Blar i NTNU Open på forfatter "Sandvig, Axel"
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Analysis of Codman microcerebrospinal fluid shunt
Sandvig, Axel; Arnell, Kai; Malm, Jan; Eklund, Anders; Koskinen, Lars-Owe (Journal article; Peer reviewed, 2018)Introduction Ventriculo‐peritoneal cerebrospinal fluid (CSF) shunt is the most common method of treating pediatric hydrocephalus. The Codman microadjustable valve (CMAV) is a CSF shunt constructed for children. The objective ... -
Assessment and manipulation of the computational capacity of in vitro neuronal networks through criticality in neuronal avalanches
Heiney, Kristine; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (Chapter, 2020)In this work, we report the preliminary analysis of the electrophysiological behavior of in vitro neuronal networks to identify when the networks are in a critical state based on the size distribution of network-wide ... -
Bridging the gap between fluid biomarkers for Alzheimer’s disease, model systems, and patients
Bjorkli, Christiana; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2020)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of intensive research, we cannot yet pinpoint ... -
Combinatory strategies for promoting tissue remodelling and endogenous plasticity after experimental ischemic stroke
Augestad, Ingrid Lovise (Doctoral theses at NTNU;2018:145, Doctoral thesis, 2018)Ulike strategier for å fremme regenerering og endogen plastisitet i hjernen etter eksperimentelt iskemisk slag Hjerneslag er på verdensbasis en av sykdommene som rammer flest mennesker i tillegg til å ha høy dødelighet. ... -
Connectomics of morphogenetically engineered neurons as a predictor of functional integration in the ischemic brain
Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2019)Recent advances in cell reprogramming technologies enable the in vitro generation of theoretically unlimited numbers of cells, including cells of neural lineage and specific neuronal subtypes from human, including ... -
Controlling the self-assembly and optical properties of gold nanoclusters and gold nanoparticles biomineralized with bovine serum albumin
McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Bandyopadhyay, Sulalit; Lystvet, Sina Maria; Ryan, Joseph Anthony; Volden, Sondre; Kim, Eugene; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2015)While the size-dependent optical properties of BSA-stabilized gold nanoclusters are well known, the time-dependent growth mechanism remains to be described. Herein, we systematically compare two synthesis methods with and ... -
Criticality as a measure of developing proteinopathy in engineered human neural networks
Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Journal article, 2020)A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of alpha-synuclein proteins aggregate and accumulate in hallmark ... -
Criticality, Connectivity, and Neural Disorder: A Multifaceted Approach to Neural Computation
Heiney, Kristine; Huse Ramstad, Ola; Fiskum, Vegard; Christiansen, Nicholas; Sandvig, Axel; Nichele, Stefano; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)It has been hypothesized that the brain optimizes its capacity for computation by self-organizing to a critical point. The dynamical state of criticality is achieved by striking a balance such that activity can effectively ... -
Development of a tailored microfluidic platform with improved electrical signal detection for in vitro studies of neural networks and neural network pathology
Winter-Hjelm, Nicolai (Master thesis, 2020)Menneskets nervesystem utgjør verdens mest avanserte evolusjonære maskineri. Gjennom dets høyst intrikate arkitektur og beregningsevner kontrollerer det oppgaver så funksjonelt forskjellige som muskelbevegelser og lagring ... -
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks
Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of α-synuclein proteins accumulate in hallmark pathological inclusions ... -
Effects of neural stem cell and olfactory ensheathing cell co-transplants on tissue remodelling after transient focal cerebral ischemia in the adult rat
Augestad, Ingrid Lovise; Nyman, Axel Karl Gottfrid; Costa, Alex Ignatius; Barnett, Susan Carol; Sandvig, Axel; Håberg, Asta; Sandvig, Ioanna (Journal article; Peer reviewed, 2017)Effective transplant-mediated repair of ischemic brain lesions entails extensive tissue remodeling, especially in the ischemic core. Neural stem cells (NSCs) are promising reparative candidates for stroke induced lesions, ... -
Epigenetic modulation of stem cells in neurodevelopment: The role of methylation and acetylation
Podobinska, Martyna; Szablowska-Gadomska, Ilona; Augustyniak, Justyna; Sandvig, Ioanna; Sandvig, Axel; Buzanska, Leonora (Journal article; Peer reviewed, 2017)The coordinated development of the nervous system requires fidelity in the expression of specific genes determining the different neural cell phenotypes. Stem cell fate decisions during neurodevelopment are strictly ... -
Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles
Valderhaug, Vibeke Devold; Glomm, Wilhelm; Sandru, Eugenia Mariana; Yasuda, Masahiro; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2019)In vitro electrophysiological investigation of neural activity at a network level holds tremendous potential for elucidating underlying features of brain function (and dysfunction). In standard neural network modelling ... -
Generating Neural Networks from Ependymal Cells harvested after Spinal Cord Injury
Rem, Marit Trones (Master thesis, 2020)Traumatisk ryggmargsskader (tRMS) er preget av alvorlige, irreversible forstyrrelser av lokale og nevrale kretsløp i ryggmargen med ødeleggende effekt som når gjennom de supraspinale kanalene. Som svar på tRMS, blir ... -
Growing gold nanostructures for shape-selective cellular uptake
Bandyopadhyay, Sulalit; McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Raghunathan, Karthik; Sandvig, Axel; Sandvig, Ioanna; Andreassen, Jens-Petter; Glomm, Wilhelm (Journal article; Peer reviewed, 2018)With development in the synthesis of shape- and size-dependent gold (Au) nanostructures (NSs) and their applications in nanomedicine, one of the biggest challenges is to understand the interaction of these shapes with ... -
Hallmarks of Criticality in Neuronal Networks Depend on Cell Type and the Temporal Resolution of Neuronal Avalanches
Heiney, Kristine; Valderhaug, Vibeke Devold; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (Peer reviewed; Journal article, 2021)The human brain has a remarkable capacity for computation, and it has been theorized that this capacity arises from the brain self-organizing into the critical state, a dynamical state poised between ordered and dis- ordered ... -
How does ALS pathology spread to affect healthy neurons? Recapitulation of disease progression in multi-nodal neural networks in vitro
Kollstrøm, Anna Mikalsen (Master thesis, 2020)Amyotrofisk lateral sklerose (ALS) er en nevrodegenerativ sykdom som påvirker øvre og nedre motornevroner, hvilket fører til en gradvis lammelse av muskler og som til slutt resulterer i død på grunn av respirasjonssvikt. ... -
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology
Bjorkli, Christiana; Louet, Claire; Flo, Trude Helen; Hemler, Mary Elizabeth; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)Background: Preclinical models of Alzheimer’s disease (AD) can provide valuable insights into the onset and progression of the disease, such as changes in concentrations of amyloid-β (Aβ) and tau in cerebrospinal fluid ... -
Inhibiting the neuronal region with initial neurodegeneration: effects on neuropathology and behavior
Ebbesen, Nora Cecilie (Master thesis, 2021)Alzheimers sykdom er nevrodegenerativ og progressiv, og den vanligste årsaken til demens. Til tross for at Alzheimers er en økende global helse- og sosioøkonomisk bekymring, er ingen effektiv kur eller behandling tilgjengelig. ... -
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles
McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Peddis, Davide; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2016)Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active ...