Blar i NTNU Open på forfatter "Wang, S"
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Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers
Wang, S; Liu, Z; Ye, T*; Mabrouk, O S; Maltbie, T; Aasly, Jan; West, A B (Journal article; Peer reviewed, 2017)Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2 autophosphorylation at ... -
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells
Wang, Q; Chen, Q; Zhu, L; Chen, M; Xu, W; Panday, S; Wang, Z; Li, A; Røe, Oluf Dimitri; Chen, R; Wang, S; Zhang, R; Zhou, J (Journal article; Peer reviewed, 2017)Platinum chemotherapeutics are widely used to treat solid malignant tumors, including gastric cancer (GC). Drug resistance to platinum compounds may result in cancer relapse and decreased survival. The identification and ... -
JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells
Xu, W; Chen, Q; Wang, Q; Sun, Y; Wang, S; Li, A; Xu, S; Røe, Oluf Dimitri; Wang, R; Zhang, R.; Yang, L; Zhou, J. (Journal article; Peer reviewed, 2014)Gastric cancer is the third most common malignancy in China, with a median 5-year survival of only 20%. Cisplatin has been used in first-line cancer treatment for several types of cancer including gastric cancer. However, ... -
TXNL1-XRCC1 pathway regulates cisplatin-induced cell death and contributes to resistance in human gastric cancer
Xu, W; Wang, S; Chen, Q; Zhang, Y; Ni, P; Wu, X; Zhang, J; Qiang, F; Li, A; Røe, Oluf Dimitri; Xu, S; Wang, M; Zhang, R.; Zhou, J. (Journal article; Peer reviewed, 2014)Cisplatin is a cytotoxic platinum compound that triggers DNA crosslinking induced cell death, and is one of the reference drugs used in the treatment of several types of human cancers including gastric cancer. However, ...