Browsing by Author "Witter, Menno"
Now showing items 1-20 of 43
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A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation
Ito, Hiroshi; Zhang, Sheng Jia; Witter, Menno; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2015)Spatial navigation requires information about the relationship between current and future positions. The activity of hippocampal neurons appears to reflect such a relationship, representing not only instantaneous position ... -
Architecture and connectivity of the posterior parietal cortex of the rat
Olsen, Grethe Mari (Doctoral theses at NTNU;2017:29, Doctoral thesis, 2017) -
Architecture and Organization of Mouse Posterior Parietal Cortex Relative to Extrastriate Areas
Hovde, Karoline; Gianatti, Michele; Witter, Menno; Whitlock, Jonathan (Journal article; Peer reviewed, 2018)The posterior parietal cortex (PPC) is a multifaceted region of cortex, contributing to several cognitive processes including sensorimotor integration and spatial navigation. Although recent years have seen a considerable ... -
Architecture of spatial circuits in the hippocampal region
Witter, Menno; Canto, Cathrin Barbara; Couey, Jonathan Jay; Koganezawa, Noriko; O'Reilly, Kally (Journal article; Peer reviewed, 2014)The hippocampal region contains several principal neuron types, some of which show distinct spatial firing patterns. The region is also known for its diversity in neural circuits and many have attempted to causally relate ... -
Architecture of the entorhinal cortex A review of entorhinal anatomy in rodents with some comparative notes
Witter, Menno; Doan, Thanh Pierre; Nilssen, Eirik Stamland; Jacobsen, Bente; Ohara, Shinya (Journal article; Peer reviewed, 2017)The entorhinal cortex (EC) is the major input and output structure of the hippocampal formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes including two or many more subdivisions ... -
Comparative Contemplations on the Hippocampus
Witter, Menno; Kleven, Heidi; Kobro-Flatmoen, Asgeir (Journal article; Peer reviewed, 2017)The hippocampus in mammals is a morphologically well-defined structure, and so are its main subdivisions. To define the homologous structure in other vertebrate clades, using these morphological criteria has been difficult, ... -
Convergent projections from perirhinal and postrhinal cortices suggest a multisensory nature of lateral but not medial entorhinal cortex
Doan, Thanh Pierre; Donate Lagartos, Maria Jose; Nilssen, Eirik Stamland; Ohara, Shinya; Witter, Menno (Journal article; Peer reviewed, 2019)The current model of the organization of the medial temporal lobe (MTL) episodic memory system assumes that two functionally different “where” and “what” pathways enter MTL as parallel parahippocampal cortex (PHC)-medial ... -
Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex
Haugland, Kamilla Gjerland; Sugar, Jørgen; Witter, Menno (Journal article; Peer reviewed, 2019)The rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks ... -
Development of Parvalbumin-Expressing Basket Terminals in Layer II of the Rat Medial Entorhinal Cortex
Berggaard, Nina; Bjerke, Ingvild Elise; Paulsen, Anna Elisabeth Bråthen; Hoang, Linh; Skogaker, Nan Elisabeth Tostrup; Witter, Menno; Van der Want, Johannes (Journal article; Peer reviewed, 2018)Grid cells in layer II of the medial entorhinal cortex (MEC LII) generate multiple regular firing fields in response to the position and speed of an individual within the environment. They exhibit a protracted postnatal ... -
Digital atlas of anatomical subdivisions and boundaries of the rat hippocampal region
Kjønigsen, Lisa Jannicke; Leergaard, Trygve Brauns; Witter, Menno; Bjaalie, Jan G. (Journal article; Peer reviewed, 2011)The rat hippocampal region is frequently studied in relation to learning and memory processes and brain diseases. The region is complex, consisting of multiple subdivisions that are challenging to delineate anatomically. ... -
Electrophysiological characterization of networks and single cells in the hippocampal region of a transgenic rat model of Alzheimer’s disease
Heggland, Ingrid; Kvello, Pål; Witter, Menno (Journal article; Peer reviewed, 2019)The hippocampus and entorhinal cortex (EC) are areas affected early and severely in Alzheimer’s disease (AD), and this is associated with deficits in episodic memory. Amyloid-β (Aβ), the main protein found in amyloid ... -
Entorhinal fast-spiking speed cells project to the hippocampus
Ye, Jing; Witter, Menno; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2018)The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in ... -
Entorhinal layer II calbindin-expressing neurons originate widespread telencephalic and intrinsic projections
Ohara, Shinya; Gianatti, Michele; Itou, Kazuki; Berndtsson, Christin Høiberget; Doan, Thanh Pierre; Kitanishi, Takuma; Mizuseki, Kenju; Ijima, Toshio; Tsutsui, Ken-Ishiro; Witter, Menno (Journal article; Peer reviewed, 2019)In the present study we provide the first systematic and quantitative hodological study of the calbindin-expressing (CB+) principal neurons in layer II of the entorhinal cortex and compared the respective projections of ... -
Functional organization of the hippocampal longitudinal axis
Strange, B; Witter, Menno; Lein, Ed S.; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2014)The precise functional role of the hippocampus remains a topic of much debate. The dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial navigation and the ventral (or anterior) ... -
GABAA receptor subunit α3 in network dynamics in the medial entorhinal cortex
Berggaard, Nina; Witter, Menno; van der Want, Johannes Jacobus Leendert (Journal article; Peer reviewed, 2019)Layer II of the medial entorhinal cortex (MEC LII) contains the largest number of spatially modulated grid cells and is one of the first regions in the brain to express Alzheimer’s disease (AD)-related pathology. The most ... -
Grid cells and cortical representation
Moser, Edvard Ingjald; Roudi, Yasser; Witter, Menno; Kentros, Clifford; Bonhoeffer, Tobias; Moser, May-Britt (Journal article; Peer reviewed, 2014)One of the grand challenges in neuroscience is to comprehend neural computation in the association cortices, the parts of the cortex that have shown the largest expansion and differentiation during mammalian evolution and ... -
Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex
Miao, Chenglin; Cao, Qichen; Ito, Hiroshi; Yamahachi, Homare; Witter, Menno; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2015)Hippocampal place cells undergo remapping when the environment is changed. The mechanism of hippocampal remapping remains elusive but spatially modulated cells in the medial entorhinal cortex (MEC) have been identified as ... -
Immunohistochemical and morphological characterization of GABAergic cells in LEC
Phan, Ailan (Master thesis, 2015)The two subdivisions of the entorhinal cortex, the medial and the lateral entorhinal cortex have been implicated a crucial role in spatial cognition but appear to be functionally distinct. To understand the functional ... -
Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex
Nilssen, Eirik Stamland; Jacobsen, Bente; Fjeld, Gunhild; Nair, Rajeevkumar Raveendran; Blankvoort, Stefan; Kentros, Clifford; Witter, Menno (Journal article; Peer reviewed, 2018)Fan cells in layer II of the lateral entorhinal cortex (LEC) form a main component of the projection to the dentate gyrus, CA3 and CA2 of the hippocampal formation. This projection has a counterpart originating from stellate ... -
Interaction of nucleus reuniens and entorhinal cortex projections in hippocampal field CA1 of the rat
Dolleman-van der Weel, M. J.; Lopes da Silva, F.H.; Witter, Menno (Journal article; Peer reviewed, 2016)The nucleus reuniens (RE) and entorhinal cortex (EC) provide monosynaptic excitatory inputs to the apical dendrites of pyramidal cells and to interneurons with dendrites in stratum lacunosum moleculare (LM) of hippocampal ...