Browsing NTNU Open by Author "Svejda, Bernhard"
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Gene Network Inference and Biochemical Assessment Delineates GPCR Pathways and CREB Targets in Small Intestinal Neuroendocrine Neoplasia
Drozdov, Ignat; Svejda, Bernhard; Gustafsson, Björn; Mane, S; Pfragner, Roswitha; Kidd, Mark; Modlin, Irvin M (Journal article; Peer reviewed, 2011)Small intestinal (SI) neuroendocrine tumors (NET) are increasing in incidence, however little is known about their biology. High throughput techniques such as inference of gene regulatory networks from microarray experiments ... -
Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies
Rokstad, Anne Mari; Gustafsson, Björn; Espevik, Terje; Bakke, Ingunn; Pfragner, Roswitha; Svejda, Bernhard; Modlin, Irvin M; Kidd, Mark (Journal article; Peer reviewed, 2012)Basic cancer research is dependent on reliable in vitro and in vivo tumor models. The serotonin (5‐HT) producing small intestinal neuroendocrine tumor cell line KRJ‐1 has been used in in vitro proliferation and secretion ... -
The Stimulatory Adenosine Receptor ADORA2B Regulates Serotonin (5-HT) Synthesis and Release in Oxygen-Depleted EC Cells in Inflammatory Bowel Disease
Damen, Rikard; Haugen, Martin; Svejda, Bernhard; Alaimo, Daniele; Brenna, Øystein; Pfragner, Roswitha; Gustafsson, Björn; Kidd, Mark (Journal article; Peer reviewed, 2013)Objective: We recently demonstrated that hypoxia, a key feature of IBD, increases enterochromaffin (EC) cell 5-HT secretion, which is also physiologically regulated by the ADORA2B mechanoreceptor. Since hypoxia is ...