• Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits 

      Nayor, Matthew; Short, Meghan I.; Rasheed, Humaira; Lin, Honghuang; Jonasson, Christian; Yang, Qiong; Hveem, Kristian; Felix, Janine F.; Morrison, Alanna C.; Wild, Philipp S.; Morley, Michael P.; Cappola, Thomas P.; Benson, Mark D.; Ngo, Debby; Sinha, Sumita; Keyes, Michelle J.; Shen, Dongxiao; Wang, Thomas J.; Larson, Martin G.; Brumpton, Ben Michael; Gerszten, Robert E.; Omland, Torbjørn; Vasan, Ramachandran S. (Peer reviewed; Journal article, 2020)
      Abstract Background: We used a large-scale, high-throughput DNA aptamer-based discovery proteomic platform to identify circulating biomarkers of cardiac remodeling and incident heart failure (HF) in community-dwelling ...
    • Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals 

      Stanzick, Kira J.; Li, Yong; Schlosser, Pascal; Gorski, Mathias; Wuttke, Matthias; Thomas, Laurent F.; Rasheed, Humaira; Rowan, Bryce X.; Graham, Sarah E.; Vanderweff, Brett R.; Patil, Snehal B.; Robinson-Cohen, Cassiane; Gaziano, John M.; O’Donnell, Christopher J.; Willer, Cristen J.; Hallan, Stein; Åsvold, Bjørn Olav; Gessner, Andre; Hung, Adriana M.; Pattaro, Cristian; Köttgen, Anna; Stark, Klaus; Heid, Iris M.; Winkler, Thomas W. (Journal article; Peer reviewed, 2021)
      Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for ...
    • Genome-wide association study of cardiac troponin i in the general population 

      Moksnes, Marta Riise; Røsjø, Helge; Richmond, Anne; Lyngbakken, Magnus N; Graham, Sarah E; Wolford, Brooke N; Hansen, Ailin Falkmo; Gagliano Taliun, Sarah A; Lefaive, Jonathon; Rasheed, Humaira; Thomas, Laurent; Zhou, Wei; Aung, Nay; Surakka, Ida; Douville, Nicholas J; Campbell, Archie; Porteous, David J; Petersen, Steffen E; Munroe, Patricia B; Welsh, Paul; Sattar, Naveed; Smith, George Davey; Fritsche, Lars G; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Hveem, Kristian; Hayward, Caroline; Willer, Cristen J; Brumpton, Ben M; Omland, Torbjørn (Peer reviewed; Journal article, 2021)
      Circulating cardiac troponin proteins are associated with structural heart disease and predict incident cardiovascular disease in the general population. However, the genetic contribution to cardiac troponin I (cTnI) ...
    • GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer 

      Zhou, Wei; Brumpton, Ben Michael; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Joshua; Zawistowski, Matthew; Nielsen, Jonas Bille; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne R.; Karjalainen, Juha; Kurki, Mitja I.; Oneka, Morgan; Taylor, Peter; Fritsche, Lars; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Bordal, Eirin Haug; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana; Mayordomo, Jose; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark J.; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2020)
      Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to ...
    • Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations 

      Flatby, Helene Marie; Rasheed, Humaira; Ravi, Anuradha; Thomas, Laurent; Liyanarachi, Kristin Vardheim; Afset, Jan Egil; DeWan, Andrew; Brumpton, Ben Michael; Hveem, Kristian; Åsvold, Bjørn Olav; Simonsen, Gunnar Skov; Furberg, Anne-Sofie; Damås, Jan Kristian; Solligård, Erik; Rogne, Tormod (Journal article; Peer reviewed, 2021)
      Objective: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality worldwide. Few studies have previously investigated the genetic susceptibility and potential risk factors for LRTI. ...
    • Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease 

      Zheng, Jie; Zhang, Yuemiao; Rasheed, Humaira; Walker, Venexia M.; Sugawara, Yuka; Li, Jiachen; Leng, Yue; Elsworth, Benjamin; Wootton, Robyn E.; Fang, Si; Yang, Qian; Burgess, Stephen; Haycock, Philip C.; Borges, Maria Carolina; Carnegie, Rebecca; Cho, Yoonsu; Howell, Amy; Robinson, Jamie; Thomas, Laurent; Brumpton, Ben Michael; Hveem, Kristian; Hallan, Stein; Franceschini, Nora; Morris, Andrew P.; Köttgen, Anna; Pattaro, Cristian; Wuttke, Matthias; Yamamoto, Masayuki; Kashihara, Naoki; Akiyama, Masato; Kanai, Masahiro; Matsuda, Koichi; Kamatani, Yoichiro; Okada, Yukinori; Walters, Robin; Millwood, Iona Y.; Chen, Zhengming; Smith, George Davey; Barbour, Sean; Yu, Canqing; Åsvold, Bjørn Olav; Zhang, Hong; Gaunt, Tom R. (Peer reviewed; Journal article, 2021)
      Background: This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD in European and East Asian ancestries using Mendelian randomization. ...
    • Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition 

      Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad; Laugsand, Lars Erik; Aukrust, Pål; Vatten, Lars Johan; Damås, Jan Kristian; Ueland, Thor; Janszky, Imre; Zwart, John-Anker; van't Hooft, Ferdinand M.; Seidah, Nabil Georges; Hveem, Kristian; Willer, Cristen; Smith, George Davey; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2019)
      PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce serum LDL (low-density lipoprotein) cholesterol (LDL-C) by increasing uptake in the liver. Although some long-term trials have evaluated their safety, ...