• Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits 

      Nayor, Matthew; Short, Meghan I.; Rasheed, Humaira; Lin, Honghuang; Jonasson, Christian; Yang, Qiong; Hveem, Kristian; Felix, Janine F.; Morrison, Alanna C.; Wild, Philipp S.; Morley, Michael P.; Cappola, Thomas P.; Benson, Mark D.; Ngo, Debby; Sinha, Sumita; Keyes, Michelle J.; Shen, Dongxiao; Wang, Thomas J.; Larson, Martin G.; Brumpton, Ben Michael; Gerszten, Robert E.; Omland, Torbjørn; Vasan, Ramachandran S. (Peer reviewed; Journal article, 2020)
      Abstract Background: We used a large-scale, high-throughput DNA aptamer-based discovery proteomic platform to identify circulating biomarkers of cardiac remodeling and incident heart failure (HF) in community-dwelling ...
    • Cardiac pathology 6 months after hospitalization for COVID-19 and association with the acute disease severity 

      Myhre, Peder Langeland; Heck, Siri Lagethon; Skranes, Julia Brox; Prebensen, Christian Haugland; Jonassen, Christine M; Berge, Trygve; Mecinaj, Albulena; Einvik, Gunnar; Melles, Woldegabriel A; Ingul, Charlotte Bjørk; Tveit, Arnljot; Berdal, Jan-Erik; Røsjø, Helge Rørvik; Lyngbakken, Magnus Nakrem; Omland, Torbjørn (Peer reviewed; Journal article, 2021)
      Background Coronavirus disease 2019 (COVID-19) may cause myocardial injury and myocarditis, and reports of persistent cardiac pathology after COVID-19 have raised concerns of long-term cardiac consequences. We aimed to ...
    • Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 Study 

      Rutkovskiy, Arkady; Lyngbakken, Magnus; Dahl, Mai Britt; Bye, Anja; Pedersen, Marit Holmefjord; Wisløff, Ulrik; Christensen, Geir Arve; Høiseth, Arne Didrik; Omland, Torbjørn; Røsjø, Helge (Peer reviewed; Journal article, 2021)
      Background MicroRNA (miR)-210 expression is induced by acute and chronic hypoxia and provides prognostic information in patients with aortic stenosis and acute coronary syndrome. We hypothesized that circulating miR-210 ...
    • Circulating MicroRNAs and Aerobic Fitness - The HUNT-Study 

      Bye, Anja; Røsjø, Helge; Aspenes, Stian Thoresen; Condorelli, Gianluigi; Omland, Torbjørn; Wisløff, Ulrik (Journal article; Peer reviewed, 2013)
      Aerobic fitness, measured as maximal oxygen uptake (VO2max), is a good indicator of cardiovascular health, and a strong predictor of cardiovascular mortality. Biomarkers associated with low VO2max may therefore represent ...
    • Circulating microRNAs as predictive biomarkers of myocardial infarction: Evidence from the HUNT study. 

      Velle-Forbord, Torbjørn; Eidlaug, Maria; Debik, Julia Barbara; Sæther, Julie Caroline; Follestad, Turid; Nauman, Javaid; Gigante, Bruna; Røsjø, Helge; Omland, Torbjørn; Langaas, Mette; Bye, Anja (Peer reviewed; Journal article, 2019)
      Background and aims Several risk prediction models for coronary heart disease (CHD) are available today, however, they only explain a modest proportion of the incidence. Circulating microRNAs (miRs) have recently been ...
    • Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction 

      Koppen, Elias; Omland, Torbjørn; Larsen, Alf Inge; Karlsen, Trine; Linke, Axel; Prescott, Eva Irene Bossano; Halle, Martin; Dalen, Håvard; Delagardelle, Charles; Hole, Torstein; van Craenenbroeck, Emeline M.; Beckers, Paul; Ellingsen, Øyvind; Feiereisen, Patrick; Valborgland, Torstein; Videm, Vibeke (Journal article; Peer reviewed, 2021)
      Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect ...
    • Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction 

      Koppen, Elias; Omland, Torbjørn; Larsen, Alf Inge; Karlsen, Trine; Linke, Axel; Prescott, Eva Irene Bossano; Halle, Martin; Dalen, Håvard; Delagardelle, Charles; Hole, Torstein; van Craenenbroeck, Emeline M.; Beckers, Paul; Ellingsen, Øyvind; Feiereisen, Patrick; Valborgland, Torstein; Videm, Vibeke (Peer reviewed; Journal article, 2021)
      Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect ...
    • Genome-wide association study of cardiac troponin i in the general population 

      Moksnes, Marta Riise; Røsjø, Helge; Richmond, Anne; Lyngbakken, Magnus N; Graham, Sarah E; Wolford, Brooke N; Hansen, Ailin Falkmo; Gagliano Taliun, Sarah A; Lefaive, Jonathon; Rasheed, Humaira; Thomas, Laurent; Zhou, Wei; Aung, Nay; Surakka, Ida; Douville, Nicholas J; Campbell, Archie; Porteous, David J; Petersen, Steffen E; Munroe, Patricia B; Welsh, Paul; Sattar, Naveed; Smith, George Davey; Fritsche, Lars G; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Hveem, Kristian; Hayward, Caroline; Willer, Cristen J; Brumpton, Ben M; Omland, Torbjørn (Peer reviewed; Journal article, 2021)
      Circulating cardiac troponin proteins are associated with structural heart disease and predict incident cardiovascular disease in the general population. However, the genetic contribution to cardiac troponin I (cTnI) ...
    • Insomnia symptoms and subclinical myocardial injury: Data from the Nord-Trøndelag Health (HUNT) study 

