Browsing NTNU Open by Author "Tunset, Hanna Maja"
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A novel compound isolated from Sclerochloa dura has anti-inflammatory effects
Bukhari, Syed Majid; Feuerherm, Astrid Jullumstrø; Tunset, Hanna Maja; Isaksen, Stian Moe; Sæther, Mari; Thvedt, Thor Håkon Krane; Villa Gonzalez, Susana; Schmid, Rudolf; Brunsvik, Anders; Fuglseth, Erik; Zlatković, Bojan; Johansen, Berit; Simic, Nebojsa (Journal article; Peer reviewed, 2016)The activation of phospholipase A2 (PLA2) by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. Through cyclooxygenases ... -
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model
Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø; Engebråten, Olav; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)Background: Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, ... -
Cytosolic phospholipase A2 alpha in aggressive breast cancer: Linking inflammation, angiogenesis, and metastasis
Tunset, Hanna Maja (Doctoral theses at NTNU;2018:340, Doctoral thesis, 2018) -
Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells
Tunset, Hanna Maja; Feuerherm, Astrid Jullumstrø; Selvik, Linn-Karina M.; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with ... -
Detection and differentiation of breast cancer sub-types using a cPLA2a activatable fluorophore
Chiorazzo, MG; Tunset, Hanna Maja; Popov, AV; Johansen, Berit; Moestue, Siver Andreas; Delikatny, EJ (Journal article; Peer reviewed, 2019)Cytosolic phospholipase A2α (cPLA2α) has been shown to be elevated in breast cancer and is a potential biomarker in the differentiation of molecular sub-types. Using a cPLA2α activatable fluorophore, DDAO arachidonate, we ... -
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 ... -
Patterns of Exchange of Multiplying Onion (Allium cepa L. Aggregatum-Group) in Fennoscandian Home Gardens
Leino, Matti W; Solberg, Svein Øivind; Tunset, Hanna Maja; Fogelholm, Jesper; Strese, Else-Marie Karlsson; Hagenblad, Jenny (Journal article; Peer reviewed, 2018)Multiplying onion (Allium cepa L. Aggregatum-Group), commonly known as shallot or potato onion, has a long tradition of cultivation in Fennoscandian home gardens. During the last decades, more than 80 accessions, maintained ...