Browsing NTNU Open by Author "Waldum, Helge"
Now showing items 1-20 of 35
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Adverse effects of proton pump inhibitors – evidence and plausibility
Fossmark, Reidar; Martinsen, Tom Christian; Waldum, Helge (Journal article; Peer reviewed, 2019)Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential ... -
Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis
Fossmark, Reidar; Qvigstad, Gunnar; Martinsen, Tom Christian; Hauso, Øyvind; Waldum, Helge (Journal article; Peer reviewed, 2011)Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused ... -
The central role of gastrin in gastric cancer
Waldum, Helge; Mjønes, Patricia Gjertrud (Peer reviewed; Journal article, 2023)The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ... -
Chronic diseases: what about infections of virus and prions via the gut?
Waldum, Helge; Martinsen, Tom Christian (Peer reviewed; Journal article, 2021) -
Correct Identification of Cell of Origin may Explain Many Aspects of Cancer: The role of Neuroendocrine Cells as Exemplfied from the Stomach
Waldum, Helge; Mjønes, Patricia (Peer reviewed; Journal article, 2020)Cancers are believed to originate from stem cells. Previously, the hypothesis was that tumors developed due to dedifferentiation of mature cells. We studied the regulation of gastric acid secretion and showed that gastrin ... -
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation
Østvik, Ann Elisabet; Granlund, Atle; Bugge, Marit; Nilsen, Nadra; Torp, Sverre Helge; Waldum, Helge; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian (Journal article, 2013)We explored the gene expression in colonic biopsies of active and inactive inflammatory bowel disease (IBD), in an extensive material of ulcerative colitis (UC) and Crohn`s disease (CD). The chemokine CXCL10 and its receptor ... -
Expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma
Mjønes, Patricia; Nordrum, Ivar Skjåk; Qvigstad, Gunnar; Sørdal, Øystein Finset; Rian, Liselotte Linnea Mårtensson; Waldum, Helge (Journal article; Peer reviewed, 2017)The aim of the study was to investigate the expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma (CCRCC). We retrospectively reviewed the medical records and re-evaluated histopathological ... -
Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells
Mjønes, Patricia; Nordrum, Ivar Skjåk; Sørdal, Øystein Finset; Sagatun, Liv; Fossmark, Reidar; Sandvik, Arne Kristian; Waldum, Helge (Journal article, 2017)Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In ... -
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge; Flo, Trude Helen; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2013)Anti-microbial peptides might influence the pathogenesis and course of inflammatory bowel disease (IBD). We sought to clarify the role of the anti-microbial glycoprotein lipocalin 2 (LCN2) in the colon by determining its ... -
Forekomst av kolorektalkreft i en 5-års periode etter negativ colonoscopi, eller etter påvist adenomatøs polypp
Vallner, Sindre (Master thesis, 2013)Introduksjon: Norge har i dag den høyeste forekomsten av CRC i Norden. Insidensen av CRC har i mange tiår vært økende, men tall fra det siste tiåret viser stabilisering. Gullstandarden for å diagnostisere CRC og premaligne ... -
Gastric Carcinomas Localized to the Cardia
Bakkelund, Karin Elvenes; Nordrum, Ivar Skjåk; Fossmark, Reidar; Waldum, Helge (Journal article; Peer reviewed, 2012)Objectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading ... -
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
Aasarød, Kristin Matre; Waldum, Helge; Stunes, Astrid Kamilla; Sandvik, Arne Kristian; Flatberg, Arnar; Mjønes, Patricia; Syversen, Unni; Bakke, Ingunn; Fossmark, Reidar (Journal article; Peer reviewed, 2020)Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ... -
Gastrin and gastric cancer
Waldum, Helge; Sagatun, Liv; Mjønes, Patricia (Journal article; Peer reviewed, 2017)Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced ... -
Gastritis, Gastric Polyps and Gastric Cancer
Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2021)Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction ... -
Hepatic micrometastases outside macrometastases are present in all patients with ileal neuroendocrine primary tumour at the time of liver resection.
Fossmark, Reidar; Balto, Tine Marie; Martinsen, Tom Christian; Grønbech, Jon Erik; Munkvold, Bjørn; Mjønes, Patricia; Waldum, Helge (Journal article; Peer reviewed, 2019)Background: Neuroendocrine tumours (NETs) in the ileum grow slowly but metastasise to the liver at an early stage. After resection of the primary tumour and mesenteric lymph nodes, selected patients with liver metastases ... -
Hormones and Neuroendocrine Cells Role in Gastric Tumourigenesis
Sagatun, Liv (Doctoral theses at NTNU;2017:177, Doctoral thesis, 2017)The localization of the gastrin receptor on the enterochromaffin-like (ECL) cells and the dose-response curve for the histamine releasing effect of gastrin have been shown in rats. Furthermore, in this species the trophic ... -
Hypergastrinemia and mortality in gastric adenocarcinoma: a population-based cohort study, the HUNT study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Purpose: Hypergastrinemia increases the risk of developing proximal gastric adenocarcinoma. However, it is unclear if hypergastrinemia affects the survival in patients with gastric adenocarcinoma. This study aimed to examine ... -
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mattsson, Fredrik; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2020)The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of our study was therefore to assess ... -
Inflammation and Digestive Cancer
Waldum, Helge; Fossmark, Reidar (Journal article; Peer reviewed, 2023)Chronic inflammation is linked to carcinogenesis, particularly in the digestive organs, i.e., the stomach, colon, and liver. The mechanism of this effect has, however, only partly been focused on. In this review, we focus ... -
Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
Yang, Hang; Qi, Haili; Ren, Jingli; Cui, Jing; Li, Zhenfeng; Waldum, Helge; Guanglin, Cui (Journal article; Peer reviewed, 2014)Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession ...