Browsing NTNU Open by Author "Wahl, Sissel Gyrid Freim"
Now showing items 1-12 of 12
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Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA
Dunwell, Thomas L.; Dailey, Simon C.; Ottestad, Anine Larsen; Yu, Jihang; Becker, Philipp W.; Scaife, Sarah; Richman, Susan D.; Wood, Henry M.; Slaney, Hayley; Bottomley, Daniel; Yang, Xiangsheng; Xiao, Hui; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Dai, Hong Yan; Fu, Guoliang (Peer reviewed; Journal article, 2021)Liquid biopsy testing utilising Next Generation Sequencing (NGS) is rapidly moving towards clinical adoption for personalised oncology. However, before NGS can fulfil its potential any novel testing approach must identify ... -
Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions
Tøndell, Anders; Subbannayya, Yashwanth; Wahl, Sissel Gyrid Freim; Flatberg, Arnar; Sørhaug, Sveinung; Børset, Magne; Haug, Markus (Peer reviewed; Journal article, 2021)Lung cancer is the leading cause of cancer-related death worldwide, accounting for nearly one-fifth of all cancer-related deaths. Immunotherapy with immune checkpoint inhibitors has become one of the most promising approaches ... -
Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study
Sun, Yi-Qian; Richmond, Rebecca C.; Suderman, Matthew; Min, Josine L; Battram, Thomas; Flatberg, Arnar; Beisvag, Vidar; Nøst, Therese Haugdahl; Guida, Florence; Jiang, Lin; Wahl, Sissel Gyrid Freim; Langhammer, Arnulf; Skorpen, Frank; Walker, Rosie M; Bretherick, Andrew D; Zeng, Yanni; Chen, Yue; Johansson, Mattias; Sandanger, Torkjel M; Relton, Caroline L; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)Background: It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel smoking-related DNA methylation sites in blood, with repeated ... -
Associations between tumor mutations in cfDNA and survival in non-small cell lung cancer
Ottestad, Anine Larsen; Hong, Yan Dai; Halvorsen, Tarje Onsøien; Emdal, Elisabeth Fritzke; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2021)Introduction: Studies have indicated that detection of mutated KRAS or EGFR in circulating tumor DNA (ctDNA) from pre-treatment plasma samples is a negative prognostic factor for non-small cell lung cancer (NSCLC) pa-tients. ... -
Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
Jiang, Lin; Sun, Yi-Qian; Langhammer, Arnulf; Brumpton, Ben Michael; Chen, Yu; Nilsen, Tom Ivar Lund; Leivseth, Linda; Wahl, Sissel Gyrid Freim; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported ... -
Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non–small-cell Lung Cancer
Tøndell, Anders; Wahl, Sissel Gyrid Freim; Sponaas, Anne-Marit; Sørhaug, Sveinung; Børset, Magne; Haug, Markus (Journal article; Peer reviewed, 2019)Lung cancer is the leading cause of cancer death in both sexes worldwide and has a predicted 5-year survival rate of <20%. Immunotherapy targeting immune checkpoints such as the programmed death 1 (PD-1) signaling pathway ... -
Increase in curative treatment and survival of lung cancer in Norway 2001-2016
Solberg, Steinar; Nilssen, Yngvar; Brustugun, Odd Terje; Grimsrud, Tom Kristian; Haram, Per Magnus; Helbekkmo, Nina; Helland, Åslaug; Hjelde, Harald Harris; Jakobsen, Bjørn; Møller, Bjørn; Petersen, Martin; Strand, Trond-Eirik; Wahl, Sissel Gyrid Freim; Aanerud, Marianne; Fjellbirkeland, Lars (Peer reviewed; Journal article, 2019)We have studied the alterations in the use of curative treatment and the outcome for lung cancer patients in Norway 2001–2016. The Cancer Registry of Norway has a practically complete registration of all cancer diagnoses, ... -
The prognostic effect of KRAS mutations in non-small cell lung carcinoma revisited: A norwegian multicentre study
Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Berg, Thomas; Halvorsen, Tarje Onsøien; Ottestad, Anine Larsen; Lund-Iversen, Marius; Brustugun, Odd; Førde, Dagny; Paulsen, Erna-Elise; Donnem, Tom; Andersen, Sigve; Grønberg, Bjørn Henning; Richardsen, Elin (Peer reviewed; Journal article, 2021)Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate ... -
Prognostic value of absolute quantification of mutated KRAS in circulating tumour DNA in lung adenocarcinoma patients prior to therapy
Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Ottestad, Anine Larsen; Dale, Vibeke Grotnes; Richardsen, Elin; Halvorsen, Tarje Onsøien; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2021)Droplet digital polymerase chain reaction (ddPCR) is a highly sensitive and accurate method for quantication of nucleic acid sequences. We used absolute quantication of mutated v-Ki-ras2 Kirsten rat sarcoma viral oncogene ... -
The prognostic value of KRAS in circulating cell-free DNA and tumour tissue in patients with non-small cell lung cancer
Wahl, Sissel Gyrid Freim (Doctoral theses at NTNU;2021:315, Doctoral thesis, 2021) -
The relevance of tumor mutation profiling in interpretation of NGS data from cell-free DNA in non-small cell lung cancer patients
Ottestad, Anine Larsen; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Skorpen, Frank; Dai, Hong Yan (Journal article; Peer reviewed, 2019)Studies have indicated that detection of circulating tumor DNA (ctDNA) prior to treatment is a negative prognostic marker in non-small cell lung cancer (NSCLC). ctDNA is currently identified by detection of tumor mutations. ... -
The undifferentiated carcinoma that became a melanoma: Re-biopsy of a cancer of an unknown primary site: a case report.
Røe, Oluf Dimitri; Wahl, Sissel Gyrid Freim (Journal article; Peer reviewed, 2017)Background Cancer of unknown primary site is still a demanding condition as it is per definition metastatic, with heterogeneous biological behavior, and it is often resistant to therapy. Cancer of unknown primary site ...