Browsing NTNU Open by Author "Sarno, Antonio"

Now showing items 1-20 of 29

    • Accelerated hydrolysis method for producing partially degraded polyester microplastic fiber reference materials 

      Sarno, Antonio; Olafsen, Kjell; Kubowicz, Stephan; Karimov, Fuad; Sait, Shannen; Sørensen, Lisbet; Booth, Andy (Peer reviewed; Journal article, 2020)
      Microplastic fibers (MPFs) from textiles significantly contribute to the microplastic (MP) load in many environmental matrices and have been shown to negatively impact the organisms therein. Most fate and effect studies ...

    • AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature 

      Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål; Kavli, Bodil Merete; Krokan, Hans Einar (Journal article; Peer reviewed, 2014)
      tThe most common mutations in cancer are C to T transitions, but their origin has remained elusive.Recently, mutational signatures of APOBEC-family cytosine deaminases were identified in many com-mon cancers, suggesting ...

    • An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells 

      Sousa, Mirta; Zub, Kamila Anna; Aas, Per Arne; Hanssen-Bauer, Audun; Demirovic, Aida; Sarno, Antonio; Tian, Erming; Liabakk, Nina-Beate; Slupphaug, Geir (Journal article; Peer reviewed, 2013)
      Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 ...

    • Can lipidomics help identifying egg quality in ballan wrasse? 

      Malzahn, Arne; Sarno, Antonio; Hagemann, Andreas; Farkas, Julia; Musialak, Luciana Alves; Kjørsvik, Elin; Hansen, Bjørn Henrik (Peer reviewed; Journal article, 2022)
      Ballan wrasse (Labrus bergylta) is in the limelight of aquaculture research due to the species role as cleaner fish in salmon aquaculture. A major drawback is that the salmon industry still depends on wild caught fish as ...

    • Changes in food quality attributes of Saccharina latissima following pre-treatments, frozen storage and subsequent thawing 

      Stevant, Pierrick Francois Denis; Aachmann, Finn Lillelund; Arlov, Øystein; Nordtvedt, Tom Ståle; Sarno, Antonio; Aarstad, Olav Andreas; Klau, Leesa Jane; Rustad, Turid; Sæther, Maren; Rebours, Celine (Journal article; Peer reviewed, 2024)
      Changes in relevant quality attributes for the food industry were monitored in Saccharina latissima following pre-treatment (PT), freezing and thawing. The evaluation included the monitoring of qualitative indicators (dry ...

    • Degumming of Ballan wrasse (Labrus bergylta) eggs 

      Shabbir, Fahad (Master thesis, 2022)
      Etterspørselen etter berggylt (Labrus bergylta) har økt gjennom årene på grunn av dens effektivitet som rensefisk for å fjerne lakselus (Lepeophtheirus salmonis) fra oppdrettslaks (Salmo salar) i merder. En av utfordringene ...

    • DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients 

      Olsen, Maria Belland; Huse, Camilla; Sousa, Mirta; Murphy, Sarah Louise Mikalsen; Sarno, Antonio; Obermann, Tobias Sebastian; Yang, Kuan; Holter, Jan Cato; Jørgensen, Marthe Jøntvedt; Christensen, Erik Egeland; Wang, Wei; Ji, Ping; Heggelund, Lars; Hoel, Hedda; Dyrhol-Riise, Anne Ma; Gregersen, Ida; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)
      Purpose: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that ...

    • First feed matters: The first diet of larval fish programmes growth, survival, and metabolism of larval ballan wrasse (Labrus bergylta) 

      Malzahn, Arne; Ribicic, Deni; Hansen, Bjørn Henrik; Sarno, Antonio; Kjørsvik, Elin; Aase, Anna Sigrid Nordberg; Alves Musialak, Luciana; Garcia Calvo, Laura; Hagemann, Andreas (Peer reviewed; Journal article, 2022)
      The use of cleaner fish, such as the ballan wrasse (Labrus bergylta), is important for combatting the sea lice problem in salmonid cage farming. Ballan wrasse is the only wrasse species that is cultivated, though only about ...

    • Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren 

      Castaneda Zegarra, Sergio Miguel; Huse, Camilla; Røsand, Øystein; Sarno, Antonio; Xing, Mengtan; Zhang, Qindong; Alirezaylavasani, Amin; Werner, Julia; Ji, Ping; Liabakk, Nina-Beate; Wang, Wei; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)
      Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes, and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological ...

    • Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH 

      Obermann, Tobias; Sakshaug, Teri Shearer; Kanagaraj, Vishnu Vignesh; Abentung, Andreas; Leal de Sousa, Mirta Mittelstedt; Hagen, Lars; Sarno, Antonio; Bjørås, Magnar; Scheffler, Katja (Peer reviewed; Journal article, 2024)
      8-oxo-7,8-dihydroguanine (OG) is one of the most abundant oxidative lesions in the genome and is associated with genome instability. Its mutagenic potential is counteracted by a concerted action of 8-oxoguanine DNA glycosylase ...

    • HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines 

      Iveland, Tobias Solli; Hagen, Lars; Sharma, Animesh; Sousa, Mirta; Sarno, Antonio; Kristian Lied, Wollen; Liabakk, Nina-Beate; Slupphaug, Geir (Peer reviewed; Journal article, 2020)
      Background HDAC inhibitors (HDACi) belong to a new group of chemotherapeutics that are increasingly used in the treatment of lymphocyte-derived malignancies, but their mechanisms of action remain poorly understood. Here ...

    • Impact of seawater temperature and physical-chemical properties on sorption of pharmaceuticals, stimulants, and biocides to marine particles 

      Sørensen, Lisbet; Hovsbakken, Ingrid Alver; Wielogorska, Ewa; Creese, Mari Egeness; Sarno, Antonio; Caban, Magda; Sokolowski, Adam; Øverjordet, Ida Beathe (Peer reviewed; Journal article, 2024)
      Pharmaceuticals, stimulants, and biocides enter the environment via wastewater from urban, domestic, and industrial areas, in addition to sewage, aquaculture and agriculture runoff. While some of these compounds are easily ...

    • Improved determination of genomic uracil content by high performance liquid chromatography-tandem mass spectrometry 

      Sarno, Antonio (Master thesis, 2011)
      Uracil, a nitrogen base usually found in RNA, may be found in small quantities in genomic DNA. Genomic uracil may arise as a result of deamination of cytosine or misincorporation of deoxyuridine monophosphate (dUMP) instead ...

    • Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. 

      Zub, Kamila Anna; Sousa, Mirta; Sarno, Antonio; Sharma, Animesh; Demirovic, Aida; Rao, Shalini; Young, Clifford; Aas, Per Arne; Ericsson, Ida; Sundan, Anders; Jensen, Ole Nørregaard; Slupphaug, Geir (Journal article; Peer reviewed, 2015)
      Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most commonly used chemotherapeutic ...

    • MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP 

      Jemth, Ann-Sofie; Gustafsson, Robert; Bräutigam, Lars; Henriksson, Linda; Vallin, Karl S.A.; Sarno, Antonio; Almlöf, Ingrid; Homan, Evert; Rasti, Azita; Warpman Berglund, Ulrika; Stenmark, Pål; Helleday, Thomas (Journal article; Peer reviewed, 2018)
      Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. ...

    • MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool 

      Scaletti, Emma Rose; Vallin, Karl S.A.; Bräutigam, Lars; Sarno, Antonio; Berglund, Ulrika Warpman; Helleday, Thomas; Stenmark, Pål; Jemth, Ann-Sofie (Peer reviewed; Journal article, 2020)
      MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient ...

    • Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF 

      Gago-Fuentes, Raquel; Xing, Mengtan; Sæterstad, Siri; Sarno, Antonio; Dewan, Alisa Elinsdatter; Beck, Carole; Bradamante, Stefano; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)
      DNA repair consists of several cellular pathways which recognize and repair damaged DNA. The classical nonhomologous DNA end-joining (NHEJ) pathway repairs double-strand breaks in DNA. It is required for maturation of both ...

    • Ova lipid profiling and egg quality in wild and captive lumpfish, Cyclopterus lumpus (Linnaeus, 1758) 

      Hansen, Bjørn Henrik; Kjørsvik, Elin; Malzahn, Arne; Sarno, Antonio; Kulild, Ole Martin; Farkas, Julia; Nordtug, Trond; Rye, Rebecca; Kvæstad, Bjarne; Lein, Ingrid; Hagemann, Andreas (Peer reviewed; Journal article, 2022)
      Lumpfish (Cyclopterus lumpus) serves an important role as cleaner fish for removing salmon lice in salmon aquaculture. For this use, cultivated lumpfish are preferred over wild-caught fish to avoid overexploitation of ...

    • RNA metabolism guided by RNA modifications: The role of SMUG1 in rRNA quality control 

      Lirussi, Lisa; Demir, Özlem; You, Panpan; Sarno, Antonio; Amaro, Rommie E.; Nilsen, Hilde (Peer reviewed; Journal article, 2021)
      RNA modifications are essential for proper RNA processing, quality control, and maturation steps. In the last decade, some eukaryotic DNA repair enzymes have been shown to have an ability to recognize and process modified ...

    • RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork 

      Hayran , Abdul Baset ; Liabakk, Nina-Beate; Aas, Per Arne; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Sarno, Antonio; Iveland, Tobias Solli; Chawla, Konika; Zahn, Astrid; DiNoia, Javier M; Slupphaug, Geir; Kavli, Bodil Merete (Peer reviewed; Journal article, 2023)
      Activation-induced cytidine deaminase (AID) interacts with replication protein A (RPA), the major ssDNA-binding protein, to promote deamination of cytosine to uracil in transcribed immunoglobulin (Ig) genes. Uracil-DNA ...