Blar i NTNU Open på forfatter "Sharma, Kumar"
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Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis
Øvrehus, Marius Altern; Bruheim, Per; Ju, Wenjun; Zelnick, Leila R.; Langlo, Knut Asbjørn Rise; Sharma, Kumar; de Boer, Ian H.; Hallan, Stein (Journal article; Peer reviewed, 2019)Introduction Hypertensive nephrosclerosis is among the leading causes of end-stage renal disease, but its pathophysiology is poorly understood. We wanted to explore early metabolic changes using gene expression and targeted ... -
Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients
Hallan, Stein; Afkarian, Maryam; Zelnick, Leila R.; Kestenbaum, Bryan; Sharma, Shoba; Saito, Rintaro; Darshi, Manjula; Barding, Gregory; Raftery, Daniel; Ju, Wenjun; Kretzler, Matthias; Sharma, Kumar; de Boer, Ian H. (Journal article; Peer reviewed, 2017)Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. ...