• Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics 

      Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ...
    • Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity 

      Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ...
    • The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes 

      Roten, Linda Tømmerdal; Thomsen, Liv Cecilie Vestrheim; Gundersen, Astrid; Fenstad, Mona H.; Odland, Maria Lisa; Strand, Kristin Melheim; Solberg, Per; Tappert, Christian; Araya, Elisabeth; Bærheim, Gunhild Marie; Lyslo, Ingvill; Tollaksen, Kjersti; Bjørge, Line; Austgulen, Rigmor (Peer reviewed; Journal article, 2015)
      Background:Preeclampsia is a major pregnancy complication without curative treatment available. A NorwegianPreeclampsia Family Cohort was established to provide a new resource for genetic and molecular studies aiming ...
    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal ...
    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals ...
    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to ...
    • Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts 

      Stødle, Guro; Silva, Gabriela; Tangerås, Line Haugstad; Gierman, Lobke; Nervik, Ingunn; Dahlberg, Unn; Sun, Chen; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2018)
      Pre‐eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger‐sensing pattern recognition receptors (PRRs). Crystalline cholesterol and uric acid activate the PRR ...
    • Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort 

      Thomsen, Liv Cecilie Vestrheim; Melton, Philip E.; Tollaksen, Kjersti; Lyslo, Ingvill; Roten, Linda Tømmerdal; Odland, Maria Lisa; Strand, Kristin Melheim; Nygård, Ottar; Sun, Chen; Iversen, Ann-Charlotte; Austgulen, Rigmor; Moses, Eric; Bjørge, Line (Peer reviewed, 2015)
      Objective: Preeclampsia is a complex genetic disease of pregnancy with a heterogenous presentation, unknown cause and potential severe outcomes for both mother and child. Preeclamptic women have increased risk for ...
    • The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia 

      Thomsen, Liv Cecilie Vestrheim; McCarthy, Nina; Melton, Philip E.; Cadby, Gemma; Austgulen, Rigmor; Nygård, Ottar; Johnson, Matthew P; Brennecke, Shaun P.; Moses, Eric K; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2016)
      Objective: Preeclampsia is a complex heterogeneous disease commonly defined by newonset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later ...