Blar i NTNU Open på forfatter "Witter, Menno"
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Functional organization of the hippocampal longitudinal axis
Strange, B; Witter, Menno; Lein, Ed S.; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2014)The precise functional role of the hippocampus remains a topic of much debate. The dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial navigation and the ventral (or anterior) ... -
GABAA receptor subunit α3 in network dynamics in the medial entorhinal cortex
Berggaard, Nina; Witter, Menno; van der Want, Johannes Jacobus Leendert (Journal article; Peer reviewed, 2019)Layer II of the medial entorhinal cortex (MEC LII) contains the largest number of spatially modulated grid cells and is one of the first regions in the brain to express Alzheimer’s disease (AD)-related pathology. The most ... -
Grid cells and cortical representation
Moser, Edvard Ingjald; Roudi, Yasser; Witter, Menno; Kentros, Clifford; Bonhoeffer, Tobias; Moser, May-Britt (Journal article; Peer reviewed, 2014)One of the grand challenges in neuroscience is to comprehend neural computation in the association cortices, the parts of the cortex that have shown the largest expansion and differentiation during mammalian evolution and ... -
High-resolution structural analysis of layer II principal neurons in the entorhinal cortex
Moan, Kristian (Master thesis, 2021)Entorhinal cortex (EC), bestående av mediale entorhinal cortex (MEC) or lateral entorhinal cortex (LEC), mottar et rikt utvalg av kortikale signaler. Her formes og kodes signalene inn i et relevant «språk» før de, gjennom ... -
Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex
Miao, Chenglin; Cao, Qichen; Ito, Hiroshi; Yamahachi, Homare; Witter, Menno; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2015)Hippocampal place cells undergo remapping when the environment is changed. The mechanism of hippocampal remapping remains elusive but spatially modulated cells in the medial entorhinal cortex (MEC) have been identified as ... -
Immunohistochemical and morphological characterization of GABAergic cells in LEC
Phan, Ailan (Master thesis, 2015)The two subdivisions of the entorhinal cortex, the medial and the lateral entorhinal cortex have been implicated a crucial role in spatial cognition but appear to be functionally distinct. To understand the functional ... -
Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex
Nilssen, Eirik Stamland; Jacobsen, Bente; Fjeld, Gunhild; Nair, Rajeevkumar Raveendran; Blankvoort, Stefan; Kentros, Clifford; Witter, Menno (Journal article; Peer reviewed, 2018)Fan cells in layer II of the lateral entorhinal cortex (LEC) form a main component of the projection to the dentate gyrus, CA3 and CA2 of the hippocampal formation. This projection has a counterpart originating from stellate ... -
The inside-out of Alzheimer’s disease
Bjørkli, Christiana Lucinda (Doctoral theses at NTNU;2022:222, Doctoral thesis, 2022)Every three seconds someone is diagnosed with dementia, and Alzheimer’s disease (AD) constitutes most of these cases. In the absence of a cure for AD, testing hypotheses regarding disease onset and spread, and developing ... -
Interaction of nucleus reuniens and entorhinal cortex projections in hippocampal field CA1 of the rat
Dolleman-van der Weel, M. J.; Lopes da Silva, F.H.; Witter, Menno (Journal article; Peer reviewed, 2016)The nucleus reuniens (RE) and entorhinal cortex (EC) provide monosynaptic excitatory inputs to the apical dendrites of pyramidal cells and to interneurons with dendrites in stratum lacunosum moleculare (LM) of hippocampal ... -
Intrinsic Connectivity of the Claustrum: Gap Junctions Demonstrated by Immunohistochemistry and Electron Microscopy
Bennett, Peter (Master thesis, 2014)The claustrum is a much neglected nucleus in the brain, whose fuction remains unknown to date. Yet, based on the extensive reciprocal connections it shares with virtually all functional regions of cortex, it most likely ... -
Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat
