Browsing NTNU Open by Author "Waldum, Helge"
Now showing items 21-36 of 36
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Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
Yang, Hang; Qi, Haili; Ren, Jingli; Cui, Jing; Li, Zhenfeng; Waldum, Helge; Guanglin, Cui (Journal article; Peer reviewed, 2014)Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession ... -
Neuron-Specific Enolase as an Immunohistochemical Marker Is Better Than Its Reputation
Mjønes, Patricia; Sagatun, Liv; Nordrum, Ivar Skjåk; Waldum, Helge (Journal article; Peer reviewed, 2017)The diagnosis of neuroendocrine neoplasms (NENs) may be challenging and is based on typical morphological features and positive staining for antibodies of neuroendocrine differentiation. Neuron-specific enolase (NSE) being ... -
Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift
Waldum, Helge; Öberg, Kjell; Sørdal, Øystein Finset; Sandvik, Arne Kristian; Gustafsson, Björn; Mjønes, Patricia; Fossmark, Reidar (Journal article; Peer reviewed, 2018)Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is ... -
Pharmacokinetics of single and repeated oral doses of esomeprazole and gastrin elevation in healthy males and females
Helgadottir, Holmfridur; Lund, Sigrun H; Gizurason, Sveinbjørn; Waldum, Helge; Björnsson, Einar B (Peer reviewed; Journal article, 2020)Objective Gastrin elevation secondary to proton pump inhibitor (PPI) therapy is well documented. Recent studies have demonstrated a sex-related difference where females on PPIs have significantly higher baseline gastrin ... -
Role of Autoimmune Gastritis in Gastric Cancer
Waldum, Helge; Fossmark, Reidar (Journal article; Peer reviewed, 2019)It has been known for 70 years that gastric cancer occurs mainly in a stomach with gastritis. Gastritis was previously so prevalent that it was regarded as an aging phenomenon. Since the description of Helicobacter pylori ... -
Serotonin and the cardiovascular system
Zeinali, Fatemeh (Doktoravhandlinger ved NTNU, 1503-8181; 2014:310, Doctoral thesis, 2014)Serotonin (5-HT) is a biogenic amine with diverse effects in the central nervous system as well as in the periphery. It regulates vascular biology, ranging from the control of vascular resistance and blood pressure to ... -
Serotonin—A Driver of Progressive Heart Valve Disease
Waldum, Helge; Wahba, Alexander (Peer reviewed; Journal article, 2022)It is well known that some serotoninergic drugs and neuroendocrine tumors producing serotonin (5-HT) may induce valvular heart disease by stimulation of proliferation of valvular cells via interaction with a 5-HT receptor ... -
Symptomatic primary (Al) amyloidosis of the stomach and duodenum.
Fossmark, Reidar; Skarsvåg, Espen; Aarset, Harald; Hjort-Hansen, Henrik; Waldum, Helge (Journal article; Peer reviewed, 2013)Primary (AL) amyloidosis of the gastrointestinal tract is relatively rare, and symptomatic amyloidosis of the stomach is even more seldom. We present the case of a patient who was referred to upper endoscopy because of ... -
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
Vange, Pål; Bruland, Torunn; Doseth, Berit; Fossmark, Reidar; Sousa, Mirta; Beisvag, Vidar; Sørdal, Øystein Finset; Qvigstad, Gunnar; Waldum, Helge; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2017)The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated ... -
The enterochromaffin-like [ECL] cell-central in gastric physiology and pathology
Waldum, Helge; Sørdal, Øystein Finset; Mjønes, Patricia (Journal article; Peer reviewed, 2019)Background: Studies on the regulation of gastric and pancreatic secretion began more than 100 years ago. Secretin was the first hormone postulated to exist, initiating the field of endocrinology. Gastrin produced in the ... -
The phylogeny and biological function of gastric juice-microbiological consequences of removing gastric acid
Martinsen, Tom Christian; Fossmark, Reidar; Waldum, Helge (Journal article; Peer reviewed, 2019)Gastric juice is a unique combination of hydrochloric acid (HCl), lipase, and pepsin. Acidic gastric juice is found in all vertebrates, and its main function is to inactivate microorganisms. The phylogenetic preservation ... -
Time to classify tumours of the stomach and the kidneys according to cell of origin
Waldum, Helge; Mjønes, Patricia (Peer reviewed; Journal article, 2021)Abstract: Malignant tumours are traditionally classified according to their organ of origin and whether they are of epithelial (carcinomas) or mesenchymal (sarcomas) origin. By histological appearance the site of origin ... -
Towards understanding of gastric cancer based upon physiological role of gastrin and ECL cells
Waldum, Helge; Mjønes, Patricia (Peer reviewed; Journal article, 2020)The stomach is an ideal organ to study because the gastric juice kills most of the swallowed microbes and, thus, creates rather similar milieu among individuals. Combined with a rather easy access to gastric juice, gastric ... -
Tumor classification should be based on biology and not consensus: Re-defining tumors based on biology may accelerate progress, an experience of gastric cancer
Waldum, Helge (Journal article; Peer reviewed, 2021)Abstract: Malignant tumors are a consequence of genetic changes mainly occurring during cell division, sometimes with a congenital component. Therefore, accelerated cell divisions will necessarily predispose individuals, ... -
Types of Gastric Carcinomas
Waldum, Helge; Fossmark, Reidar (Journal article; Peer reviewed, 2018)Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers are typically localized to one of the three mucosae; ... -
Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis
Granlund, Atle Van Beelen; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, Ignat; Gustafsson, Björn; Kidd, Mark; Beisvag, Vidar; Torp, Sverre Helge; Waldum, Helge; Martinsen, Tom Christian; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2013)Background: In inflammatory bowel disease (IBD), genetic susceptibility together with environmental factors disturbs gut homeostasis producing chronic inflammation. The two main IBD subtypes are Ulcerative colitis (UC) ...