Browsing NTNU Open by Author "Oksenych, Valentyn"
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Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study
Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lysvand, Hilde; Oksenych, Valentyn; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2021)Background: Every year, millions of people are hospitalized and thousands die from influenza A virus (FLUAV) infection. Most cases of hospitalizations and death occur among the elderly. Many of these elderly patients are ... -
Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins
Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik; Kakkola, Laura; Nandania, Jatin; Turunen, Laura; Ohman, Tiina; Ala-Hongisto, Hanna; Pesonen, Hanna M; Kuisma, Marika S; Honkimaa, Anni; Walton, Emma Louise; Oksenych, Valentyn; Lorey, Martina B.; Guschin, Dmitry; Shim, Jungmin; Kim, Jinhee; Than, Thoa T; Chang, So Young; Hukkanen, Veijo; Kulesskiy, Evgeny; Marjomaki, Varpu S; Julkunen, Ilkka; Nyman, Tuula Anneli; Matikainen, Sampsa; Saarela, Jani S; Sane, Famara; Hober, Didier; Gabriel, Gulsah; De Brabander, Jef K; Martikainen, Miika; Windisch, Marc P; Min, Ji-Young; Bruzzone, Roberto; Aittokallio, Tero; Vaha-Koskela, Markus; Vapalahti, Olli; Pulk, Arto; Velagapudi, Vidya; Kainov, Denis (Journal article; Peer reviewed, 2017)Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, ... -
Bioisosteric Replacement in the Search for Biologically Active Compounds: Design, Synthesis and Anti-Inflammatory Activity of Novel [1,2,4]triazino[2,3-c]quinazolines
Grytsak, Oleksandr; Shabelnyk, Kostiantyn; Severina, Hanna; Ryzhenko, Victor; Voskoboinik, Oleksii; Belenichev, Igor; Kovalenko, Serhii; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024)Background: Designing novel biologically active compounds with anti-inflammatory properties based on condensed quinazolines is a significant area of interest in modern medicinal chemistry. In the present study, we describe ... -
Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study.
Fenstad, Mona H.; Ravlo, Erlend; Ianevski, Aleksandr; Starheim, Eirin Johannessen; Wang, Wei; Lysvand, Hilde; Smura, Teemu; Ji, Ping; Kivi, Gaily; Voolaid, Maia-Liisa; Plaan, Kati; Ustav, Mart; Ustav, Mart; Žusinaite, Eva; Tenson, Tanel; Kurg, Reet; Oksenych, Valentyn; Walstad, Kirsti; Nordbø, Svein Arne; Kaarbø, Mari; Ernits, Karin; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2023)Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how messenger RNA (mRNA) vaccination of convalescents provides protection from emerging virus variants. ... -
Characterization of a Paxx Knockout Mouse Model - Growth and immune system development in mice deficient of DNA repair factor PAXX
Sæterstad, Siri (Master thesis, 2018)Non-Homologous End-Joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in higher eukaryotes, functional throughout the cell cycle. NHEJ involves a variety of proteins; some are essential, whereas others ... -
Characterization of new mouse model lacking DNA repair factor MRI
Røsand, Øystein (Master thesis, 2019)Double-strand breaks (DSBs) are constantly generated in the DNA by endogenous and exogenous agents. In mammalian cells, DSBs activate DNA damage responses (DDRs) to repair the lesions. One major DSB repair pathway is ... -
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis
Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Evandro Fei; Kainov, Denis (Journal article; Peer reviewed, 2020)Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ... -
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants
Ianevski, Aleksandr; Frøysa, Irene Trøen; Lysvand, Hilde; Calitz, Carlemi; Smura, Teemu; Nilsen, Hans-Johnny; Høyer, Erling; Afset, Jan Egil; Sridhar, Adithya; Wolthers, Katja C.; Zusinaite, Eva; Tenson, Tanel; Kurg, Reet; Oksenych, Valentyn; Galabov, Angel S.; Stoyanova, Adelina; Bjørås, Magnar; Kaynov, Denis (Peer reviewed; Journal article, 2024)Enteroviruses are a significant global health concern, causing a spectrum of diseases from the common cold to more severe conditions like hand-foot-and-mouth disease, meningitis, myocarditis, pancreatitis, and poliomyelitis. ... -
