• Robust DNA repair in PAXX-deficient mammalian cells 

      Dewan, Alisa Elinsdatter; Xing, Mengtan; Lundbæk, Marie Benner; Gago-Fuentes, Raquel; Beck, Carole; Aas, Per Arne; Liabakk, Nina-Beate; Sæterstad, Siri; Khac Thanh Phong, Chau; Kavli, Bodil Merete; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)
      To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ...
    • Role of GCN5 and PCAF in the B Lymphocyte Development 

      Chau, Khac Thanh Phong (Master thesis, 2018)
      DNA in our cells is constantly damage by internal and external factors generating DSBs. To maintain genome stability, cells have developed various DNA damage surveillance and repair mechanisms to prevent chromosomal ...
    • Role of GCN5 and PCAF in the B Lymphocyte Development 

      Chau, Khac Thanh Phong (Master thesis, 2018)
      DNA in our cells is constantly damage by internal and external factors generating DSBs. To maintain genome stability, cells have developed various DNA damage surveillance and repair mechanisms to prevent chromosomal ...
    • Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections 

      Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji; Yang, Jaewon; Ravlo, Erlend; Wang, Wei; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Tenson, Tanel; Windisch, Marc P.; Poranen, Minna M.; Nieminen, Anni I.; Nordbø, Svein Arne; Fenstad, Mona H.; Grødeland, Gunnveig; Aukrust, Pål; Trøseid, Marius; Kantele, Anu; Lastauskienė, Eglė; Vitkauskienė, Astra; Legrand, Nicolas; Merits, Andres; Bjørås, Magnar; Kainov, Denis (Journal article; Peer reviewed, 2021)
      Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in ...
    • Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53 

      Castañeda-Zegarra, Sergio; Xing, Mengtan; Gago-Fuentes, Raquel; Sæterstad, Siri; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)
      Non-homologous end joining (NHEJ) is a DNA repair pathway that senses, processes and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. During NHEJ, core Ku70 and Ku80 subunits bind DSBs as a heterodimer ...
    • Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70 

      Xing, Mengtan; Bjørås, Magnar; Daniel, Jeremy A.; Alt, Frederick W.; Oksenych, Valentyn (Journal article; Peer reviewed, 2017)
      DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds ...