• Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway 

      Langballe, Ellen Melbye; Ask, Helga; Holmen, Jostein; Stordal, Eystein; Saltvedt, Ingvild; Selbæk, Geir; Fikseaunet, Arvid; Bergh, Sverre; Nafstad, Per; Tambs, Kristian (Journal article; Peer reviewed, 2015)
      The relationship between alcohol consumption and dementia risk is unclear. This investigation estimates the association between alcohol consumption reported in a population-based study in the mid-1980s and the risk for ...
    • Alzheimer's Disease - The Impact of Vascular Comorbidity on Disease Progression and Clinical Profile 

      Eldholm, Rannveig Sakshaug (Doctoral theses at NTNU;2019:77, Doctoral thesis, 2019)
    • APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway 

      Sando, Sigrid Botne; Melquist, Stacey; Cannon, Ashley; Hutton, Michael; Sletvold, Olav; Saltvedt, Ingvild; White, Linda; Lydersen, Stian; Aasly, Jan (Journal article; Peer reviewed, 2008)
      Background: The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. The APOE ε4 allele is the only consistently identified risk factor for late ...
    • Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study 

      Gabin, Jessica Mira; Tambs, Kristian; Saltvedt, Ingvild; Sund, Erik; Holmen, Jostein (Journal article; Peer reviewed, 2017)
      Background A lot of attention has been paid to the relationship of blood pressure and dementia because epidemiological research has reported conflicting evidence. Observational data has shown that midlife hypertension is ...
    • Association between vascular comorbidity and progression of Alzheimer's disease: a two-year observational study in Norwegian memory clinics 

      Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Barca, Maria Lage; Knapskog, Anne Brita; Cavallin, Lena; Engedal, Knut; Skovlund, Eva; Saltvedt, Ingvild; Selbaek, Geir (Journal article; Peer reviewed, 2018)
      Background: Vascular risk factors increase the risk of Alzheimer’s disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of this ...
    • Cortisol levels among older people with and without depression and dementia 

      Barca, Maria Lage; Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Björklöf, Guro Hanevold; Borza, Tom; Telenius, Elisabeth Wiken; Knapskog, Anne-Brita; Brækhus, Anne; Saltvedt, Ingvild; Selbæk, Geir; Engedal, Knut (Journal article; Peer reviewed, 2018)
      Cortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample of 650 ...
    • Delirium motor subtypes and prognosis in hospitalized geriatric patients – A prospective observational study 

      Evensen, Sigurd; Saltvedt, Ingvild; Lydersen, Stian; Wyller, Torgeir Bruun; Taraldsen, Kristin; Sletvold, Olav (Journal article; Peer reviewed, 2019)
      Objective Delirium is common and associated with poor outcomes. Hypoactive motor subtype may predict worse outcome than no-subtype, hyperactive and mixed delirium, but uncertainty remains due to heterogeneity of results ...
    • Delirium og kognitiv svikt blant eldre i norske akuttmottak 

      Evensen, Sigurd; Saltvedt, Ingvild; Ranhoff, Anette Hylen; Myrstad, Marius; Myrstad, Christian; Mellingsæter, Marte; Wang-Hansen, Marte Sofie; Neerland, Bjørn Erik (Journal article; Peer reviewed, 2019)
      BAKGRUNN Delirium er vanlig og underdiagnostisert blant pasienter på sykehus og er assosiert med komplikasjoner, økt dødelighet, demensutvikling og behov for sykehjemsplass. Kognitiv svikt av andre årsaker er også vanlig ...
    • Development and delivery of patient treatment in the Trondheim Hip Fracture Trial. A new geriatric in-hospital pathway for elderly patients with hip fracture 

      Saltvedt, Ingvild; Prestmo, Anders; Einarsen, Elin Kristin; Johnsen, Lars Gunnar; Helbostad, Jorunn L.; Sletvold, Olav (Journal article; Peer reviewed, 2012)
      Background Hip fractures are common among frail elderly persons and often have serious consequences on function, mobility and mortality. Traditional treatment of these patients is performed in orthopedic departments without ...
    • Drug prescription patterns in elderly hip fracture patients at admission and discharge from hospital: A substudy of the Trondheim Hip Fracture Trial - a randomized controlled trial 

      Heltne, Marianne (Master thesis, 2013)
      Background: Hip fractures in the elderly are common, and may have serious consequences. Drug use might be contributing to the falls and subsequent fractures, and might be of significance as an intervention target. The ...
    • Effect of in-hospital comprehensive geriatric assessment (CGA) in older people with hip fracture. The protocol of the Trondheim Hip Fracture Trial 

      Sletvold, Olav; Helbostad, Jorunn L.; Thingstad, Pernille; Taraldsen, Kristin; Prestmo, Anders; Lamb, SE; Aamodt, Arild; Johnsen, Roar; Magnussen, Jon; Saltvedt, Ingvild (Journal article; Peer reviewed, 2011)
      Background Hip fractures in older people are associated with high morbidity, mortality, disability and reduction in quality of life. Traditionally people with hip fracture are cared for in orthopaedic departments without ...
    • Environmental factors and risk of delirium in geriatric patients: An observational study 

      Evensen, Sigurd; Saltvedt, Ingvild; Lydersen, Stian; Wyller, Torgeir Bruun; Taraldsen, Kristin; Sletvold, Olav (Journal article; Peer reviewed, 2018)
      Background Patients with delirium have increased risk of death, dementia and institutionalization, and prognosis differs between delirium motor subtypes. A few studies have identified associations between environmental ...
    • Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease 

      Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive; Selbæk, Geir (Journal article; Peer reviewed, 2019)
      Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ...
    • Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients 

      Knapskog, Anne Brita; Eldholm, Rannveig Sakshaug; Brækhus, Anne; Engedal, Knut; Saltvedt, Ingvild (Journal article; Peer reviewed, 2017)
      Background The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ), phospho tau (P-tau) and total tau (T-tau) are used increasingly to support a clinical diagnosis of Alzheimer’s disease. The diagnostic power of these ...
    • GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study 

      Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2019)
      Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ...
    • Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk 

      Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas; Posthuma, Danielle (Journal article; Peer reviewed, 2019)
      Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ...
    • Interdisciplinary care of hip fractures: Orthogeriatric models, alternative models, interdisciplinary teamwork 

      Ranhoff, Anette Hylen; Saltvedt, Ingvild; Frihagen, Frede Jon; Ræder, Johan; Maini, Sameer; Sletvold, Olav (Journal article; Peer reviewed, 2019)
      Hip fractures are common among older people, and the prognosis is serious in terms of mobility, independence in daily life activities, and cognition, with 42% of patients never achieving the same function as before the ...
    • The long-term effect of being treated in a geriatric ward compared to an orthopaedic ward on six measures of free-living physical behavior 4 and 12 months after a hip fracture – a randomised controlled trial. 

      Taraldsen, Kristin; Thingstad, Pernille; Sletvold, Olav; Saltvedt, Ingvild; Lydersen, Stian; Granat, Malcolm H.; Chastin, Sebastien; Helbostad, Jorunn L. (Peer reviewed; Journal article, 2015)
      Background This study is part of the Trondheim Hip Fracture Trial, where we compared free-living physical behavior in daily life 4 and 12 months following hip surgery for patients managed with comprehensive geriatric ...
    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2018)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...