Blar i NTNU Open på forfatter "Pillai, Ramesh S."
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Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility
Dohnalkova, Michaela; Krasnykov, Kyrylo; Mendel, Mateusz; Li, Lingyun; Panasenko, Olesya; Fleury-Olela, Fabienne; Vågbø, Cathrine Broberg; Homolka, David; Pillai, Ramesh S. (Peer reviewed; Journal article, 2023)Eukaryotic RNA pol II transcripts are capped at the 5′ end by the methylated guanosine (m7G) moiety. In higher eukaryotes, CMTR1 and CMTR2 catalyze cap-proximal ribose methylations on the first (cap1) and second (cap2) ... -
The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues
Pandey, Radha Raman; Delfino, Elena; Homolka, David; Roithova, Adriana; Chen, Kuan-Ming; Li, Lingyun; Franco, Giulia; Vågbø, Cathrine Broberg; Taillebourg, Emmanuel; Fauvarque, Marie-Odile; Pillai, Ramesh S. (Peer reviewed; Journal article, 2020)The 5′ end of eukaryotic mRNAs is protected by the m7G-cap structure. The transcription start site nucleotide is ribose methylated (Nm) in many eukaryotes, whereas an adenosine at this position is further methylated at the ... -
Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing
Mendel, Mateusz; Delaney, Kamila; Pandey, Radha Raman; Chen, Kuan-Ming; Wenda, Joanna M.; Vågbø, Cathrine Broberg; Steiner, Florian A.; Homolka, David; Pillai, Ramesh S. (Journal article; Peer reviewed, 2021)The N6-methyladenosine (m6A) RNA modification is used widely to alter the fate of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse METTL16) deposits an m6A mark on the 3′ splice site ...