Browsing NTNU Open by Author "Skulberg, Arne Kristian"
Now showing items 1-13 of 13
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Ambulance-attended opioid overdoses: An examination into overdose locations and the role of a safe injection facility
Madah-Amiri, Desiree; Skulberg, Arne Kristian; Braarud, Anne-Cathrine; Dale, Ola; Heyerdahl, Fridtjof; Lobmaier, Philipp Paul; Clausen, Thomas (Journal article; Peer reviewed, 2018)Background: Although the United States and numerous other countries are amidst an opioid overdose crisis, access to safe injection facilities remains limited. Methods: We used prospective data from ambulance journals in ... -
Characteristics of Opioid Overdoses and Intranasal Pharmacology of Naloxone
Skulberg, Arne Kristian (Doctoral theses at NTNU;2019:84, Doctoral thesis, 2019)Sammendrag Opioider, morfinlignende stoffer, fører til overdoser og dødsfall. I Norge dør rundt 250 mennesker hvert år. Disse dødsfallene kan i prinsippet forebygges. Det er økende fokus på skadereduserende tiltak, for ... -
Inhaled nitric oxide as temporary respiratory stabilization in patients with COVID-19 related respiratory failure (INOCOV): Study protocol for a randomized controlled trial
Hagemo, Jostein Skjalg; Skulberg, Arne Kristian; Rehn, Marius; Valberg, Morten; Pesonen, Maiju; Heimdal, Hans Julius; Heyerdahl, Fridtjof (Peer reviewed; Journal article, 2022)Background In March 2020, WHO announced the COVID-19 a pandemic and a major global public health emergency. Mortality from COVID-19 is rapidly increasing globally, with acute respiratory failure as the predominant cause ... -
Naloksonnesespray – biotilgjengelighet og opptaksmønster i en fase 1-studie
Tylleskär, Ida; Skulberg, Arne Kristian; Nilsen, Turid; Skarra, Sissel; Dale, Ola (Journal article; Peer reviewed, 2019)Kameratredning med nalokson i nesespray kan forebygge dødsfall ved opioidoverdoser. For å få best mulig opptak av nalokson i nesen må sprayen gis med et lavt volum med høy medikamentkonsentrasjon. Målet med studien var å ... -
Naloxone for opioid overdose - Pharmacological aspects and dosing in clinical practice
Tylleskär, Ida Karin (Doctoral theses at NTNU;2020:236, Doctoral thesis, 2020)Dødsfall fra opioidoverdoser er et stort folkehelseproblem og utdeling av nesespray med motgiften nalokson var foreslått som et tiltak for å redde liv. I 2012 fantes det ingen godkjente nesesprayer på markedet. Istedenfor ... -
NTNU intranasal naloxone trial (NINA-1) study protocol for a double-blind, double-dummy, non-inferiority randomised controlled trial comparing intranasal 1.4 mg to intramuscular 0.8 mg naloxone for prehospital use
Skulberg, Arne Kristian; Tylleskär, Ida; Braarud, Anne-Cathrine; Dale, Jostein; Heyerdahl, Fridtjof; Mellesmo, Sindre; Valberg, Morten; Dale, Ola (Peer reviewed; Journal article, 2020)Abstract Introduction Intranasal naloxone is widely used to treat opioid overdoses. The advantage of nasal administration compared to injection lies in its suitability for administration by lay people as it is needless. ... -
Pharmacodynamics and arteriovenous difference of intravenous naloxone in healthy volunteers exposed to remifentanil
Tylleskär, Ida; Skulberg, Arne Kristian; Skarra, Sissel; Nilsen, Turid; Dale, Ola (Journal article; Peer reviewed, 2018)Purpose Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known ... -
The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers
Tylleskär, Ida; Skarra, Sissel; Skulberg, Arne Kristian; Dale, Ola (Journal article; Peer reviewed, 2021)Purpose Remifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature of this observation. Methods We analysed samples from three pharmacokinetic ... -
Pharmacokinetics and -dynamics of intramuscular and intranasal naloxone: an explorative study in healthy volunteers
Skulberg, Arne Kristian; Tylleskär, Ida; Nilsen, Turid; Skarra, Sissel; Salvesen, Øyvind; Sand, Trond; Loftsson, Thorsteinn; Dale, Ola (Journal article; Peer reviewed, 2018)Purpose This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone ... -
Pharmacokinetics of a new, nasal formulation of naloxone
Tylleskär, Ida; Skulberg, Arne Kristian; Nilsen, Turid; Skarra, Sissel; Jansook, Phatsawee; Dale, Ola (Journal article; Peer reviewed, 2017)Purpose Nasal naloxone is wanted for bystander administration in opioid overdose and as a needle-free alternative for emergency medical personnel. Epidemiologic studies have indicated a therapeutic effect of bystander ... -
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose—a randomized controlled trial
Skulberg, Arne Kristian; Åsberg, Anders; Zare, Hasse Khiabani; Røstad, Hilde; Tylleskär, Ida; Dale, Ola (Peer reviewed; Journal article, 2019)Background and aims Intranasal (i.n.) naloxone is an established treatment for opioid overdose. Anyone likely to witness an overdose should have access to the antidote. We aimed to determine whether an i.n. formulation ... -
Prehospital naloxone administration – what influences choice of dose and route of administration?
Tylleskär, Ida; Gjersing, Linn; Bjørnsen, Lars Petter Bache-Wiig; Braarud, Anne-Cathrine; Heyerdahl, Fridtjof; Dale, Ola; Skulberg, Arne Kristian (Peer reviewed; Journal article, 2020)Background Amidst the ongoing opioid crisis there are debates regarding the optimal route of administration and dosages of naloxone. This applies both for lay people administration and emergency medical services, and in ... -
REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel group, clinical multicentre trial
Brede, Jostein Rødseth; Skulberg, Arne Kristian; Rehn, Marius; Thorsen, Kjetil; Klepstad, Pål; Tylleskär, Ida; Farbu, Bjørn; Dale, Jostein; Nordseth, Trond; Wiseth, Rune; Krüger, Andreas Jørstad (Journal article; Peer reviewed, 2021)Background: Survival after out-of-hospital cardiac arrest (OHCA) is poor and dependent on high-quality cardiopulmonary resuscitation. Resuscitative endovascular balloon occlusion of the aorta (REBOA) may be advantageous ...