Common nodes of virus–host interaction revealed through an integrated network analysis
Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ... -
Discovery and development of safe-in-man broad-spectrum antiviral agents
Anderssen, Petter Inge; Ianevski, Aleksandr; Lysvand, Hilde; Vitkauskiene, Astra; Oksenych, Valentyn; Bjørås, Magnar; Telling, Kaidi; Lutsar, Irja; Dumpis, Uga; Irie, Yasuhiko; Tenson, Tanel; Kantele, Anu; Kainov, Denis (Peer reviewed; Journal article, 2020)Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral ... -
DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)
Ianevski, Aleksandr; Simonsen, Ronja Meyer; Myhre, Vegard; Tenson, Tanel; Oksenych, Valentyn; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)Viruses can cross species barriers and cause unpredictable outbreaks in man with substantial economic and public health burdens. Broad-spectrum antivirals, (BSAs, compounds inhibiting several human viruses), and BSA-containing ... -
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren
Castaneda Zegarra, Sergio Miguel; Huse, Camilla; Røsand, Øystein; Sarno, Antonio; Xing, Mengtan; Zhang, Qindong; Alirezaylavasani, Amin; Werner, Julia; Ji, Ping; Liabakk, Nina-Beate; Wang, Wei; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes, and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological ... -
Genetic Interaction Between DNA Repair Factors in Lymphocyte Development
Huse, Camilla (Master thesis, 2019)Dobbeltråd-brudd (DSB) på DNA-tråden er den mest cytotoksiske skaden i cellene våre. I løpet av utviklingen av B- og T-celler introduseres DSBs med vilje i løpet av V(D)J rekombinasjonen, og repareres av den ikke-homologe ... -
Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells
Xing, Mengtan; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)DNA double‐strand breaks (DSBs) are highly cytotoxic lesions, and unrepaired or misrepaired DSBs can lead to various human diseases, including immunodeficiency, neurological abnormalities, growth retardation, and cancer. ... -
Genetic interaction between the non-homologous end joining factors in mice and humans
Xing, Mengtan (Doctoral theses at NTNU;2019:117, Doctoral thesis, 2019) -
Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models
Castaneda Zegarra, Sergio Miguel; Fernandez Berrocal, Marion Silvana; Tkachev, Max; Yao, Rouan; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)Non-homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double-strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J ... -
Identification and Tracking of Antiviral Drug Combinations
Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart Jr; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskienė, Astra; Windisch, Marc P; Fenstad, Mona H.; Nordbø, Svein Arne; Ustav, Mart; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2020)Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ... -
Immunoregulatory Intestinal Microbiota and COVID-19 in Patients with Type Two Diabetes: A Double-Edged Sword
Petakh, Pavlo; Kamyshna, Iryna; Nykyforuk, Andriy; Yao, Rouan; Imbery, John Franklin; Oksenych, Valentyn; Korda, Mykhaylo; Kamyshnyi, Aleksandr (Peer reviewed; Journal article, 2022)Coronavirus disease 2019, or COVID-19, is a major challenge facing scientists worldwide. Alongside the lungs, the system of organs comprising the GI tract is commonly targeted by COVID-19. The dysbiotic modulations in the ... -
Impact of DNA double-strand break response factors on B and T lymphocyte development
Castañeda-Zegarra, Sergio Miguel (Doctoral theses at NTNU;2022:224, Doctoral thesis, 2022)Sammendrag på norsk Virkningen av DNA-dobbeltrådbrudd responsfaktorer på B- og T-lymfocytt utvikling De mest cytotoksiske DNA-skadene i en celle er forårsaket av brudd på dobbelttrådet DNA (DSB). NHEJ er en essensiell ... -
Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation
Ragunathan, Kalaiyarasi; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)Cancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess immunomodulatory functions by interacting with other cells surrounding tumor, including T lymphocytes, macrophages, dendritic cells ...