• Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer's disease, mild cognitive impairment, or healthy controls: a two year follow-up study 

      Sando, Sigrid Botne; Albrektsen, Grethe; Møller, Ina; White, Linda; Berge, Guro; Grøntvedt, Gøril Rolfseng; Lauridsen, Camilla; Bråthen, Geir (Journal article; Peer reviewed, 2016)
      Background α-Synuclein has been proposed as a potential biomarker for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). However, results from α-synuclein measurements in cerebrospinal fluid (CSF) ...
    • Alzheimer’s disease in central Norway: Genetic and educational aspects 

      Sando, Sigrid Botne (Doktoravhandlinger ved NTNU, 1503-8181; 2008:135, Doctoral thesis, 2008)
    • Amyloid beta 1-43 as a potential biomarker for the detection of early Alzheimer’s disease 

      Lauridsen, Camilla (Doctoral theses at NTNU;2017:219, Doctoral thesis, 2017)
    • APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway 

      Sando, Sigrid Botne; Melquist, Stacey; Cannon, Ashley; Hutton, Michael; Sletvold, Olav; Saltvedt, Ingvild; White, Linda; Lydersen, Stian; Aasly, Jan (Journal article; Peer reviewed, 2008)
      Background: The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. The APOE ε4 allele is the only consistently identified risk factor for late ...
    • Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease 

      Patra, Kalicharan; Soosaipillai, Antoninus; Sando, Sigrid Botne; Lauridsen, Camilla; Berge, Guro; Møller, Ina; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; Begcevic, Ilijana; Moussaud, Simon; Minthon, Lennart; Hansson, Oskar; Diamandis, Eleftherios P.; White, Linda Rosemary; Nielsen, Henrietta M. (Journal article; Peer reviewed, 2018)
      Background Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in ...
    • Cerebrospinal fluid A?43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to A?42 

      Lauridsen, Camilla; Sando, Sigrid Botne; Møller, Ina; Berge, Guro; Pomary, Precious Kwadzo; Grøntvedt, Gøril Rolfseng; Salvesen, Øyvind; Bråthen, Geir; White, Linda (Journal article; Peer reviewed, 2017)
      Background: Amyloid beta 1–43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer’s disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast ...
    • Cerebrospinal Fluid Levels of Amyloid Beta 1-43 in Patients with Amnestic Mild Cognitive Impairment or Early Alzheimer's Disease: A 2-Year Follow-Up Study 

      Lauridsen, Camilla; Sando, Sigrid Botne; Shabnam, Adiba; Møller, Ina; Berge, Guro; Grøntvedt, Gøril Rolfseng; Bakken, Inger Johanne; Salvesen, Øyvind; Bråthen, Geir; White, Linda (Journal article; Peer reviewed, 2016)
      Introduction: Biomarkers that will reliably predict the onset of Alzheimer’s disease (AD) are urgently needed. Although cerebrospinal fluid (CSF) amyloid beta 1–42 (Aβ42), total tau, and phosphorylated tau can be used to ...
    • Cerebrospinal fluid levels of amyloid beta 1-43 mirror 1-42 in relation to imaging biomarkers of Alzheimer's disease 

      Almdahl, Ina; Lauridsen, Camilla; Selnes, Per; Kalheim, Lisa Flem; Coello, Christopher; Gajdzik, Beata; Møller, Ina; Wettergreen, Marianne; Grambaite, Ramune; Bjørnerud, Atle; Bråthen, Geir; Sando, Sigrid Botne; White, Linda; Fladby, Tormod (Journal article; Peer reviewed, 2017)
    • Cognitive and Emotional Impairment after Minor Stroke and Non-ST-Elevation Myocardial Infarction (NSTEMI): A Prevalence Study 

      Morsund, Åse Hagen; Ellekjær, Hanne; Gramstad, Arne; Reiestad, Magnus Tallaksen; Midgard, Rune; Sando, Sigrid Botne; Jonsbu, Egil; Næss, Halvor (Journal article; Peer reviewed, 2019)
      Aim. To study the prevalence of cognitive and emotional impairment following a minor ischemic stroke compared to an age-matched group with non-ST-elevation myocardial infarction (NSTEMI). Methods. We included patients aged ...
    • Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years 

      Kirsebom, Bjørn-Eivind; Espenes, Ragna; Hessen, Erik; Waterloo, Knut; Johnsen, Stein Harald; Gundersen, Elisabeth; Sando, Sigrid Botne; Grøntvedt, Gøril Rolfseng; Timón, Santiago; Fladby, Tormod (Journal article; Peer reviewed, 2019)
      Background/Objective: In recent years, several slightly younger cohorts have been established in order to study the preclinical and prodromal phases of dementia. The Consortium to Establish a Registry for Alzheimer’s Disease ...
    • GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study 

      Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2019)
      Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ...
    • Kartlegging av kognitiv funksjon hos pasienter som har gjennomgått bariatrisk kirurgi 

      Bjøru, Hege Tevik (Master thesis, 2017)
      Bakgrunn: Studier viser både at fedme kan påvirke kognitiv funksjon negativt og at kognitiv funksjon bedres etter bariatrisk kirurgi. Imidlertid rapporterer fedmeopererte pasienter ved St. Olavs Hospital ikke sjelden ...
    • LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer's Disease (LOAD) 

      Lincoln, Sarah; Allen, Mariet; Cox, Claire L.; Walker, Louise P.; Malphrus, Kimberly; Qiu, Yishu; Nguyen, Thuy; Rowley, Christopher; Kouri, Naomi; Crook, Julia; Pankratz, V. Shane; Younkin, Samuel; Younkin, Linda; Carrasquillo, Minerva; Zou, Fang Geng; Abdul-Hay, Samer O.; Springer, Wolfdieter; Sando, Sigrid Botne; Aasly, Jan; Barcikowska, Maria; Wszolek, Zbigniew K.; Lewis, Jada M.; Dickson, Dennis; Graff-Radford, Neil R.; Petersen, Ronald C.; Eckman, Elizabeth; Younkin, Steven G.; Ertekin-Taner, Nilüfer (Journal article; Peer reviewed, 2013)
      Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3) and resides at the linkage peak for late-onset Alzheimer’s disease (LOAD) ...
    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2018)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...
    • Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease 

      Desikan, Rahul S.; Schork, Andrew J.; Wang, Yunpeng; Thompson, Wesley K.; Dehghan, Abbas; Ridker, Paul M.; Chasman, Daniel I.; McEvoy, Linda K.; Holland, Dominic; Chen, Chi-Hua; Karow, David S.; Brewer, James B.; Hess, Christopher P.; Williams, Julie; Sims, Rebecca; O'Donovan, Michael C.; Choi, Seung Hoan; Bis, Joshua C.; Ikram, M. Arfan; Gudnason, Vilmundur; DeStefano, Anita L.; Van Der Lee, Sven J.; Psaty, Bruce M.; Van Duijn, Cornelia M.; Launer, Lenore; Seshadri, Sudha; Pericak-Vance, Margaret A.; Mayeux, Richard; Haines, Jonathan L.; Farrer, Lindsay A.; Hardy, John; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; White, Linda; Sando, Sigrid Botne; Rongve, Arvid; Witoelar, Aree; Djurovic, Srdjan; Hyman, Bradley T.; Snædal, Jon; Steinberg, Stacy; Stefansson, Hreinn; Stefánsson, Kári; Schellenberg, Gerard D.; Andreassen, Ole Andreas; Dale, Anders (Journal article; Peer reviewed, 2015)
      Background—Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this ...
    • Proteins associated with core biomarkers in early Alzheimer`s disease: A pilot study of levels in cerebrospinal fluid, serum or plasma 

      Medbøen, Ingrid Tøndel (Master thesis, 2014)
      Background:The cerebrospinal fluid (CSF) biomarkers amyloid-beta 42 (Aβ42), total tau (T-tau) and phosphorylated tau (P-tau) are considered to reflect core pathological features of Alzheimer’s disease (AD), and have ...
    • The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease 

      Twohig, Daniel; Rodriguez-Vieitez, Elena; Sando, Sigrid Botne; Berge, Guro; Lauridsen, Camilla; Møller, Ina; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; Patra, Kalicharan; Bu, Guojun; Benzinger, Tammie; Karch, Celeste M.; Fagan, Anne M.; Morris, John C.; Bateman, Randall J.; Nordberg, Agneta; White, Linda Rosemary; Nielsen, Henrietta M. (Journal article; Peer reviewed, 2018)
      Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer’s disease (AD) patients suggests that αSyn is involved in the pathophysiology of ...
    • Vurdering av biokjemiske og nevropsykologiske parametre hos friske eldre 

      Sagberg, Ingunn (Master thesis, 2012)
      Bakgrunn: I takt med at levealderen i befolkningen øker, vil en økende andel utvikle Alzheimers sykdom (AD), etter som alder er den viktigste risikofaktoren for AD. Når effektiv behandling blir tilgjengelig, blir det viktig ...