles and biotechnological uses
(Journal article; Peer reviewed, 2015)Alginate denotes a group of industrially important 1-4-linked biopolymers composed of the C-5-epimers β-D-mannuronic acid (M) and α-L-guluronic acid (G). The polysaccharide is manufactured from brown algae where it constitutes ... -
Alginates as Green Flocculants for Metal Oxide Nanoparticles
(Peer reviewed; Journal article, 2023)Flocculation is used for the removal or separation of colloids, e.g. in water treatment and mineral processing. Alginates are linear, anionic biopolymers composed of mannuronic (M) and guluronic (G) acids. The relative ... -
Alteration of hepato-lipidomic homeostasis in A/J mice fed an environmentally relevant PFAS mixture
(Peer reviewed; Journal article, 2023)In the present study, we have investigated liver lipid homeostasis and corresponding changes in transcript and functional product levels in A/J mice exposed to environmental relevant concentration of per- and polyfluoroalkyl ... -
An evolutionary preserved intergenic spacer in gadiform mitogenomes generates a long noncoding RNA
(Journal article; Peer reviewed, 2014)Background: Vertebrate mitogenomes are economically organized and usually lack intergenic sequences other than the control region. Intergenic spacers located between the tRNAThr and tRNAPro genes (“T-P spacers”) have been ... -
An orthogonal system for heterologous expression of actinobacterial lasso peptides in Streptomyces hosts
(Journal article; Peer reviewed, 2018)Lasso peptides are ribosomally synthesized and post-translationally modified peptides produced by bacteria. They are characterized by an unusual lariat-knot structure. Targeted genome scanning revealed a wide diversity of ... -
Anaerobic digestion of pig manure supernatant at high ammonia concentrations characterized by high abundances of Methanosaeta and non-euryarchaeotal archaea
(Journal article; Peer reviewed, 2017)We examined the effect of ammonium and temperature on methane production in high rate upflow anaerobic sludge bed reactors treating pig manure supernatant. We operated four reactors at two ammonium concentrations (‘low’ ... -
Analysis of G-Block Distributions and Their Impact on Gel Properties of in Vitro Epimerized Mannuronan
(Journal article; Peer reviewed, 2013)This paper reports a study of the distribution and function of homopolymeric guluronic acid blocks (G-blocks) in enzymatically modified alginate. High molecular weight mannuronan was incubated with one native (AlgE6) and ... -
Analytical Tools for Characterizing Cellulose-Active Lytic Polysaccharide Monooxygenases (LPMOs)
(Journal article; Peer reviewed, 2018)Lytic polysaccharide monooxygenases are copper-dependent enzymes that perform oxidative cleavage of glycosidic bonds in cellulose and various other polysaccharides. LPMOs acting on cellulose use a reactive oxygen species ...