Browsing NTNU Open by Author "Sandvig, Axel"
Now showing items 1-20 of 27
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Analysis of Codman microcerebrospinal fluid shunt
Sandvig, Axel; Arnell, Kai; Malm, Jan; Eklund, Anders; Koskinen, Lars-Owe (Journal article; Peer reviewed, 2018)Introduction Ventriculo‐peritoneal cerebrospinal fluid (CSF) shunt is the most common method of treating pediatric hydrocephalus. The Codman microadjustable valve (CMAV) is a CSF shunt constructed for children. The objective ... -
Assessment and manipulation of the computational capacity of in vitro neuronal networks through criticality in neuronal avalanches
Heiney, Kristine; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (Chapter, 2020)In this work, we report the preliminary analysis of the electrophysiological behavior of in vitro neuronal networks to identify when the networks are in a critical state based on the size distribution of network-wide ... -
Bridging the gap between fluid biomarkers for Alzheimer’s disease, model systems, and patients
Bjorkli, Christiana; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2020)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of intensive research, we cannot yet pinpoint ... -
Combinatory strategies for promoting tissue remodelling and endogenous plasticity after experimental ischemic stroke
Augestad, Ingrid Lovise (Doctoral theses at NTNU;2018:145, Doctoral thesis, 2018)Ulike strategier for å fremme regenerering og endogen plastisitet i hjernen etter eksperimentelt iskemisk slag Hjerneslag er på verdensbasis en av sykdommene som rammer flest mennesker i tillegg til å ha høy dødelighet. ... -
Connectomics of morphogenetically engineered neurons as a predictor of functional integration in the ischemic brain
Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2019)Recent advances in cell reprogramming technologies enable the in vitro generation of theoretically unlimited numbers of cells, including cells of neural lineage and specific neuronal subtypes from human, including ... -
Controlling the self-assembly and optical properties of gold nanoclusters and gold nanoparticles biomineralized with bovine serum albumin
McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Bandyopadhyay, Sulalit; Lystvet, Sina Maria; Ryan, Joseph Anthony; Volden, Sondre; Kim, Eugene; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2015)While the size-dependent optical properties of BSA-stabilized gold nanoclusters are well known, the time-dependent growth mechanism remains to be described. Herein, we systematically compare two synthesis methods with and ... -
Criticality as a measure of developing proteinopathy in engineered human neural networks
Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Journal article, 2020)A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of alpha-synuclein proteins aggregate and accumulate in hallmark ... -
Criticality, Connectivity, and Neural Disorder: A Multifaceted Approach to Neural Computation
Heiney, Kristine; Huse Ramstad, Ola; Fiskum, Vegard; Christiansen, Nicholas; Sandvig, Axel; Nichele, Stefano; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)It has been hypothesized that the brain optimizes its capacity for computation by self-organizing to a critical point. The dynamical state of criticality is achieved by striking a balance such that activity can effectively ... -
Effects of neural stem cell and olfactory ensheathing cell co-transplants on tissue remodelling after transient focal cerebral ischemia in the adult rat
Augestad, Ingrid Lovise; Nyman, Axel Karl Gottfrid; Costa, Alex Ignatius; Barnett, Susan Carol; Sandvig, Axel; Håberg, Asta; Sandvig, Ioanna (Journal article; Peer reviewed, 2017)Effective transplant-mediated repair of ischemic brain lesions entails extensive tissue remodeling, especially in the ischemic core. Neural stem cells (NSCs) are promising reparative candidates for stroke induced lesions, ... -
Epigenetic modulation of stem cells in neurodevelopment: The role of methylation and acetylation
Podobinska, Martyna; Szablowska-Gadomska, Ilona; Augustyniak, Justyna; Sandvig, Ioanna; Sandvig, Axel; Buzanska, Leonora (Journal article; Peer reviewed, 2017)The coordinated development of the nervous system requires fidelity in the expression of specific genes determining the different neural cell phenotypes. Stem cell fate decisions during neurodevelopment are strictly ... -
Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles
Valderhaug, Vibeke Devold; Glomm, Wilhelm; Sandru, Eugenia Mariana; Yasuda, Masahiro; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2019)In vitro electrophysiological investigation of neural activity at a network level holds tremendous potential for elucidating underlying features of brain function (and dysfunction). In standard neural network modelling ... -
Growing gold nanostructures for shape-selective cellular uptake
Bandyopadhyay, Sulalit; McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Raghunathan, Karthik; Sandvig, Axel; Sandvig, Ioanna; Andreassen, Jens-Petter; Glomm, Wilhelm (Journal article; Peer reviewed, 2018)With development in the synthesis of shape- and size-dependent gold (Au) nanostructures (NSs) and their applications in nanomedicine, one of the biggest challenges is to understand the interaction of these shapes with ... -
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles
McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Peddis, Davide; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2016)Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active ... -
Labelling of olfactory ensheathing cells with micron-sized particles of iron oxide and detection by MRI
Sandvig, Ioanna; Hoang, Linh; Sardella, Thomas CP; Barnett, SC; Brekken, Christian; Tvedt, Kåre; Berry, Martin; Haraldseth, Olav; Sandvig, Axel; Thuen, Marte (Journal article; Peer reviewed, 2012)A crucial issue in transplant‐mediated repair of the damaged central nervous system (CNS) is serial non‐invasive imaging of the transplanted cells, which has led to interest in the application of magnetic resonance imaging ... -
Method to Obtain Neuromorphic Reservoir Networks from Images of in Vitro Cortical Networks
Mello, Gustavo; Pontes-Filho, Sidney; Sandvig, Ioanna; Valderhaug, Vibeke Devold; Zouganeli, Evi; Huse Ramstad, Ola; Sandvig, Axel; Nichele, Stefano (Chapter, 2020)In the brain, the structure of a network of neurons defines how these neurons implement the computations that underlie the mind and the behavior of animals and humans. Provided that we can describe the network of neurons ... -
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles
Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ... -
Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach
Malmo, Jostein; Sandvig, Axel; Vårum, Kjell Morten; Strand, Sabina P. (Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Neural disorder at the edge of chaos
Ramstad, Ola Huse (Doctoral theses at NTNU;2020:288, Doctoral thesis, 2020) -
Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks
Sandvig, Ioanna; Augestad, Ingrid Lovise; Håberg, Asta; Sandvig, Axel (Journal article; Peer reviewed, 2018)Neuroplasticity after ischaemic injury involves both spontaneous rewiring of neural networks and circuits as well as functional responses in neurogenic niches. These events involve complex interactions with activated ... -
Smart and Multifunctional Core-Shell Nanoparticles (NPs) for Drug Delivery
Bandyopadhyay, Sulalit (Doctoral theses at NTNU;2016:294, Doctoral thesis, 2016)Nanomaterials designed for drug delivery applications require important properties that include monodispersity, biocompatibility, long circulation time which are dependent on size, shape, composition, surface charge among ...