Blar i NTNU Open på forfatter "Westhrin, Marita"
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Beauty and the Beast: The Multifaceted Potential of Mesenchymal Stem Cells in Bone Health and Disease
Westhrin, Marita (Doctoral thesis at NTNU;2015:171, Doctoral thesis, 2015)Mesenkymale stamceller: Biologi og terapeutisk potensiale: Skjelettet er det som holder kroppen vår oppe, beskytter organene våre og det er samtidig en viktig kilde for kalsium og fosfater. Humant beinvev består av en ... -
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone
Westhrin, Marita; Holien, Toril; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; de Bruijn, Joost D; Martens, Anton; Groen, Richard WJ; Bosch, Fátima; Smith, Ulf; Sponaas, Anne-Marit; Sundan, Anders; Standal, Therese (Peer reviewed; Journal article, 2020)Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation. Bone ... -
Caspase-8 regulates the expression of pro- and anti-inflammatory cytokines in human bone marrow-derived mesenchymal stromal cells
Moen, Siv Helen; Westhrin, Marita; Zahoor, Muhammad; Nikolai N., Nørgaard; Hella, Hanne; Størdal, Berit Fladvad; Sundan, Anders; Nilsen, Nadra J.; Sponaas, Anne-Marit; Standal, Therese (Journal article; Peer reviewed, 2016)Introduction: Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great potential in stem cell therapy partly due to their immunosuppressive properties. How these cells respond to chronic inflammatory ... -
Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
Westhrin, Marita; Moen, Siv Helen; Kristensen, Ida Bruun; Buene, Glenn; Mylin, Anne Kærsgaard; Turesson, Ingemar; Abildgaard, Niels; Waage, Anders; Standal, Therese (Journal article; Peer reviewed, 2018)Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it ... -
Differentiation and Bone Deposition of Bone Marrow Derived Stem Cells on Additive Manufactured Porous Ti-6Al-4V Scaffolds
Jøraholmen, Timothy (Master thesis, 2017)The number of arthroplasty surgeries, or joint replacing surgeries, being performed each year is increasing worldwide. Younger patients are also being increasingly introduced to this kind of surgery, which means that the ... -
Encapsulation of Human Mesenchymal Stem Cells in Phosphate Mineralized Alginate Beads
Westhrin, Marita (Master thesis, 2011)Alginate scaffolds show good promise for bone tissue engineering using stem cells. This is due to the fact that alginate is biocompatible, non-immunogenic, and in addition may direct differentiation of stem cells into a ... -
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss
Zahoor, Muhammad; Westhrin, Marita; Aass, Kristin Roseth; Moen, Siv Helen; Misund, Kristine; Psonka-Antonczyk, Katarzyna Maria; Giliberto, Mariaserena; Buene, Glenn; Sundan, Anders; Waage, Anders; Sponaas, Anne-Marit; Standal, Therese (Journal article; Peer reviewed, 2017)Multiple myeloma (MM) is a hematologic cancer characterized by expansion of malignant plasma cells in the bone marrow. Most patients develop an osteolytic bone disease, largely caused by increased osteoclastogenesis. The ... -
In vitro differentiation of osteoclasts - Studying the effect of myeloma derived immunoglobulins on osteoclastogenesis after optimizing the culturing process
Nilsen, Helene (Master thesis, 2016)Multiple myeloma is a hematological cancer caused by accumulation of malignant plasma cells in the bone marrow with extensive bone destruction and heavily decreased bone formation. Osteoclasts are terminally differentiated, ... -
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells
Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca M; Roseth, Ingrid Aass; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Nedal, Tonje Marie Vikene; Buene, Glenn; Misund, Kristine; Sponaas, Anne-Marit; Ma, Qianli; Sundan, Anders; Groen, Richard WJ; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese (Journal article; Peer reviewed, 2021)Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), ... -
New players in an old game: Role of immunoglobulins in the pathogenesis of multiple myeloma
Kovcic, Vlado (Doctoral theses at NTNU;2020:124, Doctoral thesis, 2020)Multiple myeloma is a haematological malignancy characterized by uncontrolled proliferation of malignant plasma cells. The myeloma cells secrete immunoglobulins, which leads to the presence of high levels of monoclonal ... -
Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices
Westhrin, Marita; Xie, Minli; Olderøy, Magnus Ø.; Sikorski, Pawel; Strand, Berit Løkensgard; Standal, Therese (Journal article; Peer reviewed, 2015)Mineralized biomaterials are promising for use in bone tissue engineering. Culturing osteogenic cells in such materials will potentially generate biological bone grafts that may even further augment bone healing. Here, ... -
The osteogenic properties of additive manufactured Titanium-6Aluminium-4Vanadium with focus on 3D geometry and surface topography
Ødegaard, Kristin Sirnes (Doctoral theses at NTNU;2023:77, Doctoral thesis, 2023) -
Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells
Ødegaard, Kristin Sirnes; Ouyang, Lingzi; Ma, Qianli; Buene, Glenn; Wan, Di; Elverum, Christer Westum; Torgersen, Jan; Standal, Therese; Westhrin, Marita (Peer reviewed; Journal article, 2021)Porous Titanium-6Aluminum-4Vanadium scaffolds made by electron beam-based additive manufacturing (AM) have emerged as state-of-the-art implant devices. However, there is still limited knowledge on how they influence the ... -
The Role of IL-32 in Multiple Myeloma
Aass, Kristin Roseth (Doctoral theses at NTNU;2020:256, Doctoral thesis, 2020) -
Smac-mimetics reduce numbers and viability of human osteoclasts
Moen, Ingrid Nyhus; Westhrin, Marita; Håland, Erling; Haug, Markus; Nonstad, Unni; Klaharn, Merisa; Standal, Therese; Starheim, Kristian K. (Peer reviewed; Journal article, 2021)Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. ... -
The Biocompatibility and Osteogenic Properties of Additive Manufactured Porous Ti-6Al-4V Scaffolds
Ødegaard, Kristin Sirnes (Master thesis, 2018)Human bone is constantly being remodeled, and has the ability to repair itself when damage occurs. However, sometimes the fractures are so intense that they exceed the critical non-healable size. In order to repair such ...