Witter, Menno; Ohara, Shinya; Onodera, Mariko; Simonsen, Øyvind Wilsgård; Yoshino, Rintaro; Hioki, Hiroyuki; Iijima, Toshio; Tsutsui, Ken-Ichiro (Journal article; Peer reviewed, 2018)Layer V of the entorhinal cortex (EC) receives input from the hippocampus and originates main entorhinal outputs. The deep-sublayer Vb, immunopositive for the transcription factor Ctip2, is thought to be the main recipient ... -
Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
Ohara, Shinya; Blankvoort, Stefan; Nair Raveendran, Rajeevkumar; Nigro, Maximiliano Jose; Nilssen, Eirik Stamland; Kentros, Clifford; Witter, Menno (Peer reviewed; Journal article, 2021)The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a ... -
MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex
Olsen, Lene Christin; O'Reilly, Kally; Liabakk, Nina-Beate; Witter, Menno; Sætrom, Pål (Journal article; Peer reviewed, 2017)The medial entorhinal cortex (MEC) is important in spatial navigation and memory formation and its layers have distinct neuronal subtypes, connectivity, spatial properties, and disease susceptibility. As little is known ... -
miRNA and mRNA expression in the hippocampal region during postnatal developments in rats
Olsen, Lene Christin (Doctoral theses at NTNU;2018:66, Doctoral thesis, 2018)Hjernestrukturene entorhinal cortex og hippocampus er viktige for minnefunksjon og navigering. Innenfor hver av disse strukturene finnes underregioner som har forskjellige celletyper og forbindelser i hjernen. Noen av ... -
Neuronal chemo‐architecture of the entorhinal cortex: A comparative review
Kobro-Flatmoen, Asgeir; Witter, Menno (Journal article; Peer reviewed, 2019)The identification of neuronal markers, that is, molecules selectively present in subsets of neurons, contributes to our understanding of brain areas and the networks within them. Specifically, recognizing the distribution ... -
Neurons and networks in the entorhinal cortex: A reappraisal of the lateral and medial entorhinal subdivisions mediating parallel cortical pathways
Nilssen, Eirik Stamland; Doan, Thanh Pierre; Nigro, Maximiliano Jose; Ohara, Shinya; Witter, Menno (Journal article; Peer reviewed, 2019)In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, ... -
Organization of multisynaptic inputs to the dorsal and ventral dentate gyrus: retrograde trans-synaptic tracing with rabies virus vector in the rat
Ohara, S; Sato, S; Tsutsui, K; Witter, Menno; Iijima, Toshio (Journal article; Peer reviewed, 2013)Behavioral, anatomical, and gene expression studies have shown functional dissociations between the dorsal and ventral hippocampus with regard to their involvement in spatial cognition, emotion, and stress. In this study ... -
Organization of Posterior Parietal–Frontal Connections in the Rat
Olsen, Grethe Mari; Hovde, Karoline; Kondo, Hideki; Sakshaug, Teri; Haaland Sømme, Hanna; Whitlock, Jonathan; Witter, Menno (Journal article; Peer reviewed, 2019)Recent investigations of the rat posterior parietal cortex (PPC) suggest that this region plays a central role in action control together with the frontal cortical areas. Posterior parietal-frontal cortical connections ... -
Parahippocampal and retrosplenial connections of rat posterior parietal cortex
Olsen, Grethe Mari; Ohara, Shinya; Iijima, Toshio; Witter, Menno (Journal article; Peer reviewed, 2017)The posterior parietal cortex has been implicated in spatial functions, including navigation. The hippocampal and parahippocampal region and the retrosplenial cortex are crucially involved in navigational processes and ... -
Perirhinal firing patterns are sustained across large spatial segments of the task environment
Bos, Jeroen J.; Vinck, Martin; van Mourik-Donga, Laura; Jackson, Jadin C.; Witter, Menno; Pennartz, Cyriel M.A. (Journal article; Peer reviewed, 2017)Spatial navigation and memory depend on the neural coding of an organism’s location. Fine-grained coding of location is thought to depend on the hippocampus. Likewise, animals benefit from knowledge parsing their environment ...