      Sigurdardottir, Fjola Dogg; Sigurdardóttir, Fjóla Dögg; Lyngbakken, Magnus; Hveem, Kristian; Hrubos-Strøm, Harald; Røsjø, Helge; Redline, Susan; Omland, Torbjørn (Peer reviewed; Journal article, 2021)
      Insomnia symptoms are associated with increased risk of heart failure (HF) and cardiovascular (CV) mortality. We hypothesised that insomnia symptoms are cross-sectionally associated with increased cardiac troponin I (cTnI), ...
    • Lifetime obesity trends are associated with subclinical myocardial injury: The Trøndelag health study 

      Lyngbakken, Magnus Nakrem; De Lemos, James A.; Hveem, Kristian; Røsjø, Helge Rørvik; Omland, Torbjørn (Journal article; Peer reviewed, 2021)
      Background Obesity is associated with subclinical myocardial injury as quantified by concentrations of cardiac troponin T, but whether lifetime excess weight history is associated with increased concentrations of cardiac ...
    • Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis 

      Røsjø, Helge; Dahl, Mai Britt; Bye, Anja; Andreassen, Johanna; Jørgensen, Marit; Wisløff, Ulrik; Christensen, Geir Arve; Edvardsen, Thor; Omland, Torbjørn (Journal article; Peer reviewed, 2014)
      Background: Circulating micro-RNAs have been proposed as a novel class of cardiovascular (CV) biomarkers, but whether they meet analytical requirements and provide additional information to establish risk indices have ...
    • Rationale and design of the PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial: a randomized, placebo-controlled, multicenter trial 

      Mecinaj, Albulena; Gulati, Geeta; Heck, Siri Lagethon; Holte, Espen; Fagerland, Morten Wang; Larsen, Alf Inge; Blix, Egil Støre; Geisler, Jürgen; Wethal, Torgeir; Omland, Torbjørn (Journal article, 2021)
      Background Recent advances in the treatment algorithms of early breast cancer have markedly improved overall survival. However, anthracycline- and trastuzumab-associated cardiotoxicity may lead to dose-reduction or halt ...
    • Relative prognostic value of cardiac troponin I and C-reactive protein in the general population (from the Nord-Trøndelag Health [HUNT] Study) 

      Sigurdardottir, Fjola Dogg; Lyngbakken, Magnus Nakrem; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian; Røsjø, Helge; Omland, Torbjørn (Journal article; Peer reviewed, 2018)
      C-reactive protein and cardiac troponin I measured with high-sensitivity assays (high-sensitivity C-reactive protein [hs-CRP] and high-sensitivity troponin I [hs-TnI]) have been associated with risk of fatal and nonfatal ...
    • SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe 

      Achenbach, Stephan; Aleksandrova, Krasimira; Amiano, Pilar; Amouyel, Philippe; Andersson, Jonas; Bakker, Stephan J.L.; Meyer, Haakon Eduard; Selmer, Randi Marie; Braaten, Tonje; Hveem, Kristian; Lyngbakken, Magnus Nakrem; Mathiesen, Ellisiv B.; Omland, Torbjørn; Wilsgaard, Tom; Costa, Rui Bebiano Da Providencia; Beulens, Joline W. J.; Blaha, Michael J.; Bobak, Martin; Boer, Jolanda M.A.; Bonet, Catalina; Bonnet, Fabrice; Boutron-Ruault, Marie-Christine; Brenner, Hermann; Brunner, Fabian; Brunner, Eric J.; Brunström, Mattias; Buring, Julie; Butterworth, Adam S.; Capkova, Nadezda; Cesana, Giancarlo; Chrysohoou, Christina; Colorado-Yohar, Sandra; Cook, Nancy R.; Cooper, Cyrus; Dahm, Christina C.; Davidson, Karina W.; Dennison, Elaine; Castelnuovo, Augusto Di; Donfrancesco, Chiara; Dörr, Marcus; Dorynska, Agnieszka; Eliasson, Mats; Engström, Gunnar; Ferrari, Pietro; Ferrario, Marco; Ford, Ian; Fu, Michael; Gansevoort, Ron T.; Giampaoli, Simona; Gillum, Richard F. (Peer reviewed; Journal article, 2021)
      Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or ...
    • Subclinical myocardial injury and risk of COVID-19 in the general population: The Trøndelag Health Study 

      Lyngbakken, Magnus Nakrem; Hveem, Kristian; Røsjø, Helge Rørvik; Omland, Torbjørn (Peer reviewed; Journal article, 2021)
    • Temporal changes in cardiac troponin i are associated with risk of cardiovascular events in the general population: The Nord-Trøndelag health study 

      Lyngbakken, Magnus; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian; Omland, Torbjørn (Journal article; Peer reviewed, 2019)
      BACKGROUND:Cardiac troponins are associated with car-diovascular risk in the general population, but whethertemporal changes in cardiac troponin I provide indepen-dent prognostic information remains uncertain. Using alarge ...